公开(公告)号：US20100196404A1

公开(公告)日：2010-08-05

申请号：US12614109

申请日：2009-11-06

申请人： RAYMOND G. GOODWIN ,  WANWAN S. DIN

发明人： RAYMOND G. GOODWIN ,  WANWAN S. DIN

IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00

CPC分类号： G01N33/6863 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2500/20 ,  Y10S930/14

摘要： The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed.

摘要翻译： 本发明公开了TNF受体（TACI）及其相互作用配体（TACI-L）之间的新型相互作用。 还公开了筛选候选分子以确定TACI / TACI-L相互作用的潜在拮抗剂和激动剂的方法。 还公开了使用拮抗剂和激动剂作为治疗剂来治疗自身免疫性疾病，炎症和抑制移植物与宿主排斥反应。

公开(公告)号：US20090081700A1

公开(公告)日：2009-03-26

申请号：US12220483

申请日：2008-07-23

申请人： Raymond G. Goodwin ,  Wanwan S. Din

发明人： Raymond G. Goodwin ,  Wanwan S. Din

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/6863 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2500/20 ,  Y10S930/14

摘要： The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed.

摘要翻译： 本发明公开了TNF受体（TACI）及其相互作用配体（TACI-L）之间的新型相互作用。 还公开了筛选候选分子以确定TACI / TACI-L相互作用的潜在拮抗剂和激动剂的方法。 还公开了使用拮抗剂和激动剂作为治疗剂来治疗自身免疫性疾病，炎症和抑制移植物与宿主排斥反应。

公开(公告)号：US08133976B2

公开(公告)日：2012-03-13

申请号：US12614109

申请日：2009-11-06

申请人： Raymond G. Goodwin ,  Wanwan S. Din

发明人： Raymond G. Goodwin ,  Wanwan S. Din

IPC分类号： C07K14/525 ,  C07K14/475 ,  C07K14/715

CPC分类号： G01N33/6863 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2500/20 ,  Y10S930/14

摘要： The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed.

摘要翻译： 本发明公开了TNF受体（TACI）及其相互作用配体（TACI-L）之间的新型相互作用。 还公开了筛选候选分子以确定TACI / TACI-L相互作用的潜在拮抗剂和激动剂的方法。 还公开了使用拮抗剂和激动剂作为治疗剂来治疗自身免疫性疾病，炎症和抑制移植物与宿主排斥反应。