摘要:
The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要:
Apparatuses and methods for managing a process that include schedule management, quality, and process management features. Information is stored on an authorized person in charge and a conformity standard for the work to be managed. From this information, a managing method of the work to be managed from among a plurality of managing methods classified in advance is determined. Processes are determined for each management method, and a time limit determined by the authorized person in charge for each managed process. Adherence standards related to the managed processes are included, as well as records made of the process information including the performance quality of the managed process.
摘要:
Correspondences between logical blocks and physical blocks of first and second memories are controlled such that an identical logical block is subject to correspondence with a physical block of the first memory and to a physical block of the second memory, and data is stored in the physical blocks subject to correspondence with the identical logical block such that pages that contain data do not overlap between the physical blocks so that operation performed on the first memory and operation performed on the second memory can be performed in parallel, thereby achieving speedup and an increase in efficiency in data writing to non-volatile memory, to which overwriting is inapplicable and to which writing involves block-to-block data move.
摘要:
Herein disclosed is an endless hot rolling method using a hot strip mill substantially composed of a roughing mill and a finishing mill having a roll bender and a roll shifter to continuously roll sequentially joined different rolling materials. The method comprises the steps of: calculating a roll shift range in an axial direction for each rolling material so as to provide a desired crown; determining a rolling sequence so as to obtain a common roll shift range for each pair of neighboring rolling materials; connecting a preceding material at the tail end thereof to the head end of the succeeding material, between the roughing mill and the finishing mill; shifting the rolls during transition from the preceding material to the succeeding material so that the roll position corresponding to the joint of the two materials is within a common roll shift range for the materials; and changing the roll bending load in accordance with the roll shift pattern so as to achieve the desired crown of each material. If the width of a common roll shift range for all the materials is at least 50% of the width of the individual roll shift ranges, rolling can be continuously performed without shifting in an axial direction rolls.
摘要:
[Object]It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means]A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
摘要:
A multi-roll cluster rolling apparatus has a pair of work rolls, and a plurality of first intermediate rolls, a plurality of second intermediate rolls and a plurality of backup rolls arranged successively in the mentioned order behind each the work roll. A roll crown presented by unidirectinally tapering one end of a roll is imparted to at least a pair of rolls, e.g., the work rolls, selected from a roll group consisting of the work rolls, first intermediate rolls and the second intermediate rolls. A roll crown approximated by at least one-pitch portion of a waveform is imparted to at least one other pair of rolls, e.g., pairs of the first intermediate rolls. A roll crown approximated by at least two-pitch portion of a waveform is imparted to at least one of the remainder pairs of rolls, e.g., selected pairs of the second intermediate rolls. The rolls of each pair having the same roll crown arranged arranged in opposite axial directions and are axially shiftably mounted on a mill housing.
摘要:
To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.
摘要:
To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要:
[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
摘要:
An e-mail sending and receiving system in which positional data about a plurality of places can be included in an e-mail message to be sent, and further detailed data can be obtained based on the included positional data, thereby improving the convenience and effectiveness of the positional data. The system includes a mail generating section for generating an e-mail message to be sent to an addressee; a positional data storage section for storing a plurality of positional data; and a positional data attaching section for attaching one or more of the positional data stored in the positional data storage section to the e-mail message generated by the mail generating section. The system may further include a section for generating detailed data relating to each positional data attached to the e-mail message, and attaching a URL for accessing the detailed data to the e-mail message.