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公开(公告)号：US12006352B2
公开(公告)日：2024-06-11
申请号：US16823412
申请日：2020-03-19
Applicant: Ablynx N.V. , Sanofi
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC: C07K16/00 , C07K16/18 , A61K39/00 , A61K39/395 , C07K16/28 , C07K16/42 , G01N33/53 , G01N33/543 , G01N33/68
CPC classification number: C07K16/00 , C07K16/18 , A61K39/39533 , A61K2039/505 , C07K16/28 , C07K16/2875 , C07K16/42 , C07K16/4283 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5306 , G01N33/54393 , G01N33/6854 , G01N33/6857
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal;—methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal;—modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US20220213215A1
公开(公告)日：2022-07-07
申请号：US17553908
申请日：2021-12-17
Applicant: Ablynx N.V. , Sanofi
Inventor： Daniel Janssen , Carlo Boutton , Evelyne Dombrecht , Bram Laukens , Paolo Meoni , Lily Pao , Jan Pype , Peter Schotte , Benedikte Serruys , Ana Paula Vintem , Diane Van Hoorick
Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.
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3.发明公开公开(公告)号：US20240343823A1
公开(公告)日：2024-10-17
申请号：US18432750
申请日：2024-02-05
Applicant: Ablynx N.V. , Sanofi
Inventor： Daniel Janssen , Carlo Boutton , Evelyne Dombrecht , Bram Laukens , Paolo Meoni , Lily Pao , Jan Pype , Peter Schotte , Benedikte Serruys , Ana Paula Vintem , Diane Van Hoorick
CPC classification number: C07K16/303 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92 , C07K2319/30
Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.
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公开(公告)号：US11932702B2
公开(公告)日：2024-03-19
申请号：US17553908
申请日：2021-12-17
Applicant: Ablynx N.V. , Sanofi
Inventor： Daniel Janssen , Carlo Boutton , Evelyne Dombrecht , Bram Laukens , Paolo Meoni , Lily Pao , Jan Pype , Peter Schotte , Benedikte Serruys , Ana Paula Vintem , Diane Van Hoorick
CPC classification number: C07K16/303 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/92 , C07K2319/30
Abstract: The present technology aims at providing a novel type of drug for treating a subject suffering from cancer. Specifically, the technology provides polypeptides comprising at least four immunoglobulin single variable domains (ISVDs), characterized in that one ISVD binds to TCR and at least two ISVDs bind to GPC3. The present technology also provides nucleic acids, vectors and compositions.
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公开(公告)号：US20230242620A1
公开(公告)日：2023-08-03
申请号：US18299871
申请日：2023-04-13
Applicant: Ablynx N.V. , Sanofi
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Néotère Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
CPC classification number: C07K16/00 , C07K16/18 , A61K2039/505
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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Patent Agency Ranking
公开(公告)号：US11644471B2
公开(公告)日：2023-05-09
申请号：US14138863
申请日：2013-12-23
Applicant: Ablynx N.V. , Sanofi
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
CPC classification number: G01N33/6857 , C07K16/18 , C07K16/2863 , C07K16/4258 , A61K2039/505 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US20210388062A1
公开(公告)日：2021-12-16
申请号：US17408937
申请日：2021-08-23
Applicant: Ablynx N.V.
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Néotère Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US11192937B2
公开(公告)日：2021-12-07
申请号：US15615197
申请日：2017-06-06
Applicant: Ablynx N.V.
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC: C07K16/00 , A61K39/00 , C07K16/28 , C07K16/42 , A61K39/395 , C07K16/18 , G01N33/53 , G01N33/543 , G01N33/68
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: —assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; —ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; —modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US20200216532A1
公开(公告)日：2020-07-09
申请号：US16822186
申请日：2020-03-18
Applicant: Ablynx N.V.
Inventor： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US20180355031A1
公开(公告)日：2018-12-13
申请号：US15975834
申请日：2018-05-10
Applicant: Ablynx N.V.
Inventor： JUDITH BAUMEISTER , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/00 , C07K16/2875 , C07K16/42 , C07K16/4283 , C07K2317/22 , C07K2317/31 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5306 , G01N33/6854
Abstract: This invention provides, and in certain specific but non-limiting aspects relates to:—assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal;—methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal;—modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal;—ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal;—modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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