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公开(公告)号:US07384928B2
公开(公告)日:2008-06-10
申请号:US10507502
申请日:2003-03-18
IPC分类号: C07D501/46 , A61K31/546 , A61P31/04 , C07D277/593
CPC分类号: C07D501/56 , A61K31/546 , C07D501/00
摘要: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译: 下式的化合物:其中T是S,SO或O; X是卤素,CN,任选被低级烷基,低级烷基,低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基(其中取代基是 任选取代的单低级烷基,任选取代的低级亚烷基或任选取代的低级亚烷基); Z +是任选取代的阳离子和含N原子的杂环基),酯,氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。
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公开(公告)号:US20070219191A1
公开(公告)日:2007-09-20
申请号:US10591398
申请日:2005-03-03
IPC分类号: C07D501/56
CPC分类号: C07D501/00
摘要: A compound of Formula 1: (wherein A is optionally substituted lower alkylene (substituent: mono- or di-lower alkyl, lower alkylidene, or lower alkylene having two or more carbons); Z+ is either of the groups shown below: (wherein R1 and R2 are each independently hydrogen, optionally substituted amino lower alkyl, optionally substituted aminocycloalkyl, optionally substituted cyclic amino, or optionally substituted cyclic amino lower alkyl; R9 is hydrogen or lower alkyl, or R1 and R9 taken together with an adjacent N atom may form optionally substituted cyclic amino; R3 is hydrogen or amino; X is N or CR4 (R4 is hydrogen or optionally substituted lower alkyl)), a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译: 式1的化合物:(其中A是任选取代的低级亚烷基(取代基:一或二低级烷基,低级亚烷基或具有两个或更多个碳的低级亚烷基); Z + 下列基团:(其中R 1和R 2各自独立地为氢,任选取代的氨基低级烷基,任选取代的氨基环烷基,任选取代的环状氨基或任选取代的环状氨基 氨基低级烷基; R 9是氢或低级烷基,或者R 1和R 9与相邻的N原子一起可以形成任选取代的 环状氨基; R 3是氢或氨基; X是N或CR 4(R 4是氢或任选取代的低级烷基)), 其药学上可接受的盐或其溶剂合物。
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公开(公告)号:US6091902A
公开(公告)日:2000-07-18
申请号:US257378
申请日:1999-02-25
申请人: Hiroshi Komatsuzaki , Yasuhiro Nishitani , Yoichi Iwasaki , Hiroshi Omura , Osamu Inaba , Takashi Suzuki , Hideo Kobayashi
发明人: Hiroshi Komatsuzaki , Yasuhiro Nishitani , Yoichi Iwasaki , Hiroshi Omura , Osamu Inaba , Takashi Suzuki , Hideo Kobayashi
CPC分类号: G02B7/102 , G03B2206/004
摘要: A zoom camera with a pseudo zooming function for assigning a frame a pseudo zoom ratio by which a printing area and a print magnification of the frame are modified to obtain a photo print that looks like being photographed at a virtual focal length that is equal to a multiplication product of the pseudo zoom ratio and an actual focal length of a taking lens used for photographing the frame. A virtual focal length is determined in accordance with operating direction and amount of a manual zooming operation member. A viewfinder is controlled in correspondence with the virtual focal length, to show a photographic field to be contained in a photo print as photographed at the virtual focal length. In accordance with a predetermined relationship between virtual focal length and actual focal length and pseudo zoom ratio, actual focal length of the taking lens is changed depending upon the virtual focal length, and a pseudo zoom ratio is decided to each frame depending upon the virtual focal length determined at the photography of that frame. The pseudo zoom ratio is recorded in association with the photographed frame.
摘要翻译: 一种具有伪缩放功能的变焦相机,用于为帧分配伪缩放比例,通过该缩放倍数对帧的打印区域和打印放大率进行修改,以获得在虚拟焦距等于或等于1的像素拍摄的照片打印 伪变焦比的乘积和用于拍摄帧的拍摄镜头的实际焦距。 根据手动变焦操作构件的操作方向和量来确定虚拟焦距。 与虚拟焦距相对应地控制取景器,以示出要被包含在以虚拟焦距拍摄的照片打印中的照相场。 根据虚拟焦距与实际焦距和伪变焦比之间的预定关系,取决镜头的实际焦距根据虚拟焦距而改变,并且根据虚拟焦点对每帧进行伪缩放比率 在该帧的摄影时确定的长度。 与拍摄的帧相关联地记录伪变焦比。
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公开(公告)号:US5717308A
公开(公告)日:1998-02-10
申请号:US733473
申请日:1996-10-18
IPC分类号: G03B7/26 , G03B17/18 , G03B17/56 , H01M6/50 , H01M10/0525 , H01M10/46 , H01M16/00 , H02J7/00 , H02J9/06
CPC分类号: H01M6/5033 , G03B17/18 , G03B7/26 , H01M10/46 , H01M16/00 , H02J7/0047 , H02J7/0054 , H02J9/061 , H01M10/0525 , H01M6/5016 , Y02E60/122 , Y10S320/21 , Y10T307/625
摘要: In electric-supply equipment of the present invention, a main battery supplies electric power to equipment such as a camera, and an auxiliary battery such as an AA battery is used as a charging power source in order to supply electric energy to the main battery in a charging circuit. Thereby, if the power source (the auxiliary battery) has been consumed, only the auxiliary battery, which is inexpensive and easy to get, is replaced. In particular, a metal lithium secondary battery is used as the main battery, so that the main battery can supply a large amount of high current to the equipment such as a camera. Furthermore, the metal lithium secondary battery spontaneously discharges only a small amount of electricity, so that the battery need not be replaced even after a long period of non-use, and the equipment can be used anytime.
摘要翻译: 在本发明的供电设备中,主电池向诸如照相机的设备供电,并且使用诸如AA电池的辅助电池作为充电电源,以便向主电池供电 充电电路。 因此,如果电源(辅助电池)已经被消耗,则仅更换便宜且容易获得的辅助电池。 特别地,使用金属锂二次电池作为主电池,使得主电池可以向诸如照相机的设备提供大量的高电流。 此外,金属锂二次电池自发地仅释放少量电力,使得即使在长时间不使用之后也不需要更换电池,并且可以随时使用设备。
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公开(公告)号:US5703243A
公开(公告)日:1997-12-30
申请号:US574863
申请日:1995-12-19
申请人: Yasuhiro Nishitani , Tadashi Irie , Yutaka Nishino
发明人: Yasuhiro Nishitani , Tadashi Irie , Yutaka Nishino
IPC分类号: B01J31/02 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/495 , A61P31/04 , C07B61/00 , C07C307/04 , C07D207/08 , C07D207/12 , C07D207/26 , C07D207/273 , C07D333/20 , C07D401/12 , C07D403/12 , C07D417/06 , C07D477/00 , C07D477/02 , C07D477/14 , C07D477/20 , C07D501/00 , C07D501/04 , C07D501/16 , C07D501/22 , C07D501/46 , C07F7/10 , C07F9/572 , C08L63/00
CPC分类号: C07D207/273 , C07C307/04 , C07D207/12 , C07D477/02 , C07D477/14 , C07D477/20 , C07D501/00 , C08L63/00 , Y02P20/55
摘要: A pyrrolidylthiocarbapenem derivative represented by Formula I is provided: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2, R.sup.3 and R.sup.4 are hydrogen, lower alkyl which can be substituted or an amino protecting group independently, or R.sup.2 and R.sup.3 together with a nitrogen atom to which R.sup.2 and R.sup.3 are bonded form a saturated or unsaturated cyclic group, or R.sup.2 and R.sup.4, or R.sup.3 and R.sup.4 together with two nitrogen atoms and one sulfur atom in the sufamide group form a saturated or unsaturated cyclic group; each cyclic group can further include at least one atom selected from the group consisting of oxygen, sulfur and nitrogen, and each cyclic group can be substituted; X.sup.1 is hydrogen or a hydroxy protecting group; X.sup.2 is hydrogen, a carboxy protecting group, an ammonio group, an alkali metal or an alkaline-earth metal; and Y.sup.2 is hydrogen or an amino protecting group.
摘要翻译: 提供由式I表示的吡咯烷基硫代碳青霉烯衍生物:其中R 1是氢或低级烷基; R2,R3和R4是氢,可以被取代的低级烷基或氨基保护基,R2或R3与R2和R3所连接的氮原子一起形成饱和或不饱和的环状基团,或者R 2和R 4, 或R3和R4与磺酰胺基团中的两个氮原子和一个硫原子一起形成饱和或不饱和的环状基团; 每个环状基团可进一步包括至少一个选自氧,硫和氮的原子,并且每个环状基团可被取代; X1是氢或羟基保护基; X2是氢,羧基保护基,铵基,碱金属或碱土金属; 而Y2是氢或氨基保护基。
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公开(公告)号:US5317016A
公开(公告)日:1994-05-31
申请号:US929961
申请日:1992-08-14
申请人: Yasuhiro Nishitani , Tadashi Irie
发明人: Yasuhiro Nishitani , Tadashi Irie
IPC分类号: B01J31/02 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/495 , A61P31/04 , C07B61/00 , C07C307/04 , C07D207/08 , C07D207/12 , C07D207/26 , C07D207/273 , C07D333/20 , C07D401/12 , C07D403/12 , C07D417/06 , C07D477/00 , C07D477/02 , C07D477/14 , C07D477/20 , C07D501/00 , C07D501/04 , C07D501/16 , C07D501/22 , C07D501/46 , C07F7/10 , C07F9/572 , C08L63/00 , C07D487/04
CPC分类号: C07D207/273 , C07C307/04 , C07D207/12 , C07D477/02 , C07D477/14 , C07D477/20 , C07D501/00 , C08L63/00 , Y02P20/55
摘要: A pyrrolidylthiocarbapenem derivative represented by Formula I is provided: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2, R.sup.3 and R.sup.4 are hydrogen, lower alkyl which can be substituted or an amino protecting group independently, or R.sup.2 and R.sup.3 together with a nitrogen atom to which R.sup.2 and R.sup.3 are bonded form a saturated or unsaturated cyclic group, or R.sup.2 and R.sup.4, or R.sup.3 and R.sup.4 together with two nitrogen atoms and one sulfur atom in the sufamide group form a saturated or unsaturated cyclic group; each cyclic group can further include at least one atom selected from the group consisting of oxygen, sulfur and nitrogen, and each cyclic group can be substituted; X.sup.1 is hydrogen or a hydroxy protecting group; X.sup.2 is hydrogen, a carboxy protecting group, an ammonio group, an alkali metal or an alkaline-earth metal; and Y.sup.2 is hydrogen or an amino protecting group.
摘要翻译: 提供由式I表示的吡咯烷基硫代碳青霉烯衍生物:其中R 1是氢或低级烷基; R2,R3和R4是氢,可以被取代的低级烷基或氨基保护基,R2或R3与R2和R3所连接的氮原子一起形成饱和或不饱和的环状基团,或者R 2和R 4, 或R3和R4与磺酰胺基团中的两个氮原子和一个硫原子一起形成饱和或不饱和的环状基团; 每个环状基团可进一步包括至少一个选自氧,硫和氮的原子,并且每个环状基团可被取代; X1是氢或羟基保护基; X2是氢,羧基保护基,铵基,碱金属或碱土金属; 而Y2是氢或氨基保护基。
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公开(公告)号:US4893142A
公开(公告)日:1990-01-09
申请号:US271800
申请日:1988-11-15
CPC分类号: G03B9/14
摘要: A device for activating shutter blades relative to a shutter opening and utilizing a control signal from an electronic circuit includes an electric motor rotatable clockwise and counterclockwise according to a control signal from the electronic circuit, a gear driven by the motor, the gear being located on one side of the shutter opening, fixed pivot axes located on an opposite side of the shutter opening, and a shutter operable device comprising shutter blades pivotable about the fixed pivot axes, the shutter operable device having gear teeth meshing with the gear such that the gear is operable to pivot the shutter blades clockwise and counterclockwise about fixed pivot axes to open and close the shutter opening.
摘要翻译: 用于激活快门叶片相对于快门开口并利用来自电子电路的控制信号的装置包括根据来自电子电路的控制信号顺时针和逆时针旋转的电动机,由电动机驱动的齿轮,齿轮位于 闸门开口的一侧,位于闸门开口相对侧的固定枢转轴线,以及包括围绕固定枢转轴线枢转的闸门叶片的快门可操作装置,所述挡板可操作装置具有与齿轮啮合的齿轮齿,使得齿轮 可操作以围绕固定的枢转轴线顺时针和逆时针枢转快门叶片以打开和关闭快门开口。
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公开(公告)号:US4705852A
公开(公告)日:1987-11-10
申请号:US876976
申请日:1986-06-20
申请人: Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
发明人: Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/57 , C07D505/00 , C07D205/08 , A61K31/535
CPC分类号: C07D505/00 , Y02P20/55
摘要: An antibacterial cephalosporin hydroxamic acid derivative represented by the following formula (I), processes for its preparation, compositions containing the same as an active ingredient, and a method for killing bacteria by contacting with said compound. ##STR1## (wherein, R is acyl; R.sup.1 is hydrogen or methoxy; R.sup.2 is alkylene; R.sup.3 is hydrogen, aliphatic group or a hydroxy-protecting group; R.sup.4 is hydrogen or amino-protecting group; R.sup.5 is hydrogen, light metal atom or carboxy-protecting group; and X is oxygen, sulfur, or sulfinyl).
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公开(公告)号:US4614797A
公开(公告)日:1986-09-30
申请号:US576404
申请日:1984-02-02
申请人: Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
发明人: Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/57 , C07D505/00
CPC分类号: C07D505/00 , Y02P20/55
摘要: An antibacterial cephalosporin hydroxamic acid derivative represented by the following formula (I), processes for its preparation, compositions containing the same as an active ingredient, and a method for killing bacteria by contacting with said compound. ##STR1## (wherein, R is acyl; R.sup.1 is hydrogen or methoxy; R.sup.2 is alkylene; R.sup.3 is hydrogen, aliphatic group or a hydroxy-protecting group; R.sup.4 is hydrogen or amino-protecting group; R.sup.5 is hydrogen, light metal atom or carboxy-protecting group; and X is oxygen, sulfur, or sulfinyl).
摘要翻译: 由下式(I)表示的抗菌头孢菌素异羟肟酸衍生物,其制备方法,含有该活性成分的组合物,以及通过与所述化合物接触来杀死细菌的方法。 (I)(I)(其中R为酰基; R 1为氢或甲氧基; R 2为亚烷基; R 3为氢,脂族基或羟基保护基; R 4为氢或氨基保护基; R 5为氢, 金属原子或羧基保护基; X是氧,硫或亚磺酰基)。
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公开(公告)号:US09334289B2
公开(公告)日:2016-05-10
申请号:US14113459
申请日:2012-04-25
申请人: Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki Sano
发明人: Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki Sano
IPC分类号: C07D501/16 , C07D501/60 , C07D501/18 , C07D501/46 , C07D519/06 , C07D519/00
CPC分类号: C07D501/60 , C07D501/18 , C07D501/46 , C07D519/00 , C07D519/06
摘要: The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
摘要翻译: 本发明提供了具有广谱抗菌谱的新型化合物,并且特别表现出对产生β-内酰胺酶的革兰氏阴性菌具有强效的抗微生物活性。 具体而言,本发明提供了式(I)化合物:其中各符号如说明书中所定义,或氨基保护的化合物,当氨基存在于7-侧链的环上时,或药学上 可接受的盐,以及包含其的药物组合物。
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