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    STABILIZATION OF RNA IN INTACT CELLS WITHIN A BLOOD SAMPLE
    2.
    发明申请
    STABILIZATION OF RNA IN INTACT CELLS WITHIN A BLOOD SAMPLE 审中-公开
    在血液样品中的细胞核中RNA的稳定性

    公开(公告)号：US20110111410A1

    公开(公告)日：2011-05-12

    申请号：US12941437

    申请日：2010-11-08

    Applicant: Wayne L. Ryan ,  M. Rohan Fernando

    Inventor： Wayne L. Ryan ,  M. Rohan Fernando

    IPC: C12Q1/68 ,  C12N5/00

    CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/127 ,  C12Q2527/137 ,  C12Q2527/101

    Abstract: A method for preserving and processing nucleic acids located within a blood sample is disclosed, wherein a blood sample containing nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the integrity and amount of cellular nucleic acids that can be identified and tested while avoiding contamination of the isolated nucleic acids with cell-free nucleic acids.

    Abstract translation: 公开了一种用于保存和处理位于血液样品内的核酸的方法，其中处理含有核酸的血液样品以降低血液样品中的血细胞裂解和核酸酶活性。 样品的处理有助于增加可以鉴定和测试的细胞核酸的完整性和量，同时避免用无细胞核酸污染分离的核酸。

    SIMULATED BLOOD COMPONENTS AND METHODS
    3.
    发明申请
    SIMULATED BLOOD COMPONENTS AND METHODS 审中-公开
    模拟血液成分和方法

    公开(公告)号：US20100047905A1

    公开(公告)日：2010-02-25

    申请号：US12606630

    申请日：2009-10-27

    Applicant: Wayne L. Ryan

    Inventor： Wayne L. Ryan

    IPC: C12N5/07

    CPC classification number: G01N33/96 ,  G01N2015/1006 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25

    Abstract: A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells other than human blood cells; a second cellular component including a plurality of a second group of processed animal red blood cells other than human blood cells; a third cellular component including a plurality of a third group of processed animal red blood cells other than human blood cells; wherein one or more of the first second and third cellular components include a nucleus; and the control simulates erythroblasts of a human blood sample on an automated blood analyzer that analyzes blood cells using impedance, optical measurements or both.

    Abstract translation: 用于其中的对照和细胞级分及其制备方法，包括第一种细胞组分，其包含除人血细胞以外的多种第一组加工动物红细胞; 第二细胞组分，包括除人血细胞以外的多个第二组处理的动物红细胞; 第三细胞组分，其包括除人血细胞之外的多个第三组加工动物红细胞; 其中所述第一和第三细胞组分中的一种或多种包括核; 并且该控制在自动化血液分析仪上模拟人血液样品的成红细胞，其使用阻抗，光学测量或两者分析血细胞。

    SIMULATED BLOOD COMPONENTS AND METHODS
    4.
    发明申请
    SIMULATED BLOOD COMPONENTS AND METHODS 失效
    模拟血液成分和方法

    公开(公告)号：US20080254543A1

    公开(公告)日：2008-10-16

    申请号：US12100658

    申请日：2008-04-10

    Applicant: Wayne L. Ryan

    Inventor： Wayne L. Ryan

    IPC: G01N31/00

    CPC classification number: G01N33/96 ,  G01N2015/1006 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25

    Abstract: A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells other than human blood cells; a second cellular component including a plurality of a second group of processed animal red blood cells other than human blood cells; a third cellular component including a plurality of a third group of processed animal red blood cells other than human blood cells; wherein one or more of the first second and third cellular components include a nucleus; and the control simulates erythroblasts of a human blood sample on an automated blood analyzer that analyzes blood cells using impedance, optical measurements or both.

    Abstract translation: 用于其中的对照和细胞级分及其制备方法，包括第一种细胞组分，其包含除人血细胞以外的多种第一组加工动物红细胞; 第二细胞组分，包括除人血细胞以外的多个第二组处理的动物红细胞; 第三细胞组分，其包括除人血细胞之外的多个第三组加工动物红细胞; 其中所述第一和第三细胞组分中的一种或多种包括核; 并且该控制在自动化血液分析仪上模拟人血液样品的成红细胞，其使用阻抗，光学测量或两者分析血细胞。

    Process, composition and kit for providing a stable whole blood calibrator/control
    5.
    发明授权
    Process, composition and kit for providing a stable whole blood calibrator/control 有权
    用于提供稳定的全血校准器/控制的方法，组成和试剂盒

    公开(公告)号：US07390663B2

    公开(公告)日：2008-06-24

    申请号：US11362362

    申请日：2006-02-23

    Applicant: Wayne L. Ryan ,  Bradford A. Hunsley

    Inventor： Wayne L. Ryan ,  Bradford A. Hunsley

    IPC: G01N31/00 ,  G01N33/48

    CPC classification number: C12Q1/54 ,  G01N33/80 ,  Y10T436/10 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2525

    Abstract: The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a glycolyzed red blood cell component which has been treated with a glycolysis stabilizing effective amount of at least one non-crosslinking aldehyde compound which may be added to fresh plasma along with an amount of glucose to form a simulated whole blood glucose control product, effective for maintaining a particular and essentially stable glucose concentration over a period of time sufficient for accurate measurement and calibration of a glucose measuring instrument.

    Abstract translation: 本发明涉及用于在葡萄糖监测仪器中使用的稳定的校准器和/或控制，试剂盒和方法。 原则上，本发明教导了糖酵解的红细胞成分，其已用糖酵解稳定有效量的至少一种非交联醛化合物处理，该化合物可与一定量的葡萄糖一起加入到新鲜血浆中以形成模拟的全血 葡萄糖对照产品，其有效地用于在足以准确测量和校准葡萄糖测量仪器的时间段内维持特定且基本上稳定的葡萄糖浓度。

    Hematology reference control
    6.
    发明授权
    Hematology reference control 有权
    血液学参考控制

    公开(公告)号：US06653137B2

    公开(公告)日：2003-11-25

    申请号：US10007519

    申请日：2001-12-03

    Applicant: Wayne L. Ryan

    Inventor： Wayne L. Ryan

    IPC: G01N3100

    CPC classification number: G01N33/5002 ,  G01N33/96 ,  G01N2015/1006 ,  Y10T436/10 ,  Y10T436/101666

    Abstract: An improved control for a hematology analyzer. In one embodiment, blood cells are treated for permitting the cells to simulate nucleated red blood cells for detection or analysis by the hematology analyzer.

    Abstract translation: 改进的血液分析仪控制。 在一个实施方案中，处理血细胞以允许细胞模拟有核红细胞用于血液分析仪的检测或分析。

    Blood control and system for erythrocyte sedimentation measurement
    9.
    发明授权
    Blood control and system for erythrocyte sedimentation measurement 有权
    血液控制和红细胞沉降测定系统

    公开(公告)号：US6124089A

    公开(公告)日：2000-09-26

    申请号：US324279

    申请日：1999-06-02

    Applicant: Wayne L. Ryan

    Inventor： Wayne L. Ryan

    IPC: G01N33/96 ,  C12Q1/00 ,  C12Q1/24

    CPC classification number: G01N33/96

    Abstract: A control and system for blood testing, including a control having morphologically fixed and stabilized blood cells that have been added to a diluent. The control and system can be used advantageously for indirect acute protein plasma measurement, including erythrocyte sedimentation rate testing.

    Abstract translation: 用于血液测试的对照和系统，包括已经加入到稀释剂中的具有形态上固定和稳定的血细胞的对照。 控制和系统可以有利地用于间接急性蛋白质血浆测量，包括红细胞沉降速率测试。

    White blood cell hematology control
    10.
    发明授权
    White blood cell hematology control 失效
    白细胞血液学控制

    公开(公告)号：US5981282A

    公开(公告)日：1999-11-09

    申请号：US786230

    申请日：1997-01-21

    Applicant: Wayne L. Ryan

    Inventor： Wayne L. Ryan

    IPC: G01N33/92 ,  G01N33/96

    CPC classification number: G01N33/92 ,  G01N33/96 ,  G01N2496/05 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664 ,  Y10T436/107497 ,  Y10T436/108331

    Abstract: Reference controls comprised of aldehyde-fixed white blood cells stabilized red blood cells and simulated blood platelets exhibiting a white blood cell histogram profile that is substantially that of whole blood are obtained by the addition of a lipoprotein to the control and an antioxidant to inhibit lysis of stabilized red blood cells by said lipoprotein.

    Abstract translation: 由醛固定的白细胞组成的参考对照稳定的红细胞和显示基本上是全血的白细胞直方图轮廓的模拟血小板通过向对照添加脂蛋白和抗氧化剂来获得，以抑制裂解 由所述脂蛋白稳定的红细胞。

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