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公开(公告)号：US10006076B2
公开(公告)日：2018-06-26
申请号：US14113354
申请日：2011-07-29
CPC分类号： C12Q1/04 , G01N21/77 , G01N33/6851 , G01N2021/7786 , G01N2800/26
摘要： The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins. The dissolution of the human particles also releases the microbes nesting in macrophages. The cultivation in an optically clear nutrient broth with optimum composition not only accelerates the propagation of the microbes compared to all other cultivation methods, but also makes it possible to continuously measure their quantitative growth starting from a low microbe density. This firstly allows the mass spectrometric identification to be carried out at the earliest possible time, secondly provides a positive detection of microbes far ahead of their identification, which can be lifesaving for the patient; and thirdly makes it possible to start the determination of resistances early.
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2.发明授权公开(公告)号：US07386173B1
公开(公告)日：2008-06-10
申请号：US10649340
申请日：2003-08-27
CPC分类号： G06K9/0053 , H01J49/0036
摘要： The present invention relates to graphic presentations of complex analytical data strings containing each a multitude of substance-representing peaks (e.g. mass spectra or chromatograms) and pattern recognition or classification techniques in collections of such data strings. The invention proposes to highlight, after execution of the pattern recognition or classification algorithms, the significantly participating peaks in the graphical display so that the nature of these peaks, and the substances represented by these peaks, can easily be further investigated. The content of the graphical display, particularly the peaks, can be interactively accessed by the user and by the pattern recognition programs.
摘要翻译： 本发明涉及在这种数据串的集合中包含各种物质代表峰（例如质谱或色谱图）和模式识别或分类技术的复杂分析数据串的图形呈现。 本发明提出，在执行图案识别或分类算法之后，在图形显示中强调显着参与的峰值，使得可以容易地进一步研究这些峰值的性质以及由这些峰值表示的物质。 图形显示的内容，特别是峰值可以由用户和模式识别程序交互访问。
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3.发明授权Method for recognizing overload situations in subscriber line modules of a communication system 失效识别通信系统的用户线路模块中的过载情况的方法
公开(公告)号：US5964840A
公开(公告)日：1999-10-12
申请号：US715913
申请日：1996-09-19
申请人： Peter Stevens , Wolfgang Pusch
发明人： Peter Stevens , Wolfgang Pusch
CPC分类号： H04Q11/0428 , H04Q2213/13096 , H04Q2213/13103 , H04Q2213/13106 , H04Q2213/13164 , H04Q2213/13166 , H04Q2213/13176 , H04Q2213/13204 , H04Q2213/1332
摘要： The workloads (Z, ZS, ZS(X), gn1) of a microprocessor system (MPS), of all signaling channels (D) to the connected communication terminal equipment units (KE) and of a memory element pool (SEP) are measured in subscriber line modules (SLMO) of a communication system (KS). The measured workloads are compared to predetermined workload limits (GZ, GZS, gzn1), and an overload of a subscriber line module (SLMO) is recognized dependent on the comparison results. Designational or summary, fast-acting countermeasures can be initiated on the basis of the early recognition of at least two overloads.
摘要翻译： 测量到连接的通信终端设备单元（KE）和存储元件池（SEP）的所有信令信道（D）的微处理器系统（MPS）的工作负载（Z，ZS，ZS（X），gn1） 在通信系统（KS）的用户线路模块（SLMO）中。 将测量的工作负载与预定的工作负载限制（GZ，GZS，gzn1）进行比较，并根据比较结果识别用户线路模块（SLMO）的过载。 可以在早期识别至少两次超载的基础上启动指定或总结，快速反应措施。
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公开(公告)号：US20160251694A1
公开(公告)日：2016-09-01
申请号：US14113354
申请日：2011-07-29
CPC分类号： C12Q1/04 , G01N21/77 , G01N33/6851 , G01N2021/7786 , G01N2800/26
摘要： The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins. The dissolution of the human particles also releases the microbes nesting in macrophages. The cultivation in an optically clear nutrient broth with optimum composition not only accelerates the propagation of the microbes compared to all other cultivation methods, but also makes it possible to continuously measure their quantitative growth starting from a low microbe density. This firstly allows the mass spectrometric identification to be carried out at the earliest possible time, secondly provides a positive detection of microbes far ahead of their identification, which can be lifesaving for the patient; and thirdly makes it possible to start the determination of resistances early.
摘要翻译： 本发明涉及快速检测和快速质谱鉴定血液或其他体液中微生物感染因子的方法和仪器。 本发明认识到，血液不是培养微生物的良好环境，并且提供了（a）在体内流体中大量地破坏或溶解血液中的红细胞和白细胞的方法，而不会损害微生物的能力 （b）将微生物病原体与流体分离，（c）将其培养在不含体液抗微生物成分的营养肉汤中，（d）将其与营养液分离，以及（e） 微生物通过微生物蛋白质的质谱。 人类颗粒的溶解也释放出嵌入巨噬细胞的微生物。 在具有最佳组成的光学透明营养肉汤中培养不仅加速微生物与所有其他培养方法相比的繁殖，而且可以从低微生物密度开始连续测量其定量生长。 这首先允许在早期进行质谱鉴定，其次提供远远超过其鉴定的微生物的阳性检测，这可以为患者挽救; 第三，可以提前开始确定电阻。
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5.发明授权Method for synchronization of base stations which are coupled to different switching system parts in a mobile radio network 有权用于在移动无线电网络中耦合到不同交换系统部分的基站的同步方法公开(公告)号：US06788947B2
公开(公告)日：2004-09-07
申请号：US09998918
申请日：2001-12-03
IPC分类号： H04B701
CPC分类号： H04B7/2687
摘要： A first base station, which is coupled to a first switching system part is set up within radio range of a second base station, which is coupled to a second switching system part. After initial synchronization of the first base station to the first switching system part and of the second base station to the second switching system part, the second base station receives radio frames transmitted from the first base station and determines their time error with respect to its own radio frame clock. The determined time error is then transmitted to the second switching system part. In response to this, the second switching system part transmits a synchronization signal to the second base station, with the transmission time being chosen as a function of the transmitted time error such that the radio frame clock of the second base station is synchronized with the radio frames of the first base station by time alignment with the synchronization signal.
摘要翻译： 耦合到第一交换系统部分的第一基站被建立在第二基站的无线电范围内，第二基站耦合到第二交换系统部分。 在第一基站到第一交换系统部分和第二基站到第二交换系统部分的初始同步之后，第二基站接收从第一基站发送的无线电帧，并且确定它们相对于其自身的时间误差 无线电帧时钟。 所确定的时间误差然后被传送到第二交换系统部分。 响应于此，第二交换系统部分向第二基站发送同步信号，其中传输时间被选择为传输的时间误差的函数，使得第二基站的无线电帧时钟与无线电同步 通过与同步信号的时间对准，第一基站的帧。
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