公开(公告)号：US20170285013A1

公开(公告)日：2017-10-05

申请号：US15591531

申请日：2017-05-10

Applicant: Alexion Pharmaceuticals, Inc.

Inventor： Mayur MOVALIA ,  Andrea ILLINGWORTH ,  Susan Faas MCKNIGHT ,  Russell P. ROTHER

IPC: G01N33/50 ,  G01N33/68 ,  C07K16/40 ,  A61K38/48 ,  A61K38/19 ,  G01N33/569 ,  A61K31/727 ,  A61K31/56 ,  A61K31/352 ,  A61K35/19

CPC classification number: G01N33/5094 ,  A61K31/352 ,  A61K31/56 ,  A61K31/727 ,  A61K35/19 ,  A61K38/196 ,  A61K38/4886 ,  C07K16/40 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2800/226

Abstract: The disclosure relates to methods for detecting PNH Type II cell populations in biological samples as well as methods for determining whether a patient is at an increased risk for developing thrombocytopenia or thrombosis based on the percentage of PNH Type II cells in the patient's blood. The disclosure also features reagents and conjugates for use in the methods.

公开(公告)号：US20140286962A1

公开(公告)日：2014-09-25

申请号：US14219218

申请日：2014-03-19

Applicant: ALEXION PHARMACEUTICALS, INC.

Inventor： Mayur MOVALIA ,  Andrea ILLINGWORTH ,  Susan FAAS MCKNIGHT ,  Russell P. ROTHER

IPC: G01N33/50 ,  A61K31/727 ,  C07K16/40 ,  A61K31/56 ,  A61K38/19 ,  A61K38/48 ,  A61K31/352 ,  A61K35/14

CPC classification number: G01N33/5094 ,  A61K31/352 ,  A61K31/56 ,  A61K31/727 ,  A61K35/19 ,  A61K38/196 ,  A61K38/4886 ,  C07K16/40 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2800/226

Abstract: The disclosure relates to methods for detecting PNH Type II cell populations in biological samples as well as methods for determining whether a patient is at an increased risk for developing thrombocytopenia or thrombosis based on the percentage of PNH Type II cells in the patient's blood. The disclosure also features reagents and conjugates for use in the methods.

Abstract translation: 本公开涉及用于检测生物样品中PNH II型细胞群的方法，以及用于基于患者血液中PNH II型细胞的百分比来确定患者是否处于发生血小板减少症或血栓形成的风险增加的方法。 本公开还涉及用于该方法的试剂和共轭物。