公开(公告)号：US20190151238A1

公开(公告)日：2019-05-23

申请号：US16091312

申请日：2017-04-06

申请人： University College Dublin, National University of Ireland, Dublin

发明人： Ulla Knaus

IPC分类号： A61K9/00 ,  A61K38/44 ,  A61K33/40 ,  A61K35/74 ,  A61K9/50 ,  A61P1/00

摘要： A delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, for use in a method for the treatment or prevention of inflammatory bowel disease in a mammal, is described. The method comprises a step of orally administering to the mammal the delivery system, wherein the delivery system is formulated for oral delivery and release of the hydrogen peroxide or hydrogen peroxide generator system in-situ at a target location in the mammalian gastrointestinal tract. Also described is an oral dosage delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, in which the delivery system is configured for oral administration to a mammal and release of the hydrogen peroxide or hydrogen peroxide generator system at a target location within the mammalian gastrointestinal tract thereby effecting a localised increase in hydrogen peroxide levels at the target location in the mammalian gut or airways.