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公开(公告)号：US20240002846A1
公开(公告)日：2024-01-04
申请号：US18032103
申请日：2021-10-15
Applicant: Duke University , Universidad Nacional Autónoma de México , Wake Forest University Health Sciences
Inventor： Wolfgang Liedtke , Yong Chen , Tamara Rosenbaum , Tony Elvern Reeves
IPC: C12N15/113 , G01N33/68 , A61P17/04
CPC classification number: C12N15/113 , G01N33/6872 , G01N33/6893 , A61P17/04 , G01N2800/20 , G01N2500/04 , C12N2310/141
Abstract: Disclosed herein are compositions and methods for treating a subject having an itch-related disorder, such as dermatological disorders or systemic disorders comprising itch. The methods may include determining the level of a biomarker in a biological sample from the subject. The biomarker may be selected from TRPV4 expression, lysophosphatidylcholine, and miRNA-146a expression, or a combination thereof. The subject may be identified as having the itch-related disorder when the level of the biomarker is greater in a sample from the subject than in a control. An anti-pruritic therapy may be administered to treat the subject having the itch-related disorder.
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公开(公告)号：US20200222495A1
公开(公告)日：2020-07-16
申请号：US16302786
申请日：2017-05-18
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Edda Lydia Sciutto Conde , Gladis del Carmen Fragoso Gonzalez , Diana Torres Garcia , Jacquelynne Brenda Cervantes Torres , Rene Alvaro Segura Velazquez , Armando Perez Torres , Karen Manucharyan
Abstract: The present invention refers to the use of the peptide defined by the amino acid sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A, named GK-1, to be used as an antitumor and antimetastatic agent or for the treatment of cancer, specifically of basal cell carcinoma, squamous cell carcinoma, transitional cell carcinoma, and adenocarcinoma, and preferably for the treatment of breast cancer.
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公开(公告)号：US10793611B2
公开(公告)日：2020-10-06
申请号：US16302261
申请日：2017-04-18
Applicant: Universidad Nacional Autónoma de México
IPC: A61K38/00 , C07K14/325 , A01N63/10
Abstract: The disclosure provides nucleic acids encoding variant polypeptides having pesticidal activity against insect pests, including Lepidoptera and Diptera. Particular embodiments provide isolated nucleic acids encoding Cyt1A variant polypeptides, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, particularly Diptera pests.
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公开(公告)号：US11478896B2
公开(公告)日：2022-10-25
申请号：US16467316
申请日：2017-11-08
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Erika Sohn López-Forment , Elfego Guillermo Ruiz Schneider , Luis Salas Casales , Esteban Antolin Luna Aguilar
Abstract: A hydrodynamically optimized mixer module, to be coupled to a deterministic hydrodynamic tool that allows pulsed polishing of optical surfaces is described. This module allows the supply of abrasive foam or fluid that enters the tool to be interrupted without impairing the operational stability of the polishing process and of said hydrodynamic tool. The mixer module includes at least one interrupter element for switching high-velocity fluids; a first inlet through which air is injected under pressure and in a controlled manner; a second inlet through which a polishing fluid is injected in a controlled manner, said polishing fluid filling a predetermined volume with a hydrodynamically optimized shape and being transferred to a mixing zone where, together with the pressure-injected air, an abrasive foam is produced that is injected into at least one rotational acceleration chamber of the hydrodynamic tool to which the mixer module is coupled.
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公开(公告)号：US11020449B2
公开(公告)日：2021-06-01
申请号：US16302786
申请日：2017-05-18
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Edda Lydia Sciutto Conde , Gladis del Carmen Fragoso Gonzalez , Diana Torres Garcia , Jacquelynne Brenda Cervantes Torres , Rene Alvaro Segura Velazquez , Armando Perez Torres , Karen Manucharyan
Abstract: The present invention refers to the use of the peptide defined by the amino acid sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A, named GK-1, to be used as an antitumor and antimetastatic agent or for the treatment of cancer, specifically of basal cell carcinoma, squamous cell carcinoma, transitional cell carcinoma, and adenocarcinoma, and preferably for the treatment of breast cancer.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180327780A1
公开(公告)日：2018-11-15
申请号：US15577404
申请日：2016-05-26
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Rafael Vazquez Duhalt , Lorena Paulina Sanchez Sanchez
IPC: C12N15/86 , C12N9/02 , A61K9/51 , C07K14/705 , A61K38/44 , A61K38/17 , A61K45/06 , A61K38/16 , C07K14/47 , C07K14/24 , A61K47/69
Abstract: Hybrid proteins with cytochrome P450 activity and which are encapsulated in a nanocapsid (nanoparticles charged with cytochrome P450 activity) are designed and synthesized, these hybrid proteins being immunologically inert and recognized by breast cancer cells.
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7.发明授权公开(公告)号：US09773154B2
公开(公告)日：2017-09-26
申请号：US14879466
申请日：2015-10-09
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Blanca Elena Jiménez Cisneros , Catalina Maya Rendón , Gustavo Adolfo Rodrigo Velásquez Rodríguez , José Antonio Barrios Pérez , Fernando Arámbula Cosio
CPC classification number: G06K9/0014 , G06K9/00147 , G06K2009/4666 , G06T7/0012 , G06T7/62 , G06T2207/10056 , G06T2207/30024
Abstract: Process and system for identifying and quantifying helminth eggs in water, sludge, biosolid and/or excreta samples among others, from images comprising filtering the images with an anisotropic filter maintaining the borders of the images, obtaining filtered images; filtering the filtered images applying Laplacian of Gaussian detecting changes in the filtered images, and obtaining binarized images; separating the binarized images by means of a filtered distance field Watershed filter, obtaining the images; filtering the images eliminating objects by perimeter compactness, considering the size of the objects in the images filtered again and separating the differences to avoid false positives, obtaining images with identified objects; characterizing the objects identified in the images segmenting the objects by means of gray profiles; and classifying the characterized objects according to a statistic classifier for identifying and quantifying different species of helminth eggs.
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8.发明申请USE OF TAENIA SOLIUM RECOMBINANT CALRETICULIN FOR INDUCING INTERLEUKIN-10 EXPRESSION 审中-公开使用TAIAIA SOLIUM重组蛋白激酶诱导白细胞介素-10表达公开(公告)号：US20160058835A1
公开(公告)日：2016-03-03
申请号：US14888858
申请日：2014-04-21
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Fela MENDLOVIC PASOL , Ana FLISSER STEINBRUCH
IPC: A61K38/17
CPC classification number: A61K38/1767 , A61K38/1709
Abstract: The present invention is related to the use of a recombinant protein to induce interleukin 10 expression, wherein the protein is Taenia solium parasite recombinant calreticulin (rTsCRT) formulated in a physiologic glycosated solution orally or parenterally administered. The used methodology for rTsCRT expression and purification described in present invention, resulted in a recombinant protein expressed without post-translational modifications having regulatory immunological effects and capable of stimulating the mRNA transcription levels which codify for IL-4 and IL-10 cytokines. rTsCRT expression is conducted in an E. coli untagged system, though applicable to any expression system, whether prokaryote or eukaryote cells. The purpose of producing rTsCRT is to use it for treatment of local or systemic inflammatory diseases.
Abstract translation: 本发明涉及重组蛋白质用于诱导白细胞介素10表达的用途，其中所述蛋白质是口服或肠胃外给药的生理糖基化溶液中配制的绦虫寄生虫重组钙网蛋白（rTsCRT）。 用于本发明描述的rTsCRT表达和纯化的所用方法导致不具有调节免疫学作用且能够刺激编码IL-4和IL-10细胞因子的mRNA转录水平的翻译后修饰的表达的重组蛋白。 rTsCRT表达在大肠杆菌未标记的系统中进行，尽管适用于任何表达系统，无论是原核生物还是真核细胞。 生产rTsCRT的目的是用于治疗局部或全身炎性疾病。
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公开(公告)号：US20240391980A1
公开(公告)日：2024-11-28
申请号：US18696922
申请日：2022-09-30
Inventor： Rebecca Dubois , Lena Ricemeyer , Carlos F. Arias Ortiz , Tomás López Díaz , Rafaela Espinosa Organista
Abstract: Provided are antibodies that specifically bind human astrovirus (HAstV) capsid spike protein. Fusion proteins and conjugates comprising such antibodies are also provided. Also provided are nucleic acids that encode one or both of the variable chain polypeptides of an antibody of the present disclosure, as are cells that include such nucleic acids. Also provided are compositions that include the antibodies of the present disclosure, including in some instances, pharmaceutical compositions. Methods of making and using the antibodies of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having or suspected of having a HAstV infection a therapeutically effective amount of an antibody, fusion protein or conjugate of the present disclosure.
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10.发明申请公开(公告)号：US20200010802A1
公开(公告)日：2020-01-09
申请号：US16335884
申请日：2017-09-25
Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventor： Andrés Eliú CASTELL RODRÍGUEZ , Miguel Ángel HERRERA ENRÍQUEZ , Gabriela PINÓN ZÁRATE , Katia JARQUÍN YÁNEZ , Casandra CHAIRES ROSAS , Rosa María ARELLANO OLIVARES
IPC: C12N5/071 , C12P21/00 , A61K35/36 , A61L27/54 , A61L27/58 , A61L27/60 , A61L27/36 , C12N5/077 , A61K35/33 , C12N5/073 , A61P17/02
Abstract: A method for preparing a supplement from mesenchymal cell cultures of Wharton's jelly including factors to favor the culture growth of cells from cutaneous system, in vitro, and to methods for producing epidermal, dermal, or cutaneous equivalents, and which may also be used as supplement for the proliferation and activation of autologous fibroblasts for subsequent intradcrmal use.
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