公开(公告)号：US20140284496A1

公开(公告)日：2014-09-25

申请号：US14189040

申请日：2014-02-25

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： J. Michael Phillips ,  Kevin S. BODNER ,  Aldrich N. K. LAU ,  Mark F. OLDHAM ,  Donald R. SANDELL ,  David H. TRACY ,  Steven J. BOEGE

IPC: G01N21/01

CPC classification number: G01N21/278 ,  B82Y15/00 ,  G01J1/10 ,  G01N21/01 ,  G01N21/4785 ,  G01N21/6452 ,  G01N21/76 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0691 ,  G01N2201/0697 ,  Y10S977/943 ,  Y10S977/949

Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.

Abstract translation: 本教导提供了用于检测和/或分析光的系统及其组件。 这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

公开(公告)号：US20130224877A1

公开(公告)日：2013-08-29

申请号：US13765568

申请日：2013-02-12

Applicant: Applied Biosystems, LLC

Inventor： J. Michael PHILLIPS ,  Kevin S. BODNER ,  Aldrich N. K. LAU ,  Steven J. BOEGE ,  Mark F. OLDHAM ,  Donald R. SANDELL ,  David H. TRACY

IPC: G01J1/10

CPC classification number: G01N21/278 ,  B82Y15/00 ,  G01J1/10 ,  G01N21/01 ,  G01N21/4785 ,  G01N21/6452 ,  G01N21/76 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0691 ,  G01N2201/0697 ,  Y10S977/943 ,  Y10S977/949

Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.

Abstract translation: 本教导提供了用于检测和/或分析光的系统及其组件。 这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

公开(公告)号：US20160158749A1

公开(公告)日：2016-06-09

申请号：US14930213

申请日：2015-11-02

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Eugene F. YOUNG ,  Steven J. BOEGE ,  Donald R. SANDELL

IPC: B01L3/00

CPC classification number: B01L3/50851 ,  B01L3/50825 ,  B01L3/50853 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/168 ,  C12Q1/6806 ,  G01N21/0303

Abstract: A cover for a biological sample well tray, comprising a cap for sealing a sample well. The cap comprises a well lens for focusing light into the sample well and collecting light from the sample. In another aspect, the cap comprises an elongate portion configured to permit incoming light to pass into the sample well and out of the sample well. Various other aspects comprise a microcard for biological material, and an apparatus for a plurality of sample well strips. A method for testing a biological sample is also provided.

Abstract translation: 用于生物样品井托盘的盖子，包括用于密封样品井的盖子。 盖包括用于将光聚焦到样品阱中并收集来自样品的光的井透镜。 在另一方面，盖包括细长部分，该细长部分被配置成允许入射光进入样品阱并从样品阱中进入。 各种其它方面包括用于生物材料的微卡，以及用于多个样品阱条的装置。 还提供了用于测试生物样品的方法。

公开(公告)号：US20140096625A1

公开(公告)日：2014-04-10

申请号：US14103626

申请日：2013-12-11

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Donald R. SANDELL

IPC: B01L3/00

CPC classification number: B01L3/00 ,  B01F13/0064 ,  B01F13/0094 ,  B01F15/0205 ,  B01F15/021 ,  B01F15/0212 ,  B01L3/5025 ,  B01L3/502738 ,  B01L2300/0672 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2300/161 ,  B01L2400/0638 ,  B01L2400/0677 ,  Y10T436/2575

Abstract: A sample substrate configured for samples of biological material is provided. The sample substrate has a dual chambered sample well separated by a wall that may be punctured or otherwise breached to allow mixing of material contained in the two initially separate chambers. The chambers are connected by channels to fluid reservoirs, wherein the channels can be staked to prevent further fluid flow into and out of the chambers. Methods of loading a sample substrate are also provided.

Abstract translation: 提供了构造用于生物材料样品的样品衬底。 样品基底具有良好的壁分隔的双室样品，其可能被穿孔或以其它方式被破坏以允许混合在两个最初分离的室中的材料。 腔室通过通道连接到流体储存器，其中通道可以被放样以防止进一步的流体流入和流出腔室。 还提供了加载样品基底的方法。