ANTAGONISTIC CTLA-4 APTAMERS AND APPLICATIONS THEREOF IN ENHANCING IMMUNE ACTIVITY

Invention Application

US20170211067A1 ANTAGONISTIC CTLA-4 APTAMERS AND APPLICATIONS THEREOF IN ENHANCING IMMUNE ACTIVITY 审中-公开

Patent Title: ANTAGONISTIC CTLA-4 APTAMERS AND APPLICATIONS THEREOF IN ENHANCING IMMUNE ACTIVITY
Application No.: US15500345

Application Date: 2015-07-31
Publication No.: US20170211067A1

Publication Date: 2017-07-27
Inventor: Konan Peck , Pan-Chyr Yang , Yi-Chung Chang , Bo-Tsang Huang , Shauh-Der Yeh
Applicant: Academia Sinica , National Taiwan University , Taipei Medical University
Applicant Address: TW Taipei TW Taipei TW Taipei City
Assignee: Academia Sinica,National Taiwan University,Taipei Medical University
Current Assignee: Academia Sinica,National Taiwan University,Taipei Medical University
Current Assignee Address: TW Taipei TW Taipei TW Taipei City
International Application: PCT/US2015/043133 WO 20150731
Main IPC: C12N15/115
IPC: C12N15/115 ; A61K9/00 ; A61K31/713

Abstract:

Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

Public/Granted literature

Information query

Global Dossier Espacenet

IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N15/00	突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主（突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00；新的植物入A01H；用组织培养技术再生植物入A01H4/00；新的动物入A01K67/00；含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用，基因疗法入A61K48/00，一般肽入C07K）
C12N15/09	.DNA重组技术
C12N15/11	..DNA或RNA片段；其修饰形成（不用于重组技术的DNA或RNA入C07H21/00）
C12N15/115	...适体（aptamers），即与靶分子特异性、高亲和力结合，但不与其杂交的核酸