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公开(公告)号：US11058762B2
公开(公告)日：2021-07-13
申请号：US14130869
申请日：2012-07-06
Applicant: Andrew Geall , Gillis Otten , Susan Barnett
Inventor： Andrew Geall , Gillis Otten , Susan Barnett
IPC: A61K39/155 , A61K39/245 , A61K39/12 , A61P31/20 , A61P31/14 , A61K39/00
Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions.
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公开(公告)号：US20140242152A1
公开(公告)日：2014-08-28
申请号：US14130869
申请日：2012-07-06
Applicant: Andrew Geall , Gillis Otten , Susan Barnett
Inventor： Andrew Geall , Gillis Otten , Susan Barnett
IPC: A61K39/155 , A61K39/245
CPC classification number: A61K39/155 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55588 , A61P31/14 , A61P31/20 , C12N2710/16134 , C12N2760/18534 , C12N2770/36143
Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions.
Abstract translation: 本发明一般涉及包含RNA组分和多肽组分的免疫原性组合物。 以两种不同形式递送抗原表位的免疫原性组合物 - 来自病原体的第一个表位，以RNA编码的形式; 和来自相同病原体的多肽形式的第二表位有效诱导对病原体的免疫应答。 本发明还涉及包含基于RNA的引发组合物和基于多肽的增强组合物的试剂盒。 该试剂盒可以用于顺序施用引发剂和促进组合物。
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3.发明授权Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 失效使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US08647864B2
公开(公告)日：2014-02-11
申请号：US12825722
申请日：2010-06-29
Applicant: John M Polo , Thomas W Dubensky, Jr. , Ilya Frolov , Jason P Gardner , Gillis Otten , Susan Barnett , David A Driver
Inventor： John M Polo , Thomas W Dubensky, Jr. , Ilya Frolov , Jason P Gardner , Gillis Otten , Susan Barnett , David A Driver
CPC classification number: A61K39/12 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2740/16134 , C12N2740/16234 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36145 , C12N2810/609
Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
Abstract translation: 提供了用于真核分层载体启动系统和甲病毒复制子颗粒的组合物和方法，用于将异源序列引入细胞以产生免疫应答。
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4.发明申请Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems 失效用于产生使用基于甲病毒的载体系统的免疫应答的组合物和方法公开(公告)号：US20100266631A1
公开(公告)日：2010-10-21
申请号：US12825722
申请日：2010-06-29
Applicant: John Polo , Thomas W. Dubensky, JR. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
Inventor： John Polo , Thomas W. Dubensky, JR. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC classification number: A61K39/12 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2740/16134 , C12N2740/16234 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36145 , C12N2810/609
Abstract: Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
Abstract translation: 提供了用于真核分层载体启动系统和甲病毒复制子颗粒的组合物和方法，用于将异源序列引入细胞以产生免疫应答。
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5.发明申请Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 有权使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US20080226598A1
公开(公告)日：2008-09-18
申请号：US11712044
申请日：2007-02-27
Applicant: John Polo , Thomas W. Dubensky , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
Inventor： John Polo , Thomas W. Dubensky , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC classification number: C07K14/005 , A61K35/00 , A61K2039/5256 , C12N15/86 , C12N2740/16122 , C12N2770/36143
Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
Abstract translation: 提供了使用基于甲病毒的载体系统产生免疫应答的方法。
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Patent Agency Ranking
6.发明授权Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 有权使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US07771979B2
公开(公告)日：2010-08-10
申请号：US11712044
申请日：2007-02-27
Applicant: John Polo , Thomas W. Dubensky, Jr. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
Inventor： John Polo , Thomas W. Dubensky, Jr. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC classification number: C07K14/005 , A61K35/00 , A61K2039/5256 , C12N15/86 , C12N2740/16122 , C12N2770/36143
Abstract: Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
Abstract translation: 提供了使用基于甲病毒的载体系统产生免疫应答的方法。
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公开(公告)号：US20080026071A1
公开(公告)日：2008-01-31
申请号：US11653792
申请日：2007-01-16
Applicant: Derek O'Hagan , Gillis Otten , John Donnelly , John Polo , Susan Barnett , Manmohan Singh , Jeffrey Ulmer , Thomas Dubensky
Inventor： Derek O'Hagan , Gillis Otten , John Donnelly , John Polo , Susan Barnett , Manmohan Singh , Jeffrey Ulmer , Thomas Dubensky
IPC: A61K39/21 , A61K39/00 , A61K39/12 , A61K39/125 , A61K39/29 , A61P31/04 , A61P33/00 , A61P31/12 , A61K9/50 , A61K39/215 , A61K39/145 , A61K39/155
CPC classification number: C12N15/86 , A61K9/1647 , A61K9/167 , A61K39/00 , A61K39/12 , A61K39/21 , A61K47/6927 , A61K2039/53 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16134 , C12N2740/16234 , C12N2770/36143 , Y02A50/388
Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. Also provided are microparticles in the form of submicron emulsions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. The surface of the microparticles efficiently adsorb polypeptides, such as antigens, and nucleic acids, such as ELVIS vectors and other vector constructs, containing heterologous nucleotide sequences encoding biologically active macromolecules, such as polypeptides, antigens, and adjuvants. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and uses of the microparticle compositions for vaccines are also provided.
Abstract translation: 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 还提供了具有可代谢油和乳化剂的油滴乳液的亚微米乳液形式的微粒。 微粒的表面有效地吸收多肽，如抗原和核酸，如ELVIS载体和其他载体构建体，其含有编码生物活性大分子如多肽，抗原和佐剂的异源核苷酸序列。 还提供了刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及微粒组合物用于疫苗的用途。
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8.发明授权Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2 有权表达盒在V1和V2中以缺失形式编码HIV-1南非亚型C修饰的ENV蛋白公开(公告)号：US08133494B2
公开(公告)日：2012-03-13
申请号：US11724050
申请日：2007-03-13
Applicant: Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
Inventor： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse van Rensburg , Thomas J. Scriba
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2720/00034 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2799/027 , C12N2800/108 , C12N2830/42 , C12N2840/203
Abstract: The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.
Abstract translation: 本发明涉及编码经修饰的免疫原性HIV-1南非亚型C Env多肽的多核苷酸。 对Env多肽的修饰包括缺失V1，V2和茎区。 表达盒可以用于例如表达编码的多肽。 还描述了用于选择的宿主细胞中的重组表达系统，其包含编码经修饰的HIV-1 Env多肽的表达盒。
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公开(公告)号：US20050287167A1
公开(公告)日：2005-12-29
申请号：US11124602
申请日：2005-05-05
Applicant: Jan zur Megede , Susan Barnett
Inventor： Jan zur Megede , Susan Barnett
CPC classification number: C07K14/005 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/36143
Abstract: The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions comprising these vectors and sequences along with methods of using these vectors and sequences are also disclosed.
Abstract translation: 本公开涉及包含编码HIV多肽的多核苷酸序列的载体。 具体地，本公开涉及包含将HIV多肽编码为单一多蛋白的序列的多顺反子载体构建体。 还公开了包含这些载体和序列的组合以及使用这些载体和序列的方法。
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10.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE C POLYPEPTIDES, POLYPEPTIDES AND USES THEREOF 审中-公开多核苷酸编码抗原型HIV多肽，多肽及其用途公开(公告)号：US20100316698A1
公开(公告)日：2010-12-16
申请号：US12620511
申请日：2009-11-17
Applicant: Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse Van Rensburg
Inventor： Jan zur Megede , Susan Barnett , Ying Lian , Susan Engelbrecht , Estrelita Janse Van Rensburg
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
Abstract: The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.
Abstract translation: 本发明涉及编码免疫原性HIV C型多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，包装细胞系的产生和HIV C型蛋白的产生的应用中的用途。
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