公开(公告)号：US20170189493A1

公开(公告)日：2017-07-06

申请号：US15351317

申请日：2016-11-14

Applicant: RADIUS HEALTH, INC. ,  3M INNOVATIVE PROPERTIES COMPANY, a wholly owned subsidiary of 3M COMPANY

Inventor： Gary HATTERSLEY ,  Kris J. HANSEN ,  Amy S. DETERMAN ,  Ying ZHANG

IPC: A61K38/29 ,  A61M37/00

Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.

公开(公告)号：US20200030486A1

公开(公告)日：2020-01-30

申请号：US16338140

申请日：2017-10-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jonathan J. O'HARE ,  Mikhail L. PEKUROVSKY ,  Amy S. DETERMAN ,  Gino L. PITERA ,  Jason W. BJORK ,  Daniel V. NORTON ,  Robert A. ASMUS

IPC: A61L26/00 ,  B29C43/24

Abstract: A method of forming a fibrin hydrogel composition including providing one or more unitary masses of a fibrin hydrogel, dividing at least one of the unitary masses of the fibrin hydrogel into a multiplicity of smaller pieces of the fibrin hydrogel, and recombining at least a portion of the smaller pieces into a cohesive mass. Dividing at least one of the unitary masses of fibrin hydrogel into a multiplicity of smaller pieces may include shearing or cutting the unitary masses to form an aqueous dispersion of the fibrin hydrogel in an aqueous medium. The aqueous dispersion of fibrin hydrogel may be applied to a substrate on a roller or an endless belt, and is optionally overlaid by a scrim. The cohesive mass of fibrin hydrogel, which may be formed by removing at least a portion of the aqueous medium from the aqueous dispersion of the smaller pieces of the fibrin hydrogel, finds uses in wound dressing articles.