公开(公告)号：US12011619B2

公开(公告)日：2024-06-18

申请号：US17191497

申请日：2021-03-03

Applicant: Montefiore Medical Center ,  Albert Einstein College of Medicine

Inventor： Chandan Guha ,  Stephen Barry ,  Fernando Macian

IPC: A61N7/00 ,  A61B5/00 ,  A61B5/055 ,  A61K31/395 ,  A61K41/00 ,  A61N5/10 ,  A61P35/00 ,  A61B90/00 ,  A61N5/00

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B5/4836 ,  A61K31/395 ,  A61K41/0033 ,  A61N5/10 ,  A61N5/1077 ,  A61P35/00 ,  A61B2090/374 ,  A61B2090/378 ,  A61N2005/002 ,  A61N2005/1061 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0043 ,  A61N2007/0065 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: Systems and methods for treating cancer and for preventing metastasis using low intensity focused ultrasound in combination with an anti-cancer therapy are disclosed.

公开(公告)号：US20240002941A1

公开(公告)日：2024-01-04

申请号：US18254242

申请日：2021-12-02

Applicant: Albert Einstein College of Medicine ,  Montefiore Medical Center ,  Johannes Gutenberg University (JGU) Medical Center

Inventor： Yaron Tomer ,  Larissa C. Faustino ,  George J. Kahaly

IPC: C12Q1/6883 ,  C07K16/28 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  C07K16/2878 ,  G01N33/6893 ,  C12Q2600/106 ,  G01N2800/52 ,  C12Q2600/158 ,  G01N2333/70578 ,  G01N2800/24 ,  C12Q2600/156

Abstract: Methods of predicting response of a subject in need of immunosuppressant therapy to a Cluster of differentiation 40 (CD40)-targeted treatment are disclosed. The methods permit treating the subject with a treatment most likely to show a favorable response.

公开(公告)号：US20220306722A1

公开(公告)日：2022-09-29

申请号：US17633173

申请日：2020-08-04

Applicant: Icahn School of Medicine at Mount Sinai ,  Montefiore Medical Center ,  Albert Einstein College of Medicine, Inc.

Inventor： Yaron Tomer ,  Roman Osman ,  Angela Lombardi

IPC: C07K14/74 ,  C07K7/06

Abstract: The disclosure provides polypeptides that specifically bind to HLA-DQ8 for treating Type 1 Diabetes (TID) and methods using same for reducing autoimmune destruction of pancreatic islet beta cells. In particular, the present disclosure relates to peptides containing at least one D-amino acid that are capable of blocking the presentation of antigenic islet peptides (e.g., lnsB:9-23) by HLA-DQ8, and to their uses, especially as it relates to the prevention and/or treatment of TID.

公开(公告)号：US20210077832A1

公开(公告)日：2021-03-18

申请号：US16961436

申请日：2019-01-25

Applicant: Celldex Therapeutics, Inc. ,  Montefiore Medical Center ,  Albert Einstein College of Medicine

Inventor： Tibor KELER ,  Michael YELLIN ,  Chandan GUHA ,  Nitin OHRI

IPC: A61N5/10 ,  A61P35/00 ,  C07K16/28 ,  A61K38/17 ,  A61K45/06 ,  A61K39/395

Abstract: Methods of treating cancer comprising administering to patients a dendritic cell mobilizing agent (e.g., Flt3 ligand) in combination with radiation and/or immunoregulatory agents (e.g., checkpoint inhibitors), are disclosed.

公开(公告)号：US20190249163A1

公开(公告)日：2019-08-15

申请号：US16283468

申请日：2019-02-22

Applicant: The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

Inventor： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC: C12N9/52 ,  A61K47/64 ,  A61K38/29 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K14/50 ,  A61K8/49 ,  A61K8/65 ,  A61Q7/00 ,  A61K8/99 ,  A61Q7/02 ,  A61K8/64 ,  A61K38/18 ,  A61K38/27 ,  A61K39/395 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/51 ,  A61K8/66 ,  A61K38/17 ,  A61K38/19 ,  A61K38/30 ,  A61K39/44

CPC classification number: C12N9/52 ,  A61K8/4913 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/99 ,  A61K38/00 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/193 ,  A61K38/27 ,  A61K38/29 ,  A61K38/30 ,  A61K39/3955 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  A61K2039/6031 ,  A61K2800/57 ,  A61Q7/00 ,  A61Q7/02 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K2319/31 ,  C07K2319/70 ,  C07K2319/74 ,  C12Y304/24003

Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US20180169037A1

公开(公告)日：2018-06-21

申请号：US15735214

申请日：2016-06-27

Applicant: Montefiore Medical Center

Inventor： Richard M. LoPachin ,  Terrence Gavin

IPC: A61K31/12 ,  A61P39/06 ,  A61K31/167 ,  A61K31/5375 ,  A61K31/381 ,  A61K31/495 ,  A61K31/402 ,  C07C49/825 ,  C07C49/84 ,  C07C49/80 ,  C07C49/807 ,  C07C233/33 ,  C07C323/22 ,  C07D295/112 ,  C07D333/22 ,  C07D207/04 ,  C07D207/325 ,  A01N1/02

CPC classification number: A61K31/12 ,  A01N1/0226 ,  A61K31/05 ,  A61K31/095 ,  A61K31/167 ,  A61K31/36 ,  A61K31/381 ,  A61K31/402 ,  A61K31/495 ,  A61K31/5375 ,  A61P39/06 ,  C07C49/80 ,  C07C49/807 ,  C07C49/825 ,  C07C49/84 ,  C07C233/33 ,  C07C323/22 ,  C07D207/04 ,  C07D207/325 ,  C07D295/112 ,  C07D333/22 ,  A61K2300/00

Abstract: Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

公开(公告)号：US20170106093A1

公开(公告)日：2017-04-20

申请号：US15386626

申请日：2016-12-21

Applicant: The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER

Inventor： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure

IPC: A61P5/18 ,  A61K38/48 ,  A61K38/29

CPC classification number: A61K38/48 ,  A61K38/29 ,  A61K47/56 ,  A61K47/64 ,  C12Y304/00

Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US09579273B2

公开(公告)日：2017-02-28

申请号：US14365226

申请日：2012-12-14

Applicant: The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

Inventor： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC: A61K8/65 ,  A61K8/99 ,  A61K38/29 ,  C07K14/635 ,  A61Q7/00 ,  A61K8/66 ,  A61K47/48 ,  A61K8/49 ,  A61K8/64 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/30 ,  A61K39/44 ,  A61Q7/02 ,  A61K39/00

CPC classification number: C12N9/52 ,  A61K8/4913 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/99 ,  A61K38/00 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/193 ,  A61K38/27 ,  A61K38/29 ,  A61K38/30 ,  A61K39/3955 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  A61K2039/6031 ,  A61K2800/57 ,  A61Q7/00 ,  A61Q7/02 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K2319/31 ,  C07K2319/70 ,  C07K2319/74 ,  C12Y304/24003

Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Abstract translation: 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 在这些方法中，治疗剂不是PTH / PTHrP受体激动剂或拮抗剂，碱性成纤维细胞生长因子（bFGF）或表皮生长因子（EGF）。 细菌胶原结合多肽片段将药物递送到部分未扭曲或扭曲不足的胶原蛋白部位。 还提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗胶原病的方法。 此外，提供使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 最后，提供通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。

公开(公告)号：US20150038423A1

公开(公告)日：2015-02-05

申请号：US14378067

申请日：2013-02-11

Applicant: The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  Montefiore Medical Center

Inventor： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure

IPC: A61K38/29 ,  A61K47/48

CPC classification number: A61K38/48 ,  A61K38/29 ,  A61K47/56 ,  A61K47/64 ,  C12Y304/00

Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Abstract translation: 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 此外，提供了通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。

公开(公告)号：US20250041631A1

公开(公告)日：2025-02-06

申请号：US18773093

申请日：2024-07-15

Applicant: Montefiore Medical Center

Inventor： Chandan GUHA ,  Stephen BARRY

IPC: A61N7/00 ,  A61B8/00 ,  A61B8/08 ,  A61B18/00 ,  A61B90/00 ,  A61K49/22 ,  A61N5/02 ,  A61N7/02 ,  C07K14/71 ,  C07K16/28

Abstract: Disclosed herein are the systems, devices and methods for treating cancer and metastasis using low energy immune priming. The low energy immune priming includes administering immunopriming energy. The low energy immune priming can be combined with an adjunct therapy.