专利检索 ap:("AMGEN INC.") AND inv:"Deborah Choquette" 第 1 页

1.

发明申请
FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：熔融杂环衍生物及其使用方法

公开(公告)号：US20130303529A1

公开(公告)日：2013-11-14

申请号：US13916984

申请日：2013-06-13

申请人： Amgen Inc.

发明人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia W. Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang , Karina Romero , Katrina Woodin Copeland , Emily A. Peterson

IPC分类号： C07D487/04 , A61K31/5377 , A61K31/5025 , A61K31/497 , A61K31/52 , A61K31/437 , A61K45/06 , C07D473/34 , C07D471/04 , A61K31/538 , A61K31/506

CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

2.

发明申请
AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE 有权
标题翻译：氨基二苯并恶嗪和氨基二氧化二硅杂环化合物作为β-分泌酶拮抗剂及其使用方法

公开(公告)号：US20150259308A1

公开(公告)日：2015-09-17

申请号：US14433769

申请日：2013-10-10

申请人： AMGEN INC.

发明人： Richard T. Lewis , Jennifer R. Allen , Yuan Cheng , Deborah Choquette , Oleg Epstein , Angel Guzman-Perez , Paul E. Harrington , Zihao Hua , Randall W. Hungate , Jason Brooks Human , Ted Judd , Qingyian Liu , Patricia Lopez , Ana Elena Minatti , Philip Olivieri , Karina Romero , Shannon Rumfelt , Robert M. Rzasa , Laurie Schenkel , John Stellwagen , Ryan White , Qiufen Xue , Xiao Mei Zheng , Wenge Zhong

IPC分类号： C07D279/12 , C07D471/04 , C07D239/74 , C07D495/04 , C07D213/79 , C07D513/10 , C07D417/12 , C07D417/14 , C07D513/04 , C07D498/04 , C07D279/14 , C07D417/04 , C07D241/44

CPC分类号： C07D279/12 , C07D213/79 , C07D239/74 , C07D241/44 , C07D279/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/10 , C07D519/00

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。化合物具有通式I：其中式I的变量A4，A5，A6，A8，R1，R2，R3，R7和n独立地在本文中定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由BACE的生物学活性产生的A-β斑块形成和沉积相关的病症和/或病症的化合物和组合物的相应用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II化合物及其次级实施方案，可用于制备式I-II化合物的中间体和方法和方法。

3.

发明授权
Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use 有权
标题翻译：氨基二氢噻嗪和氨基二氧化二氢噻嗪化合物作为β-分泌酶拮抗剂和使用方法

公开(公告)号：US09556135B2

公开(公告)日：2017-01-31

申请号：US14433769

申请日：2013-10-10

申请人： Amgen Inc.

发明人： Richard T. Lewis , Jennifer R. Allen , Yuan Cheng , Deborah Choquette , Oleg Epstein , Angel Guzman-Perez , Paul E. Harrington , Zihao Hua , Randall W. Hungate , Jason Brooks Human , Ted Judd , Qingyian Liu , Patricia Lopez , Ana Elena Minatti , Philip Olivieri , Karina Romero , Shannon Rumfelt , Robert M. Rzasa , Laurie Schenkel , John Stellwagen , Ryan White , Qiufen Xue , Xiao Mei Zheng , Wenge Zhong

IPC分类号： C07D279/12 , C07D417/04 , C07D471/04 , C07D239/74 , C07D495/04 , C07D213/79 , C07D241/44 , C07D417/12 , C07D417/14 , C07D513/04 , C07D498/04 , C07D513/10 , C07D279/14 , C07D519/00

CPC分类号： C07D279/12 , C07D213/79 , C07D239/74 , C07D241/44 , C07D279/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/10 , C07D519/00

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。化合物具有通式I：其中式I的变量A4，A5，A6，A8，R1，R2，R3，R7和n独立地在本文中定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由BACE的生物学活性产生的A-β斑块形成和沉积相关的病症和/或病症的化合物和组合物的相应用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II化合物及其次级实施方案，可用于制备式I-II化合物的中间体和方法和方法。