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公开(公告)号：US20190290648A1
公开(公告)日：2019-09-26
申请号：US16347942
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong CHEN , Paul John DRANSFIELD , James S. HARVEY , Julie Anne HEATH , Jonathan HOUZE , Aarif Yusuf KHAKOO , David J. KOPECKY , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Philip Dean RAMSDEN
IPC: A61K31/506 , A61P9/04 , C07D403/12 , C07D405/14 , C07D401/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.
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公开(公告)号：US20170035744A1
公开(公告)日：2017-02-09
申请号：US15298748
申请日：2016-10-20
Applicant: AMGEN INC.
Inventor： Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. JUDD , Frank KAYSER
IPC: A61K31/4439 , C07D239/30 , C07D241/18 , C07D213/61 , A61K31/695 , A61K31/444 , A61K31/497 , A61K31/437 , A61K31/501 , A61K45/06 , C07C311/13 , C07D241/12 , C07D239/34 , C07D295/16 , A61K31/506 , C07D239/26
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20190290647A1
公开(公告)日：2019-09-26
申请号：US16347924
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong CHEN , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , James S. HARVEY , Jonathan HOUZE , Aarif Yusuf KHAKOO , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Philip Dean RAMSDEN , Ankit SHARMA
IPC: A61K31/506 , A61P9/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , A61K31/4439 , C07D405/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US20190284173A1
公开(公告)日：2019-09-19
申请号：US16347955
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Ning CHEN , Yinhong CHEN , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , James S. HARVEY , Julie Anne HEATH , Jonathan HOUZE , Aarif Yusuf KHAKOO , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Charles KREIMAN
IPC: C07D403/14 , C07D403/04 , C07D249/14 , C07D403/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D239/24 , C07D417/12 , C07D241/12 , A61P9/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US20190275008A1
公开(公告)日：2019-09-12
申请号：US16347903
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Matthew BROWN , Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , James S. HARVEY , Julie Anne HEATH , Lars V. HEUMANN , Jonathan HOUZE , Frank KAYSER , Aarif Yusuf KHAKOO , David j. KOPECKY , Su-Jen LAI , Zhihua MA , Julio C. MEDINA , Jeffrey T. MIHALIC , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Malgorzata WANSKA , Wen-Chen YEH
IPC: A61K31/4196 , C07D405/14 , C07D405/04 , A61K31/506 , C07D405/12 , C07D471/04 , A61K31/437 , C07F7/08 , A61K31/4439 , A61K31/501 , C07D413/12 , A61K31/421 , C07D239/26 , C07D403/12
Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.
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Patent Agency Ranking
公开(公告)号：US20170320860A1
公开(公告)日：2017-11-09
申请号：US15584109
申请日：2017-05-02
Applicant: AMGEN INC.
Inventor： Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , Zice FU , James S. HARVEY , Julie Anne HEATH , Simon J. HEDLEY , Jonathan HOUZE , Ted C. JUDD , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Wen-Chen YEH
IPC: C07D405/14 , C07D471/04 , C07D405/04 , A61K31/5383 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/4439 , C07D498/04 , A61K45/06
CPC classification number: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , C07D498/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20170042872A1
公开(公告)日：2017-02-16
申请号：US15297940
申请日：2016-10-19
Applicant: AMGEN INC.
Inventor： Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua Ma , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. Judd , Frank KAYSER
IPC: A61K31/4439 , A61K31/695 , A61K31/501 , A61K31/497 , A61K31/444 , A61K45/06 , A61K31/506
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Abstract translation: 其中在这里提供变量的定义。
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公开(公告)号：US20170042871A1
公开(公告)日：2017-02-16
申请号：US15297487
申请日：2016-10-19
Applicant: AMGEN INC.
Inventor： Ning Chen , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. JUDD , Frank KAYSER
IPC: A61K31/4439 , A61K31/501 , A61K31/444 , A61K31/506 , A61K31/497
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20170037026A1
公开(公告)日：2017-02-09
申请号：US15297272
申请日：2016-10-19
Applicant: AMGEN INC.
Inventor： Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. JUDD , Frank KAYSER
IPC: C07D401/04 , A61K31/4439 , C07F7/08 , A61K31/695 , C07D401/14 , C07D405/14 , C07B59/00 , C07D471/04 , A61K31/444 , C07D417/14 , A61K31/497 , A61K45/06 , A61K31/506
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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10.发明申请公开(公告)号：US20200325200A1
公开(公告)日：2020-10-15
申请号：US16918088
申请日：2020-07-01
Applicant: AMGEN INC.
Inventor： Yumei XIONG , Yang LI , Wen-Chen YEH , Bei SHAN , Jackie Zeqi SHENG
IPC: C07K14/495 , A61K38/18
Abstract: Methods of treating metabolic diseases and disorders using a GDF15 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes mellitus, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
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