公开(公告)号：US09079890B2

公开(公告)日：2015-07-14

申请号：US14494430

申请日：2014-09-23

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

IPC: C07D417/00 ,  C07D401/14 ,  C07D417/14 ,  C07D213/75 ,  C07D417/12 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are intermediates having the formulas wherein R2, R3, and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

Abstract translation: 提供具有下式的中间体其中R2，R3和L如说明书中所定义，其可用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物。

公开(公告)号：US20140256756A1

公开(公告)日：2014-09-11

申请号：US14355804

申请日：2012-10-30

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Josef Roland Benscik ,  Steven Armen Boyd ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John Peter Fischer ,  Ronald Jay Hinklin ,  Scott Pratt ,  Ajay Singh ,  Timothy M. Turner

IPC: C07D417/14 ,  C07D413/14

CPC classification number: C07D417/14 ,  C07D413/14

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, X3, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，X3，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防 的疾病，例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

公开(公告)号：US20150057448A1

公开(公告)日：2015-02-26

申请号：US14494430

申请日：2014-09-23

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

IPC: C07D401/14 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are intermediates having the formulas wherein R2, R3, and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

Abstract translation: 提供具有下式的中间体其中R2，R3和L如说明书中所定义，其可用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物。

公开(公告)号：US08883828B2

公开(公告)日：2014-11-11

申请号：US13669083

申请日：2012-11-05

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Ronald Jay Hinklin ,  Ajay Singh

IPC: A01N43/40 ,  C07D417/00 ,  C07D417/14 ,  C07D491/04 ,  C07D487/04 ,  C07D513/04 ,  C07D417/12 ,  C07D471/04 ,  C07D413/14 ,  C07D495/04

CPC classification number: C07D417/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

Abstract translation: 提供了可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病的化合物。 还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。