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公开(公告)号：US12061147B2
公开(公告)日：2024-08-13
申请号：US17619082
申请日：2020-06-23
发明人： Dominic Zerulla
IPC分类号： G01N21/552 , G01N21/17 , G01N21/64
CPC分类号： G01N21/553 , G01N21/648 , G01N2021/1731
摘要： An imaging apparatus for imaging a sample (7) comprises an array of electronically addressable pixels (6) wherein each pixel is arranged to support a surface plasmon resonance therein to generate an evanescent electromagnetic field. This field extends transversely from the pixel so as to be salient from the array at a first side of the array for illuminating the sample at said first side. A light source (15) is arranged to illuminate the array with excitation light therewith to generate said surface plasmon resonance. An optical detector (12A, 12B, 12C) is arranged at a second side of the array which is opposite to said first side of the array for detecting optical radiation returned from the array in response to illumination of the array by said excitation light. A processing unit (4) is arranged to associate the detected optical radiation with the address of the pixel or pixels within the array at which the surface plasmon resonance was generated.
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公开(公告)号：US20240002947A1
公开(公告)日：2024-01-04
申请号：US18066693
申请日：2022-12-15
申请人： The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin , University College Dublin, National University of Ireland, Dublin
发明人： Adrian Bracken , Fiona Lanigan , William Gallagher
IPC分类号： C12Q1/6886 , G01N33/574 , A61K31/519
CPC分类号： C12Q1/6886 , G01N33/57415 , G01N33/57484 , A61K31/519 , C12Q2600/158 , C12Q2600/118 , C12Q2600/106
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
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公开(公告)号：US11477666B2
公开(公告)日：2022-10-18
申请号：US16486430
申请日：2018-02-15
发明人： Stepan Kucera , Holger Claussen , David Lynch , David Fagan , Michael Fenton , Michael O'Neill
IPC分类号： H04L12/26 , H04W24/02 , G06N3/02 , H04W24/06 , H04W28/02 , H04W52/54 , H04W72/04 , H04W72/12
摘要： In one example embodiment, a method includes obtaining sets of input data and an objective, the sets of input data including values of wireless network communication parameters, generating sets of output data for the sets of input data in accordance with the objective, generating a mapping of the sets of input data to the sets of output data and training a network controller using the mapping.
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公开(公告)号：US20210362105A1
公开(公告)日：2021-11-25
申请号：US17285243
申请日：2019-10-15
IPC分类号： B01F13/00 , B01F3/04 , B01F15/00 , B01F15/06 , B01F3/08 , B01F11/00 , C02F1/22 , C02F3/28 , B01D53/32
摘要： The present disclosure relates to a system, generator and method for generating nanobubbles or nanodroplets and treating a multi-component mixture, and in particular for treating biogas and wastewater. The method comprises using nanobubbles of a gas component, and wastewater, to form hydrates in a treatment vessel; removing residual dirt from the treatment vessel and melting the hydrates to facilitate release of clean water.
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公开(公告)号：US20210101811A1
公开(公告)日：2021-04-08
申请号：US17122446
申请日：2020-12-15
发明人： Eoin CASEY , Eoin SYRON
摘要： The present invention is concerned with a fibre membrane for use in a Membrane Supported Biofilm Reactor (MSBR) or the like, the fibre membrane comprising a substantially cylindrical sidewall defining an internal lumen from which gas can permeate through the sidewall, and characterised in that at least a part of an outer surface of the fibre membrane is engineered to define at least one biofilm retaining region which acts to retain a quantity of biofilm therein, in particular when the fibre membrane is subjected to a high sheer biofilm control event, such as experienced during a reactor cleaning cycle, for removing excess biofilm in order to prevent clogging of the reactor.
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6.发明申请公开(公告)号：US20210062164A1
公开(公告)日：2021-03-04
申请号：US17029629
申请日：2020-09-23
发明人： Kevin O'Connor , Susan Molloy , Reeta Davis , Wesley Shaw
摘要： A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.
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公开(公告)号：US20210054400A1
公开(公告)日：2021-02-25
申请号：US16492679
申请日：2018-03-09
申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN , Agriculture and Food Development Authority (TEAGASC)
摘要： A recombinant construct comprising a nucleotide sequence of SEQUENCE ID NO. 1 or a functional variant or functional fragment thereof is provided. Also provided are plant cells transformed with the gene and plant material, including plant cell cultures, seeds and plants, comprising the transformed plant cells.
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公开(公告)号：US20200157643A1
公开(公告)日：2020-05-21
申请号：US16722041
申请日：2019-12-20
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
发明人： Adrian BRACKEN , Fiona LANIGAN , William GALLAGHER
IPC分类号： C12Q1/6886 , G01N33/574 , A61K31/519
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
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公开(公告)号：US20200008738A1
公开(公告)日：2020-01-09
申请号：US16496078
申请日：2018-03-21
发明人： Frank DILLON , Eoin O'CEARBHAILL , Kevin KRIEGER
IPC分类号： A61B5/00
摘要： An oral appliance (100) comprising a sensing arrangement (101) disposed in proximity to at least one part of a facial muscle complex of a user. A method of controlling the oral appliance (100) comprising sensing, with the sensing arrangement (101), the at least one part of the facial muscle complex being brought towards the sensing arrangement; and in response to sensing the at least one part of the facial muscle complex being brought towards the sensing arrangement (101), controlling the oral appliance (100) to perform an action. An external processing unit (200) is arranged to interact with the oral appliance (100) in response to the oral appliance (100) performing the action.
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公开(公告)号：US20190151238A1
公开(公告)日：2019-05-23
申请号：US16091312
申请日：2017-04-06
发明人： Ulla Knaus
摘要： A delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, for use in a method for the treatment or prevention of inflammatory bowel disease in a mammal, is described. The method comprises a step of orally administering to the mammal the delivery system, wherein the delivery system is formulated for oral delivery and release of the hydrogen peroxide or hydrogen peroxide generator system in-situ at a target location in the mammalian gastrointestinal tract. Also described is an oral dosage delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, in which the delivery system is configured for oral administration to a mammal and release of the hydrogen peroxide or hydrogen peroxide generator system at a target location within the mammalian gastrointestinal tract thereby effecting a localised increase in hydrogen peroxide levels at the target location in the mammalian gut or airways.
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