公开(公告)号：US12011619B2

公开(公告)日：2024-06-18

申请号：US17191497

申请日：2021-03-03

Applicant: Montefiore Medical Center ,  Albert Einstein College of Medicine

Inventor： Chandan Guha ,  Stephen Barry ,  Fernando Macian

IPC: A61N7/00 ,  A61B5/00 ,  A61B5/055 ,  A61K31/395 ,  A61K41/00 ,  A61N5/10 ,  A61P35/00 ,  A61B90/00 ,  A61N5/00

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B5/4836 ,  A61K31/395 ,  A61K41/0033 ,  A61N5/10 ,  A61N5/1077 ,  A61P35/00 ,  A61B2090/374 ,  A61B2090/378 ,  A61N2005/002 ,  A61N2005/1061 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0043 ,  A61N2007/0065 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: Systems and methods for treating cancer and for preventing metastasis using low intensity focused ultrasound in combination with an anti-cancer therapy are disclosed.

公开(公告)号：US11092591B2

公开(公告)日：2021-08-17

申请号：US15518284

申请日：2015-11-13

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE

Inventor： Aaron Alain-Jon Golden ,  Pilib Ó Broin ,  Chandan Guha ,  Irwin Kurland

IPC: G01N33/49 ,  G01T1/04 ,  G01N30/72 ,  G01N33/68 ,  G01N30/88

Abstract: Provided are methods of determining prior radiation dose exposure levels for subjects, and kits therefor. Also provided are methods of treatment.

公开(公告)号：US09907982B2

公开(公告)日：2018-03-06

申请号：US15279514

申请日：2016-09-29

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. ,  SONACARE MEDICAL, LLC

Inventor： Narendra T. Sanghvi ,  Chandan Guha ,  Russell James Fedewa ,  Roy Francis Carlson ,  Ralf Seip ,  Wo-Hsing Chen

IPC: A61B8/00 ,  A61N7/02 ,  A61B8/08 ,  A61B18/04 ,  A61B10/00 ,  A61B17/225 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B8/08 ,  A61B8/0833 ,  A61B10/0051 ,  A61B10/007 ,  A61B18/04 ,  A61B2017/2253 ,  A61N2007/0004 ,  A61N2007/0073 ,  A61N2007/0082

Abstract: A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

公开(公告)号：US20170014651A1

公开(公告)日：2017-01-19

申请号：US15279514

申请日：2016-09-29

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. ,  SONACARE MEDICAL, LLC

Inventor： Narendra T. Sanghvi ,  Chandan Guha ,  Russell James Fedewa ,  Roy Francis Carlson ,  Ralf Seip ,  Wo-Hsing Chen

IPC: A61N7/02 ,  A61B18/04 ,  A61B8/08

CPC classification number: A61N7/02 ,  A61B8/08 ,  A61B8/0833 ,  A61B10/0051 ,  A61B10/007 ,  A61B18/04 ,  A61B2017/2253 ,  A61N2007/0004 ,  A61N2007/0073 ,  A61N2007/0082

Abstract: A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

Abstract translation: 提供了使用高强度聚焦超声诊断和治疗肿瘤的方法。 诊断患者肿瘤存在的方法包括以下步骤：使肿瘤进行高强度聚焦超声（HIFU）以使肿瘤细胞释放细胞物质并评估肿瘤标志物的细胞材料。 治疗患者肿瘤的方法还可以包括使肿瘤进行高强度聚焦超声（HIFU）以引起免疫应答的步骤。

公开(公告)号：US10801065B2

公开(公告)日：2020-10-13

申请号：US15546337

申请日：2016-02-09

Applicant: Dana-Farber Cancer Institute, Inc. ,  Albert Einstein College of Medicine, Inc.

Inventor： Dipanjan Chowdhury ,  Chandan Guha

IPC: C12Q1/6876 ,  C12Q1/6883 ,  G01N33/50

Abstract: Provided herein are methods of determining a subject's level of exposure to radiation and methods of determining a subject's risk of subsequent development of radiation disease or risk of poor prognosis from radiation exposure that include determining a level of one or more miRNAs selected from the group consisting of mouse and human homologues of mouse miR-130a-3p, miR-150-5p, miR-17-3p, miR-187-3p, miR-194-5p, miR-27a-3p, miR-30a-3p, miR-30c-5p, miR-142-5p, miR-342-3p, miR-34b-3p, miR-126-3p, miR-320-3p, miR-136-5p, miR-33-5p, miR-142a-3p, miR-706, miR-375-3p, miR-29a-5p, miR-193a-3p, miR-99b-5p, miR-151-3p, miR-let-7d-3p, miR-486-5p, miR-423-5p, miR-30b-5p, miR-191-5p, miR-497a-5p, miR-32-5p, miR-214-5p, miR-326-3p, miR-1195, miR-122-5p, miR-1839-3p, miR-500-3p, miR-30e-3p, miR-322-3p, miR-709, miR-486-3p, miR-133a-3p, miR-676-3p, miR-744-5p, miR-29a-3p, miR-1839-5p, miR-30a-5p, miR-199b-5p, miR-125a-5p, miR-133b-3p, miR-24-3p, miR-21a-5p, miR-503-5p, miR-328-3p, miR-let-7g-5p, miR-362-3p, miR-199a-5p, miR-15a-3p, miR-139-5p, miR-149-5p, miR-29b-3p, miR-1a-3p, miR-23b-3p, miR-215-5p, miR-204-5p, miR-200b-5p, miR-25-3p, miR-338-3p, and miR-196b-5p, in a sample including a biological fluid from the subject.

公开(公告)号：US10772846B2

公开(公告)日：2020-09-15

申请号：US15520156

申请日：2015-11-02

Applicant: Montefiore Medical Center ,  Albert Einstein College of Medicine

Inventor： Hui B. Sun ,  Daniel J. Leong ,  Neil J. Cobelli ,  David M. Hirsh ,  John A. Hardin ,  Karen E. Sperling ,  Sun Jin Kim ,  David C. Spray ,  Chandan Guha ,  Marwa Choudhury

IPC: A61K31/353 ,  A61K31/12 ,  A61P19/02 ,  A61K31/05 ,  A61K9/00

Abstract: Methods and formulations are provided for treating or preventing arthritis, in particular osteoarthritis, where the formulation to be administered to a subject for treating or preventing arthritis comprises carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins. The invention provides methods of treating or preventing arthritis, such as osteoarthritis, in a subject in need thereof comprising administering to the subject a formulation or composition comprising carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins in an amount effective to treat or prevent arthritis.

公开(公告)号：US09439947B2

公开(公告)日：2016-09-13

申请号：US14666746

申请日：2015-03-24

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

Inventor： Chandan Guha ,  Subhrajit Saha

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/435 ,  C07K14/075 ,  A61K35/761 ,  A61K48/00

CPC classification number: A61K38/1709 ,  A61K35/761 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0083 ,  C07K14/075 ,  C07K14/435 ,  C07K14/4702 ,  C12N2710/10343

Abstract: Methods are disclosed for therapy of radiation-induced lung injury and other lung diseases using R-spondin1.

Abstract translation: 公开了使用R-spondin1治疗放射诱导的肺损伤和其它肺部疾病的方法。

公开(公告)号：US20150306177A1

公开(公告)日：2015-10-29

申请号：US14666746

申请日：2015-03-24

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY

Inventor： Chandan Guha ,  Subhrajit Saha

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K35/761 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0083 ,  C07K14/075 ,  C07K14/435 ,  C07K14/4702 ,  C12N2710/10343

Abstract: Methods are disclosed for therapy of radiation-induced lung injury and other lung diseases using R-spondin1.

Abstract translation: 公开了使用R-spondin1治疗放射诱导的肺损伤和其它肺部疾病的方法。

公开(公告)号：US10974077B2

公开(公告)日：2021-04-13

申请号：US15578892

申请日：2016-06-02

Applicant: Montefiore Medical Center ,  Albert Einstein College of Medicine, Inc.

Inventor： Chandan Guha ,  Stephen Barry ,  Fernando Macian

IPC: A61N7/00 ,  A61N5/10 ,  A61B5/055 ,  A61B5/00 ,  A61N5/00 ,  A61B90/00

Abstract: Systems and methods for treating cancer and for preventing metastasis using low intensity focused ultrasound in combination with an anti-cancer therapy are disclosed.

公开(公告)号：US20210079467A1

公开(公告)日：2021-03-18

申请号：US17005548

申请日：2020-08-28

Applicant: Dana-Farber Cancer Institute, Inc. ,  Albert Einstein College of Medicine, Inc.

Inventor： Dipanjan Chowdhury ,  Chandan Guha

IPC: C12Q1/6876 ,  C12Q1/6883 ,  G01N33/50

Abstract: Provided herein are methods of determining a subject's level of exposure to radiation and methods of determining a subject's risk of subsequent development of radiation disease or risk of poor prognosis from radiation exposure that include determining a level of one or more miRNAs selected from the group consisting of mouse and human homologues of mouse miR-130a-3p, miR-150-5p, miR-17-3p, miR-187-3p, miR-194-5p, miR-27a-3p, miR-30a-3p, miR-30c-5p, miR-142-5p, miR-342-3p, miR-34b-3p, miR-126-3p, miR-320-3p, miR-136-5p, miR-33-5p, miR-142a-3p, miR-706, miR-375-3p, miR-29a-5p, miR-193a-3p, miR-99b-5p, miR-151-3p, miR-let-7d-3p, miR-486-5p, miR-423-5p, miR-30b-5p, miR-191-5p, miR-497a-5p, miR-32-5p, miR-214-5p, miR-326-3p, miR-1195, miR-122-5p, miR-1839-3p, miR-500-3p, miR-30e-3p, miR-322-3p, miR-709, miR-486-3p, miR-133a-3p, miR-676-3p, miR-744-5p, miR-29a-3p, miR-1839-5p, miR-30a-5p, miR-199b-5p, miR-125a-5p, miR-133b-3p, miR-24-3p, miR-21a-5p, miR-503-5p, miR-328-3p, miR-let-7g-5p, miR-362-3p, miR-199a-5p, miR-15a-3p, miR-139-5p, miR-149-5p, miR-29b-3p, miR-1a-3p, miR-23b-3p, miR-215-5p, miR-204-5p, miR-200b-5p, miR-25-3p, miR-338-3p, and miR-196b-5p, in a sample including a biological fluid from the subject.