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    Tissue equivalent for transplantation and method for producing same
    1.
    发明申请
    Tissue equivalent for transplantation and method for producing same 审中-公开
    移植组织等价物及其生产方法

    公开(公告)号：US20070172812A1

    公开(公告)日：2007-07-26

    申请号：US11727521

    申请日：2007-03-27

    Applicant: Mitsuo Ochi ,  Yuji Uchio ,  Kenzo Kawasaki ,  Masakazu Katoh ,  Takeyuki Yamamoto ,  Rika Fukushima ,  Toyokazu Kurushima

    Inventor： Mitsuo Ochi ,  Yuji Uchio ,  Kenzo Kawasaki ,  Masakazu Katoh ,  Takeyuki Yamamoto ,  Rika Fukushima ,  Toyokazu Kurushima

    IPC: A01N1/02 ,  C12N5/08 ,  C12N5/06

    CPC classification number: A61L27/3821 ,  A61L27/3633 ,  A61L27/3817 ,  A61L27/3895

    Abstract: A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which is localized at least in a part of the surface of the tissue equivalent for transplantation continuously with the scaffold layer and which contains the cells to be transplanted or extra cellular matrix in a larger amount than the scaffold layer. This tissue equivalent is appropriately employed as a tissue equivalent for transplantation in a relatively large size. This tissue equivalent enables realization of prompt fixation to the neighborhood of the transplanted tissue and prevention of falling off.

    Abstract translation: 具有体外培养的具有三维结构的移植组织当量含有待移植的细胞，并且可以在培养后移植到生物体中，其特征在于包括主要培养构成三维的支架的支架层 结构和细胞层，其至少在组织的表面的一部分中等同于与支架层连续移植，并且其含有比支架层更大量的要移植的细胞或细胞外基质。 这种组织当量适当地用作相对较大尺寸移植的组织当量。 这种组织等效使得能够实现对移植组织附近的迅速固定并防止脱落。

    Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit
    3.
    发明授权
    Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit 有权
    使用具有振动检测单元的刚度测量装置测量培养组织的刚度的方法

    公开(公告)号：US07198908B2

    公开(公告)日：2007-04-03

    申请号：US10921339

    申请日：2004-08-19

    Applicant: Mitsuo Ochi ,  Junji Iwasa ,  Masatoshi Tobita ,  Masakazu Katoh ,  Takeyuki Yamamoto ,  Rika Fukushima ,  Toyokazu Kurushima

    Inventor： Mitsuo Ochi ,  Junji Iwasa ,  Masatoshi Tobita ,  Masakazu Katoh ,  Takeyuki Yamamoto ,  Rika Fukushima ,  Toyokazu Kurushima

    IPC: C12P1/00

    CPC classification number: G01N3/32 ,  G01N3/405 ,  G01N2203/0005 ,  G01N2203/0051 ,  G01N2203/0676 ,  G01N2203/0682 ,  G01N2203/0688

    Abstract: To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.

    Abstract translation: 为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器 连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。 通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

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