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公开(公告)号：US06613331B1
公开(公告)日：2003-09-02
申请号：US09413858
申请日：1999-10-07
IPC分类号： A61K3902
CPC分类号： C12N1/20 , A61K38/00 , A61K39/00 , C07K14/20 , C07K16/1207 , Y02A50/401
摘要： The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
摘要翻译： 本发明提供了一种针对莱姆病的疫苗，其中含有一种或多种对伯氏疏螺旋体31kD抗原（OspA）或34kD抗原（OspB）特异的单克隆抗体。 本发明还提供了获得该疫苗的方法，以及新的单克隆抗体和抗原。
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2.发明授权Hybridomas producing antibodies specific for lyme disease antigens OspA and OspB 失效产生针对淋巴细胞疾病抗原OspA和OspB特异性抗体的杂交瘤
公开(公告)号：US5856447A
公开(公告)日：1999-01-05
申请号：US27843
申请日：1998-02-23
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/20 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/31 , C12N15/56 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , G01N33/577 , A61K31/395
CPC分类号： C12N1/20 , C07K14/20 , C07K16/1207 , A61K38/00 , A61K39/00
摘要： The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies, hybridomas and antigens.
摘要翻译： 本发明提供了一种针对莱姆病的疫苗，其中含有一种或多种对伯氏疏螺旋体31kD抗原（OspA）或34kD抗原（OspB）特异的单克隆抗体。 本发明还提供了获得该疫苗的方法，以及新的单克隆抗体，杂交瘤和抗原。
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公开(公告)号：US5686267A
公开(公告)日：1997-11-11
申请号：US407350
申请日：1995-03-20
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/20 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/31 , C12N15/56 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , G01N33/577 , C12P21/06 , C07H21/02
CPC分类号： C12N1/20 , C07K14/20 , C07K16/1207 , A61K38/00 , A61K39/00
摘要： A vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
摘要翻译： 针对莱姆病的疫苗，其中含有一种或多种针对勃氏疏螺旋体的31kD抗原（OspA）或34kD抗原（OspB）特异性的单克隆抗体。 本发明还提供了获得该疫苗的方法，以及新的单克隆抗体和抗原。
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公开(公告)号：US5780030A
公开(公告)日：1998-07-14
申请号：US406623
申请日：1995-03-20
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/20 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/31 , C12N15/56 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , G01N33/577
CPC分类号： C12N1/20 , C07K14/20 , C07K16/1207 , A61K38/00 , A61K39/00
摘要： The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal anti-bodies and antigens.
摘要翻译： 本发明提供了一种针对莱姆病的疫苗，其中含有一种或多种对伯氏疏螺旋体31kD抗原（OspA）或34kD抗原（OspB）特异的单克隆抗体。 本发明还提供了获得该疫苗的方法，以及新的单克隆抗体和抗原。
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公开(公告)号：US5178859A
公开(公告)日：1993-01-12
申请号：US585310
申请日：1990-09-19
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/20 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/31 , C12N15/56 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , G01N33/577
CPC分类号： C12N1/20 , C07K14/20 , C07K16/1207 , A61K38/00 , A61K39/00
摘要： The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
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公开(公告)号：US5434077A
公开(公告)日：1995-07-18
申请号：US068063
申请日：1993-05-27
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/20 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/31 , C12N15/56 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , G01N33/577 , C12N1/00
CPC分类号： C12N1/20 , C07K14/20 , C07K16/1207 , A61K38/00 , A61K39/00
摘要： The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
摘要翻译： 本发明提供了一种针对莱姆病的疫苗，其中含有一种或多种对伯氏疏螺旋体31kD抗原（OspA）或34kD抗原（OspB）特异的单克隆抗体。 本发明还提供了获得该疫苗的方法，以及新的单克隆抗体和抗原。
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