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公开(公告)号：US06254850B1
公开(公告)日：2001-07-03
申请号：US09480153
申请日：2000-01-10
申请人： Werner Krause , Franz-Karl Maier , Michael Bauer , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschik
发明人： Werner Krause , Franz-Karl Maier , Michael Bauer , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschik
IPC分类号： A61K5104
CPC分类号： A61K49/06 , C07C229/16 , C07C229/36 , C07C233/63 , C07C233/83 , C07C237/06
摘要： The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.
摘要翻译： 本发明涉及含有原子序数20-32,39-51或57-83的元素的二亚乙基三胺五乙酸衍生物及其络合物和络合盐，含有这些化合物的药剂，它们作为对照介质和解毒剂的用途及其生产方法 。
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2.发明授权Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them 失效含有5或6元环的大环多氮化合物，其制备方法和含有它们的药物介质
公开(公告)号：US5403572A
公开(公告)日：1995-04-04
申请号：US213431
申请日：1994-03-15
申请人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
发明人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
IPC分类号： A61K49/06 , A61K51/04 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07F5/00 , A61B5/055 , C07D267/22
CPC分类号： C07F5/003 , A61K49/06 , A61K51/04 , A61K51/0482 , C07D255/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
摘要翻译： 下文定义的下式I和IV的大环化合物及其与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的诊断和治疗剂。
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3.发明授权Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy 失效适用于诊断和治疗的DTPA衍生物的金属络合物
公开(公告)号：US6040432A
公开(公告)日：2000-03-21
申请号：US488287
申请日：1995-06-07
申请人： Werner Krause , Franz-Karl Maier , Michael Bauer , Gabriele Schuhmann Giampieri , Wolf-Rudiger Press , Peter Muschik
发明人： Werner Krause , Franz-Karl Maier , Michael Bauer , Gabriele Schuhmann Giampieri , Wolf-Rudiger Press , Peter Muschik
IPC分类号： A61K49/00 , A61K31/215 , A61K31/28 , A61K31/29 , A61K31/315 , A61K49/06 , A61K51/00 , A61P1/16 , C07C229/16 , C07C229/24 , C07C229/34 , C07C229/36 , C07C229/76 , C07C231/02 , C07C233/63 , C07C233/83 , C07C237/06 , C07F5/00 , A61K51/04 , C07C229/00 , C07F13/00
CPC分类号： A61K49/06 , C07C229/16 , C07C229/36 , C07C233/63 , C07C233/83 , C07C237/06
摘要： The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.
摘要翻译： 本发明涉及含有原子序数20-32,39-51或57-83的元素的二亚乙基三胺五乙酸衍生物及其络合物和络合盐，含有这些化合物的药剂，它们作为对照介质和解毒剂的用途及其生产方法 。
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4.发明授权Macrocyclic compounds as complexing compounds or agents, complexes of metal ions therewith and use thereof as contrast media for diagnostics and therapeutics 失效作为络合化合物或试剂的大环化合物，其金属离子的络合物及其作为诊断和治疗的造影剂的用途
公开(公告)号：US5871709A
公开(公告)日：1999-02-16
申请号：US179552
申请日：1994-01-10
IPC分类号： A61K49/00 , A61K31/395 , A61K49/04 , A61K51/00 , C07D257/02 , C07D303/27 , A61K51/04 , A61B5/055 , C07D225/00 , C07F5/00
CPC分类号： C07D257/02 , Y10S514/836 , Y10T436/24
摘要： Tetraazacyclododecane compounds of general formula I ##STR1## in which E and Q are defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable pharmaceutical agents.
摘要翻译： E和Q定义的通式I（I）的四氮杂环十二烷化合物及其与无机和/或有机碱，氨基酸或氨基酰胺的盐是有价值的药物。
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5.发明授权DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy 失效DTPA衍生物以新颖的方式取代，其金属络合物及其在诊断和治疗中的应用
公开(公告)号：US5746995A
公开(公告)日：1998-05-05
申请号：US565025
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds and their use as contrast media and antidotes.
摘要翻译： 本发明涉及含有原子序数20-32,39-51或57-83的元素的新的二亚乙基三胺五乙酸衍生物，其络合物和络合盐，含有这些化合物的药物及其作为造影介质和解毒剂的用途。
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公开(公告)号：US5980864A
公开(公告)日：1999-11-09
申请号：US671041
申请日：1991-03-19
申请人： Johannes Platzek , Heinz Gries , Hanns-Joachim Weinmann , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press
发明人： Johannes Platzek , Heinz Gries , Hanns-Joachim Weinmann , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press
CPC分类号： C07D257/02 , A61K49/06 , A61K49/106 , A61K51/0482 , Y10S514/836
摘要： 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula I.sub.A ##STR1## in which R.sup.1 means hydrogen or a metal ion equivalent independent of one another andR.sup.2 means a butyltriol radicalas well as their salts with organic or inorganic bases or amino acids are valuable pharmaceutical agents.
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公开(公告)号：US5756066A
公开(公告)日：1998-05-26
申请号：US487096
申请日：1995-06-07
申请人： Danute Nitecki , Werner Krause , Franz-Karl Maier , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschick , Sara Biancalana
发明人： Danute Nitecki , Werner Krause , Franz-Karl Maier , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschick , Sara Biancalana
CPC分类号： A61K49/0442 , C07K14/001 , A61K38/00
摘要： Iodine-containing peptides of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, a, m and q have the meanings indicated in the description, agents containing these compounds, the use of compounds as contrast media as well as processes for their production are described.
摘要翻译： 其中R1，R2，R3，R4，a，m和q具有说明书中所示含义的含有I的通式I（I）的肽，含有这些化合物的试剂，化合物作为造影剂的使用 以及其生产过程。
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8.发明授权
公开(公告)号：US5672335A
公开(公告)日：1997-09-30
申请号：US487094
申请日：1995-06-06
申请人： Werner Krause , Thomas Balzer , Wolf-Rudiger Press , Gabriele Schuhmann-Giampieri , Ulrich Speck , Andreas Muhler
发明人： Werner Krause , Thomas Balzer , Wolf-Rudiger Press , Gabriele Schuhmann-Giampieri , Ulrich Speck , Andreas Muhler
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer tomography of the liver and the biliary tracts.
摘要翻译： 含有原子序数39-42,44-51或56-83的金属和络合剂的金属络合物可用于生产用于肝脏和胆道的对比度增强计算机断层摄影术的造影剂。
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9.发明申请1,4,7,10-Tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them 审中-公开1,4,7,10-四氮杂环十二烷丁基三醇，其制备方法和含有它们的药剂公开(公告)号：US20060078503A1
公开(公告)日：2006-04-13
申请号：US11234385
申请日：2005-09-26
申请人： Johannes Platzek , Heinz Gries , Hanns-Joachim Weinmann , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press
发明人： Johannes Platzek , Heinz Gries , Hanns-Joachim Weinmann , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press
IPC分类号： A61K49/12
CPC分类号： C07D257/02 , A61K49/06 , A61K49/106 , A61K51/0482 , Y10S514/836
摘要： 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula IA in which R1 means hydrogen or a metal ion equivalent independent of one another and R2 means a butyltriol radical as well as their salts with organic or inorganic bases or amino acids are valuable pharmaceutical agents.
摘要翻译： 通式I的1,4,7,10-四氮杂环十二烷基丁醇三醇其中R 1表示氢或彼此独立的R 2的金属离子，R 2 是指丁基三醇基团以及它们与有机或无机碱或氨基酸的盐是有价值的药剂。
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10.发明授权Use of tetra azacycle complexes as x-ray diagnostic agents for the liver and gallbladder 失效使用四氮基复合物作为肝和胆囊的X射线诊断剂
公开(公告)号：US5853699A
公开(公告)日：1998-12-29
申请号：US565397
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The disclosed metal complexes are suitable as contrast media for computer tomography of the liver and the biliary tracts.
摘要翻译： 所公开的金属络合物适合作为肝脏和胆道的计算机断层摄影的造影剂。
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