公开(公告)号：US860474A

公开(公告)日：1907-07-16

申请号：US1906308328

申请日：1906-03-27

Applicant: HOOD GEORGE TURNBULL ,  COCHRANE WILLIAM MURDOCH

Inventor： HOOD GEORGE TURNBULL ,  COCHRANE WILLIAM MURDOCH

CPC classification number: B01F11/0014 ,  Y10S366/602

公开(公告)号：US20120003177A1

公开(公告)日：2012-01-05

申请号：US13119454

申请日：2009-09-17

Applicant: Youqing Shen ,  Huadong Tang ,  Edward Van Kirk ,  William Murdoch ,  Maciej Radosz

Inventor： Youqing Shen ,  Huadong Tang ,  Edward Van Kirk ,  William Murdoch ,  Maciej Radosz

IPC: A61K31/775 ,  C08F212/14 ,  C07C49/205 ,  A61K31/12 ,  A61P35/00 ,  A61K31/704 ,  A61K38/14 ,  A61K33/24 ,  A61K31/337 ,  C08G8/26 ,  A61K31/437

CPC classification number: A61K31/335 ,  A61K9/1273 ,  A61K9/5146 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/605

Abstract: Curcumin, a polyphenol extracted from the rhizome turmeric, has been polymerized to produce a polymer material having a backbone of one or more repeating structural units, at least one of which comprises a curcumin monomer residue. These curcumin-containing polymers have a wide range of pharmacological activities, including, among others antitumor, antioxidant, antiinflammatory, antithrombotic and antibacterial activities. Certain species of these polymers have exhibited remarkable antitumor activity. Water-soluble curcumin derivatives and their use as prodrugs and prodrug carriers are also disclosed.

Abstract translation: 姜黄素是从根茎姜黄提取的多酚，已经被聚合以产生具有一个或多个重复结构单元的主链的聚合物材料，其中至少一个包含姜黄素单体残基。 这些含姜黄素的聚合物具有广泛的药理活性，包括抗肿瘤，抗氧化，抗炎，抗血栓和抗菌活性等。 这些聚合物的某些物质已经表现出显着的抗肿瘤活性。 还公开了水溶性姜黄素衍生物及其作为前药和前药载体的用途。

公开(公告)号：US20070224164A1

公开(公告)日：2007-09-27

申请号：US11599531

申请日：2006-11-14

Applicant: Maciej Radosz ,  Youqing Shen ,  Edward VanKirk ,  William Murdoch

Inventor： Maciej Radosz ,  Youqing Shen ,  Edward VanKirk ,  William Murdoch

IPC: A61K31/765 ,  C08F20/00

CPC classification number: C08F267/06 ,  A61K33/24 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6903 ,  A61K47/6929 ,  A61K47/6935 ,  A61K49/128 ,  A61K49/1803 ,  B82Y5/00

Abstract: A nano-sized hydrogel is made of a water-soluble chain containing carboxylic acid moieties and polyethylene side chains. Such a nanogel is applicable as a cancer-drug delivery agent or an imagining agent, where either a cancer drug, such as cisplatin, or an imaging agent, such as Gd3+. The complexation of the cancer drug or the imaging agent with the carboxyl moieties leads to the hydrogel formation.

Abstract translation: 纳米尺寸的水凝胶由含有羧酸部分和聚乙烯侧链的水溶性链制成。 这样的纳米凝胶可用作癌症药物递送剂或想象剂，其中癌症药物如顺铂或成像剂如Gd 3+。 癌症药物或成像剂与羧基部分的复合导致水凝胶形成。

公开(公告)号：US20060251547A1

公开(公告)日：2006-11-09

申请号：US11122965

申请日：2005-05-05

Applicant: Larry Windes ,  William Murdoch ,  Thomas Yount ,  Paul Scherrer ,  Richard Bonner ,  Christopher Slaughter

Inventor： Larry Windes ,  William Murdoch ,  Thomas Yount ,  Paul Scherrer ,  Richard Bonner ,  Christopher Slaughter

IPC: B01J19/00

CPC classification number: B01J19/247 ,  B01J10/02 ,  B01J19/006 ,  B01J19/32 ,  B01J19/325 ,  B01J2219/00768 ,  B01J2219/32206 ,  B01J2219/32213 ,  B01J2219/32227 ,  B01J2219/32237 ,  B01J2219/32255 ,  B01J2219/32272 ,  B01J2219/32275 ,  B01J2219/32286 ,  B01J2219/32289 ,  B01J2219/32408 ,  B01J2219/32416 ,  B01J2219/32491 ,  C08G63/785

Abstract: A bundle assembly for vertical, gravity flow driven polymerization reactors for combinations of high viscosity, high throughput, and thin polymer films is provided. The bundle assembly includes static internal components that provide large areas of free liquid surfaces in contact with the atmosphere of the reactor while still attaining sufficient liquid holdup times for polymerization to take place. The bundle assembly includes one or more stationary film generators. The bundle assembly further includes one or more stationary arrays of film support structures. Each of the film support structures has a first side and a second side. Both sides of the film support structure are coated with flowing polymer. The vertical arrangement of components in the bundle assembly cause the polymeric melt to cascade down the vertical length of a reaction vessel interior that incorporates the bundle assembly. The present invention also provides a polymerization reactor that incorporates the assembly of the invention and a method of increasing the degree of polymerization of a polymer melt by using the assembly of the invention.

Abstract translation: 提供了用于高粘度，高通量和薄聚合物膜的组合的垂直重力流驱动聚合反应器的束组件。 束组件包括静态内部部件，其提供与反应器的气氛接触的大面积的游离液体表面，同时仍然获得足够的液体滞留时间以进行聚合。 束组件包括一个或多个固定膜发生器。 束组件还包括一个或多个静止的膜支撑结构阵列。 每个膜支撑结构具有第一侧和第二侧。 薄膜支撑结构的两侧涂有流动的聚合物。 束组件中的部件的垂直布置使得聚合物熔体沿着并入束组件的反应容器内部的垂直长度逐渐下降。 本发明还提供一种聚合反应器，其包含本发明的组合物和通过使用本发明的组合物提高聚合物熔体的聚合度的方法。