公开(公告)号：US20180112192A1

公开(公告)日：2018-04-26

申请号：US15571249

申请日：2016-05-02

Applicant: Andrew Man Chung Wo ,  National Taiwan University ,  Academia Sinica

Inventor： Pan-Chyr Yang ,  Pei-Ying Lin ,  Bo-Tsang Huang

IPC: C12N9/12 ,  A61P35/00 ,  A61K38/45 ,  A61K45/06

CPC classification number: C12N9/12 ,  A61K31/517 ,  A61K31/5377 ,  A61K38/179 ,  A61K38/45 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K14/00 ,  C07K14/71 ,  C07K2319/10 ,  C07K2319/41 ,  C07K2319/43 ,  C12Y207/11001 ,  A61K2300/00

Abstract: The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.

公开(公告)号：US20170211067A1

公开(公告)日：2017-07-27

申请号：US15500345

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University ,  Taipei Medical University

Inventor： Konan Peck ,  Pan-Chyr Yang ,  Yi-Chung Chang ,  Bo-Tsang Huang ,  Shauh-Der Yeh

IPC: C12N15/115 ,  A61K9/00 ,  A61K31/713

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

公开(公告)号：US11214774B2

公开(公告)日：2022-01-04

申请号：US15571249

申请日：2016-05-02

Applicant: Andrew Man Chung Wo ,  National Taiwan University ,  Academia Sinica

Inventor： Pan-Chyr Yang ,  Pei-Ying Lin ,  Bo-Tsang Huang

IPC: C07K5/00 ,  C12N9/12 ,  A61K45/06 ,  C07K14/00 ,  A61K39/395 ,  C07K14/71 ,  A61K31/517 ,  A61K38/17 ,  A61K31/5377 ,  A61P35/00 ,  A61K38/45

Abstract: The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.

公开(公告)号：US10584341B2

公开(公告)日：2020-03-10

申请号：US15755958

申请日：2016-08-31

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Wei-Yun Lai ,  Bo-Tsang Huang

IPC: C12N15/11 ,  C12N15/115 ,  A61K31/711 ,  A61P35/00

Abstract: Aptamers that bind to and antagonize PDL1 and uses thereof in enhancing immune activity (e.g., promoting T cell proliferation), treating cancer, and/or infectious diseases such as infections caused by enterovirus, HBV, or HCV infection.

公开(公告)号：US10533179B2

公开(公告)日：2020-01-14

申请号：US15500345

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University ,  Taipei Medical University

Inventor： Konan Peck ,  Pan-Chyr Yang ,  Yi-Chung Chang ,  Bo-Tsang Huang ,  Shauh-Der Yeh

IPC: C12N15/115 ,  C12N15/113 ,  A61K31/711 ,  A61K9/00 ,  A61K31/713 ,  A61K47/60

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

公开(公告)号：US20180258431A1

公开(公告)日：2018-09-13

申请号：US15755958

申请日：2016-08-31

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Wei-Yun Lai ,  Bo-Tsang Huang

IPC: C12N15/115 ,  A61P35/00

CPC classification number: C12N15/115 ,  A61K31/711 ,  A61P35/00 ,  C12N2310/16 ,  Y02A50/463

Abstract: Aptamers that bind to and antagonize PDL1 and uses thereof in enhancing immune activity (e.g., promoting T cell proliferation), treating cancer, and/or infectious diseases such as infections caused by enterovirus, HBV, or HCV infection.