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    Software performance profiling in a multi-tenant environment
    1.
    发明授权
    Software performance profiling in a multi-tenant environment 有权
    软件性能分析在多租户环境中

    公开(公告)号：US08839209B2

    公开(公告)日：2014-09-16

    申请号：US13033566

    申请日：2011-02-23

    申请人： William Gallagher ,  Zuye Zheng ,  Fiaz Hossain ,  James Iry ,  Nagraj Kulkarni

    发明人： William Gallagher ,  Zuye Zheng ,  Fiaz Hossain ,  James Iry ,  Nagraj Kulkarni

    IPC分类号： G06F9/44

    CPC分类号： G06F9/44 ,  G06F11/3409 ,  G06F11/3495 ,  G06F11/3612 ,  G06F2201/815 ,  G06F2201/865

    摘要： A method for software performance analysis and debugging in a multi-tenant database network system is provided. In at least one embodiment, sampling is achieved using configuration files of each server cluster. Knowledge of the host names of each server in the cluster enables a profiler to target a single server for each sample, thereby facilitating a round-robin sample across a clustered server environment such that a CPU's load and processing cost associated to sampling is fairly and uniformly distributed across all servers in the cluster. As a result, in at least one embodiment of the analysis and debugging tool each sample is a complete stack trace dump of each thread running on the application server at that moment in time.

    摘要翻译： 提供了一种在多租户数据库网络系统中进行软件性能分析和调试的方法。 在至少一个实施例中，使用每个服务器集群的配置文件来实现采样。 了解集群中每个服务器的主机名称使分析器能够针对每个样本的单个服务器，从而有助于跨群集服务器环境的循环抽样，使得与采样相关联的CPU的负载和处理成本相当均匀 分布在群集中的所有服务器上。 因此，在分析和调试工具的至少一个实施例中，每个样本是在该时刻在应用服务器上运行的每个线程的完整堆栈跟踪转储。

    Method and system for image analysis
    3.
    发明授权
    Method and system for image analysis 有权
    图像分析方法与系统

    公开(公告)号：US08116551B2

    公开(公告)日：2012-02-14

    申请号：US12746165

    申请日：2008-12-04

    申请人： William Gallagher ,  Elton Rexhepaj ,  Donal Brennan

    发明人： William Gallagher ,  Elton Rexhepaj ,  Donal Brennan

    IPC分类号： G06K9/00

    CPC分类号： G06K9/0014 ,  G06F19/20 ,  G06T7/0014 ,  G06T2207/10056 ,  G06T2207/20036 ,  G06T2207/30024

    摘要： The present invention relates generally to a method for determining the level of expression of one or more candidate objects of interest in a biological sample. In particular, the present invention relates to a method for determining the level of expression of one or more candidate objects of interest using image analysis. More specifically, the present invention relates to a method and a system for determining the level of expression of one or more candidate objects of interest using an automated (computer-aided) image analysis system.

    摘要翻译： 本发明一般涉及用于确定生物样品中感兴趣的一个或多个候选物体的表达水平的方法。 特别地，本发明涉及使用图像分析来确定感兴趣的一个或多个候选对象的表达水平的方法。 更具体地，本发明涉及一种使用自动（计算机辅助）图像分析系统来确定感兴趣的一个或多个候选对象的表达水平的方法和系统。

    System and method of managing internet browser navigation
    4.
    发明授权
    System and method of managing internet browser navigation 有权
    管理互联网浏览器导航的系统和方法

    公开(公告)号：US07945550B1

    公开(公告)日：2011-05-17

    申请号：US12498056

    申请日：2009-07-06

    申请人： Jeffrey William Gallagher ,  Randal Lane Schnedler

    发明人： Jeffrey William Gallagher ,  Randal Lane Schnedler

    IPC分类号： G06F7/00

    CPC分类号： G06F17/30861 ,  G06F3/0481 ,  G06F17/30867 ,  G06F17/30896 ,  G06F17/30899 ,  Y10S707/99931

    摘要： The present invention provides a system and method of managing Internet browser navigation. Software code designed to interact with and control the user's Internet browser is embedded into web pages made available to remote users by a web server. Embedded software code is read by the user's Internet browser upon loading a requested web page. Embedded software code directs the browser to store one or more attributes upon the remote user's computer system. Stored attributes may then be compared to attributes embedded within subsequently requested web pages to determine if the requested web page, or a corrected web page, should be displayed.

    摘要翻译： 本发明提供一种管理因特网浏览器导航的系统和方法。 旨在与用户互联网浏览器进行交互和控制的软件代码嵌入到Web服务器为远程用户提供的网页中。 嵌入式软件代码在加载请求的网页时由用户的Internet浏览器读取。 嵌入式软件代码指示浏览器将一个或多个属性存储在远程用户的计算机系统上。 然后可以将存储的属性与嵌入随后请求的网页中的属性进行比较，以确定是否应显示所请求的网页或修正的网页。

    Wheelhouse Inner Bracket for Automotive Vehicles
    5.
    发明申请
    Wheelhouse Inner Bracket for Automotive Vehicles 有权
    汽车车轮内置支架

    公开(公告)号：US20100133879A1

    公开(公告)日：2010-06-03

    申请号：US12324944

    申请日：2008-11-28

    申请人： Philip John Leonetti ,  Ron Allen Carpenter ,  Steve William Gallagher

    发明人： Philip John Leonetti ,  Ron Allen Carpenter ,  Steve William Gallagher

    IPC分类号： B62D27/02 ,  B62D25/00 ,  B60R99/00

    CPC分类号： B62D25/088 ,  B62D25/16 ,  B62D25/2027

    摘要： A wheelhouse reinforcement bracket is provided for the rear wheelhouses of an automotive vehicle to increase torsional rigidity for the vehicle. The wheelhouse bracket is positioned in alignment with the location on the vehicle body where the shock absorber is located, and in alignment with the rear suspension cross member to create a structural ring formed by the wheelhouse bracket, the C-pillar and the rear suspension cross member. The wheelhouse bracket is formed with a mounting flange positionable within the inside of the U-shaped rear side rail to facilitate welding thereto instead of being welded to the top of the underbody floor structure. The mounting flange has a first portion configured to be mated against a first generally vertically extending wall of the rear side rail and a second portion configured to be mated against a generally horizontally extending wall of the rear side rail.

    摘要翻译： 为汽车的后轮车厢提供驾驶室加强支架，以增加车辆的扭转刚性。 驾驶室支架定位成与减震器所在车体上的位置对准，并与后悬架横梁对准，以产生由驾驶室支架，C柱和后悬架十字架形成的结构环 会员。 驾驶室支架形成有可定位在U形后侧轨道内侧的安装凸缘，以便于焊接而不是焊接到底部底板结构的顶部。 安装凸缘具有第一部分，该第一部分构造成与后侧导轨的第一大致垂直延伸的壁相配合;以及第二部分，其构造成与后侧导轨的大致水平延伸的壁配合。

    Markers for melanoma
    6.
    发明申请
    Markers for melanoma 审中-公开
    黑色素瘤标记物

    公开(公告)号：US20090093424A1

    公开(公告)日：2009-04-09

    申请号：US11713088

    申请日：2007-03-02

    申请人： William Gallagher ,  Mairin Rafferty ,  William Faller

    发明人： William Gallagher ,  Mairin Rafferty ,  William Faller

    IPC分类号： A61K31/7088 ,  C12Q1/68 ,  C40B40/08 ,  A61P35/00

    CPC分类号： A61K31/7088 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158

    摘要： A method of diagnosing melanoma and/or monitoring melanoma progression, in particular for determining whether the melanoma is likely to have metastatic capabilities, in a subject includes the steps of in a test sample determining the methylation status of FABP5 wherein methylation of the gene indicates a positive diagnosis of melanoma and/or increased methylation of the gene indicates the progression of melanoma. Methods of monitoring melanoma progression may also incorporate measuring the expression levels of FABP5, with low levels of expression indicating a positive diagnosis of melanoma and/or lower levels of expression being indicative of progression of melanoma. Methods of treating melanoma in a subject comprise administering a therapeutically effective amount of a DNA methyltransferase inhibitor or a histone deacetylase inhibitor to the subject such that expression of FABP5 is increased. Microarrays for use in these diagnostic methods and compound screening methods based around monitoring methylation and/or expression of FABP5 are also envisaged.

    摘要翻译： 在受试者中诊断黑素瘤和/或监测黑素瘤进展的方法，特别是用于确定黑素瘤是否可能具有转移能力的方法包括测定样品中测定FABP5的甲基化状态的步骤，其中该基因的甲基化表示 黑素瘤的阳性诊断和/或基因的甲基化增加表明黑色素瘤的进展。 监测黑素瘤进展的方法还可以包括测量FABP5的表达水平，低水平的表达指示黑色素瘤的阳性诊断和/或指示黑色素瘤进展的较低水平的表达。 在受试者中治疗黑素瘤的方法包括向受试者施用治疗有效量的DNA甲基转移酶抑制剂或组蛋白脱乙酰酶抑制剂，使得FABP5的表达增加。 还设想了用于这些诊断方法的微阵列和基于监测FABP5的甲基化和/或表达的复合筛选方法。

    Compounds useful as photodynamic therapeutic agents
    7.
    发明授权
    Compounds useful as photodynamic therapeutic agents 有权
    可用作光动力治疗剂的化合物

    公开(公告)号：US07220732B2

    公开(公告)日：2007-05-22

    申请号：US10508754

    申请日：2003-03-24

    申请人： Donal O'Shea ,  John Killoran ,  William Gallagher

    发明人： Donal O'Shea ,  John Killoran ,  William Gallagher

    IPC分类号： A61K31/69 ,  A61K31/53 ,  C07D251/72

    CPC分类号： C07F5/022

    摘要： The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent; R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: H; a substituted or unsubstituted, saturated or unsaturated, cyclic, moiety; a substituted or unsubstituted, saturated or unsaturated, heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl or acyl moiety; and R2and R5 may also be independently a heavy atom or a water-solubilizing group. The present invention also relates to use of these compounds in the therapy in vivo or in vitro of a photosensitive target biological cell by irradiation, as well as methods of treating a photosensitive target biological cell in vivo or in vitro. Finally, the present invention relates to pharmaceutical compositions, comprising these compounds, in association with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 本发明涉及下式的化合物或其盐，金属配合物或水合物或其它溶剂化物，其中：M为螯合剂; R 1，R 2，R 3，R 4，R 5和R 5， R 6独立地选自：H; 取代或未取代的饱和或不饱和的环状部分; 取代或未取代的饱和或不饱和的杂环部分; 或取代或未取代的饱和或不饱和的直链或支链烷基或酰基部分; R 2和R 5也可以独立地是重原子或水溶性基团。 本发明还涉及这些化合物在体内或体外通过照射进行光敏靶生物细胞治疗的用途，以及在体内或体外治疗感光性靶生物细胞的方法。 最后，本发明涉及与药学上可接受的稀释剂或载体结合的包含这些化合物的药物组合物。

    System and method for scheduling disk writes in an application server or transactional environment
    8.
    发明申请
    System and method for scheduling disk writes in an application server or transactional environment 有权
    在应用程序服务器或事务环境中调度磁盘写入的系统和方法

    公开(公告)号：US20070005882A1

    公开(公告)日：2007-01-04

    申请号：US11343979

    申请日：2006-01-30

    申请人： William Gallagher ,  Dean Jacobs ,  Anno Langen

    发明人： William Gallagher ,  Dean Jacobs ,  Anno Langen

    IPC分类号： G06F12/00

    CPC分类号： G06F3/0659 ,  G06F3/0607 ,  G06F3/0613 ,  G06F3/0676 ,  Y10S707/99953

    摘要： A system and a method for scheduling disk writes for use with an application server, transactional system, or other server. The disk scheduler and method is independent of the underlying operating system and the disk hardware. This allows it to be used without porting to the various settings in which application server might be deployed. In some embodiments, a high-performance, transactional filestore is also provided to minimize the latency of small, synchronous writes to disk. The implementation uses a log-structured file system combined with disk scheduling. By relaxing the requirement that log records be physically contiguous, every modification to the disk can be scheduled.

    摘要翻译： 用于调度磁盘写入以与应用服务器，事务系统或其他服务器一起使用的系统和方法。 磁盘调度程序和方法独立于底层操作系统和磁盘硬件。 这样可以使用它，而不需要移植到可能部署应用程序服务器的各种设置。 在一些实施例中，还提供高性能的事务文件存储以最小化对磁盘的小的同步写入的等待时间。 该实现使用与磁盘调度相结合的日志结构文件系统。 通过放松日志记录在物理上连续的要求，可以对磁盘进行每次修改。

    Methods and systems for providing one code address correction service
    9.
    发明申请
    Methods and systems for providing one code address correction service 有权
    提供一个代码地址校正服务的方法和系统

    公开(公告)号：US20060184269A1

    公开(公告)日：2006-08-17

    申请号：US11225198

    申请日：2005-09-14

    申请人： James Wilson ,  Lisa West ,  Gary Reblin ,  William Gallagher

    发明人： James Wilson ,  Lisa West ,  Gary Reblin ,  William Gallagher

    IPC分类号： G06F7/00

    CPC分类号： B07C3/10 ,  B07C3/14 ,  G07B17/00661 ,  G07B2017/00451 ,  G07B2017/00588 ,  G07B2017/00717

    摘要： One code address correction service. A carrier of items provides a sender of an item an address change service for an undeliverable address. The item includes a human readable address and a machine readable code. The machine readable code identifies at least the sender. The carrier scans the machine readable code to identify the sender and creates an address change record for the sender. The address change record includes the undeliverable address. The carrier then sends the address change record to the sender.

    摘要翻译： 一个代码地址校正服务。 项目的运营商向项目的发送者提供不可递送地址的地址更改服务。 该项目包括人类可读地址和机器可读代码。 机器可读代码至少识别发件人。 运营商扫描机器可读代码以识别发件人，并为发件人创建地址更改记录。 地址更改记录包括无法投递的地址。 运营商然后将地址更改记录发送给发送方。