公开(公告)号：US20240285756A1

公开(公告)日：2024-08-29

申请号：US18424381

申请日：2024-01-26

Applicant: ZELARION MALTA LIMITED

Inventor： David Berglund ,  Erik Berglund

IPC: A61K39/395 ,  A61K31/436 ,  A61K31/573 ,  A61K31/675 ,  A61K31/7076 ,  A61K35/12 ,  A61K35/28 ,  A61K39/00 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/436 ,  A61K31/573 ,  A61K31/675 ,  A61K31/7076 ,  A61K35/28 ,  C07K16/2803 ,  C07K16/2887 ,  A61K2035/122 ,  A61K2039/507 ,  A61K2039/577

Abstract: Provided herein are methods for inducing tolerance to an organ or tissue transplant in a patient. Specifically, provided herein are methods for inducing temporary mixed chimerism in a transplant-eligible patient, wherein the method comprises administering an anti-CD2 antibody or antigen binding fragment thereof to the patient, transplanting bone marrow from a donor to the patient; and administering at least one other agent prior to and/or after transplant to the patient.

公开(公告)号：US20240270845A1

公开(公告)日：2024-08-15

申请号：US18439510

申请日：2024-02-12

Applicant: ZELARION MALTA LIMITED

Inventor： David Berglund ,  Erik Berglund ,  Felix Sellberg ,  Christian Binder

IPC: C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06 ,  A61P37/06

CPC classification number: C07K16/2806 ,  A61K38/1774 ,  A61K39/3955 ,  A61K45/06 ,  A61P37/06 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Provided herein are improved anti-CD2 antibodies and methods for their use in the treatment and/or prevention of chronic or acute disorders of the immune system. Also provided herein are methods for treating or preventing an immune related disorder or disease in a subject by administering an anti-CD2 antibody or an antigen-binding fragment thereof and a CTLA-4 co-stimulation blockade. Compositions for use with these methods and kits are also disclosed.

公开(公告)号：US20240101671A1

公开(公告)日：2024-03-28

申请号：US18273725

申请日：2022-01-20

Applicant: Zelarion Malta Limited

Inventor： Erik BERGLUND

IPC: C07K16/28 ,  A61K31/436 ,  A61K31/5355 ,  A61K31/573 ,  A61K31/675 ,  A61K35/407 ,  A61K39/395 ,  A61P37/06

CPC classification number: C07K16/2806 ,  A61K31/436 ,  A61K31/5355 ,  A61K31/573 ,  A61K31/675 ,  A61K35/407 ,  A61K39/3955 ,  A61P37/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

Abstract: Provided herein are methods for inducing tolerance to an organ (e.g., liver) transplant in a patient. Compositions for use with these methods and kits are also disclosed.

公开(公告)号：US20230365687A1

公开(公告)日：2023-11-16

申请号：US18012089

申请日：2021-06-22

Applicant: Zelarion Malta Limited

Inventor： David Berglund ,  Erik Berglund ,  Felix Sellberg ,  Christian Binder

IPC: C07K16/28 ,  A61P37/06 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2806 ,  A61P37/06 ,  A61K38/1774 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/732 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2319/30 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/734

Abstract: Provided herein are improved anti-CD2 antibodies and methods for their use in the treatment and/or prevention of chronic or acute disorders of the immune system. Also provided herein are methods for treating or preventing an immune related disorder or disease in a subject by administering an anti-CD2 antibody or an antigen-binding fragment thereof and a CTLA-4 co-stimulation blockade. Compositions for use with these methods and kits are also disclosed.