公开(公告)号：US5276058A

公开(公告)日：1994-01-04

申请号：US73423

申请日：1993-06-09

申请人： Toshio Satoh ,  Hitoshi Matsumoto ,  Yasunori Niiro

发明人： Toshio Satoh ,  Hitoshi Matsumoto ,  Yasunori Niiro

IPC分类号： A61K31/12 ,  C07C49/835 ,  C07C49/84 ,  C07C225/22 ,  A61K31/135

CPC分类号： A61K31/12 ,  C07C225/22 ,  C07C49/835 ,  C07C49/84

摘要： Novel 3,4-dihydroxychalcone derivatives useful as a pharmaceutical material, and novel anti-inflammatory preparations. The 3,4-dihydroxychalcone derivatives are compounds of the formula [I], ##STR1## wherein X is a substituted phenyl group represented, e.g., by the formula (i), ##STR2## in which R.sup.1 is a hydrogen atom or an alkyl group and R.sup.2 is an alkyl group, an alkoxy group or an --OH group (excluding an OH-group in the 4-position)or salts thereof. The anti-inflammatory preparations contain one of the above 3,4-dihydroxychalcone derivatives as an active ingredient.

摘要翻译： 用作药物的新型3,4-二羟基查耳酮衍生物和新型抗炎制剂。 3,4-二羟基查耳酮衍生物是式（I）化合物，（*化学结构*）（I）其中X是以式（ⅰ）代表的取代苯基，（*化学结构*）（ i）其中R1是氢原子或烷基，R2是烷基，烷氧基或-OH基团（不包括4-位OH基）或其盐。 抗炎制剂含有上述3,4-二羟基查耳酮衍生物之一作为有效成分。

公开(公告)号：US5109025A

公开(公告)日：1992-04-28

申请号：US543845

申请日：1990-07-25

申请人： Toshio Satoh ,  Hitoshi Matsumoto ,  Hisao Kakegawa

发明人： Toshio Satoh ,  Hitoshi Matsumoto ,  Hisao Kakegawa

IPC分类号： A61K31/12

CPC分类号： A61K31/12

摘要： 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.

摘要翻译： PCT No.PCT / JP89 / 01197 Sec。 371日期1990年7月25日第 102（e）日期1990年7月25日PCT 1989年11月24日PCT公布。 出版物WO90 / 06108 日期：1990年6月14日，3,4,4'-四羟基查耳酮及其药理学上可接受的盐被用作治疗肾脏疾病的治疗剂，并且具有治疗肾脏疾病的活性，还用于治疗伴随着 消化系统疾病和/或一般炎症和/或过敏性疾病。

公开(公告)号：US5061812A

公开(公告)日：1991-10-29

申请号：US382270

申请日：1989-07-20

申请人： Toshio Satoh ,  Yasunori Niiro ,  Hisao Kakegawa ,  Hitoshi Matsumoto

发明人： Toshio Satoh ,  Yasunori Niiro ,  Hisao Kakegawa ,  Hitoshi Matsumoto

IPC分类号： C07D307/62 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04

CPC分类号： C07D405/12 ,  C07D307/62 ,  C07D405/14 ,  C07D407/04

摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.

摘要翻译： 本发明涉及一种具有优异抗氧化作用的新型抗坏血酸衍生物及其制备方法。 此外，本发明还涉及包含上述抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

公开(公告)号：US5053490A

公开(公告)日：1991-10-01

申请号：US323150

申请日：1989-03-13

申请人： Toshio Satoh ,  Hitoshi Matsumoto ,  Kakegawa Hisao

发明人： Toshio Satoh ,  Hitoshi Matsumoto ,  Kakegawa Hisao

IPC分类号： A61K38/38 ,  A61K47/42 ,  A61K47/48

CPC分类号： A61K38/38 ,  A61K47/42 ,  A61K47/48284

摘要： A powdery complex is obtained by combining a useful substance such as vitamin E and liquid fatty oil with albumin. This powdery complex has excellent storage stability and can keep the useful substance contained therein stably for a long time.

摘要翻译： 通过将有用物质如维生素E和液体脂肪油与白蛋白结合，获得粉状复合物。 这种粉状复合物具有优异的储存稳定性，并且可以长时间保持其中所含有用物质的稳定性。

公开(公告)号：US5034543A

公开(公告)日：1991-07-23

申请号：US382269

申请日：1989-07-20

申请人： Toshio Satoh ,  Yasunori Niiro ,  Hisao Kakegawa ,  Hitoshi Matsumoto

发明人： Toshio Satoh ,  Yasunori Niiro ,  Hisao Kakegawa ,  Hitoshi Matsumoto

IPC分类号： C07D405/14 ,  C07D407/04 ,  C09K15/06

CPC分类号： C07D405/14 ,  C07D407/04 ,  C09K15/06

摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.

摘要翻译： 本发明涉及具有优异抗氧化作用的抗坏血酸衍生物，特别是除去对超氧化物的作用及其制备方法。 此外，本发明还涉及包含上述新型抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

公开(公告)号：US4681895A

公开(公告)日：1987-07-21

申请号：US836711

申请日：1986-03-06

申请人： Toshio Satoh ,  Goro Tsukamoto

发明人： Toshio Satoh ,  Goro Tsukamoto

IPC分类号： A61K31/195 ,  A61K31/196 ,  A61K31/245 ,  A61P1/04 ,  C07C67/00 ,  C07C239/00 ,  C07C279/14 ,  C07K5/02 ,  C07C129/00

CPC分类号： A61K31/245 ,  C07K5/02 ,  Y10S514/927

摘要： Novel N-phenyl-trans-4-guanidinomethylcyclohexanecarboxamide compounds of the formula: ##STR1## wherein R is hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which have excellent anti-ulcer activities and hence are useful as an anti-ulcer drug, and a pharmaceutical composition useful for the treatment and prophylaxis of peptic ulcers which comprises as an active ingredient the compound as set forth above in admixture with a conventional pharmaceutically acceptable carrier or diluent.

摘要翻译： 新型N-苯基 - 反-4-胍基甲基环己烷甲酰胺化合物，其结构式如下：其中R是氢原子或低级烷基，或其药学上可接受的盐，其具有优异的抗溃疡活性，因此可用作抗 以及用于治疗和预防消化性溃疡的药物组合物，其包含与常规药学上可接受的载体或稀释剂混合的作为活性成分的上述化合物。

公开(公告)号：US4433152A

公开(公告)日：1984-02-21

申请号：US379714

申请日：1982-05-19

申请人： Mutsumi Muramatsu ,  Toshio Satoh ,  Hiroyasu Sekine ,  Atsushi Tendo ,  Yoshio Kikawa ,  Kaname Kondo

发明人： Mutsumi Muramatsu ,  Toshio Satoh ,  Hiroyasu Sekine ,  Atsushi Tendo ,  Yoshio Kikawa ,  Kaname Kondo

IPC分类号： C07D211/08 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D401/12 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D409/12

摘要： A compound of the formula, ##STR1## wherein R represents a hydrogen atom, a naphthyl, indanyl, tetrahydronaphthyl or pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, and an alkyl, alkenyl, alkoxy, alkanoyl, cyano, formyl, trifluoromethyl, phenyl, phenylalkyl, alkanoyl-amino, aminosulfonyl, carboxyl, alkoxycarbonyl, benzyloxycarbonyl, benzoylvinyl, phenylvinylcarbonyl, carboxyvinyl, and diphenyl-methyloxycarobnylvinyl group, A represents an oxygen or sulfur atom, and n represents an integer of 0 to 3, with the proviso that when n is an integer of 0, R must not be a hydrogen atom, or a pharmaceutically acceptable salt thereof is effectively useful for inhibiting a complement reaction, inflammation caused by an allergic reaction, and platelet aggregation.

摘要翻译： 下式的化合物，其中R表示氢原子，萘基，茚满基，四氢萘基或吡啶基，或可具有1至3个选自卤素原子和烷基的烷基的苯基 烯基，烷氧基，烷酰基，氰基，甲酰基，三氟甲基，苯基，苯基烷基，烷酰基 - 氨基，氨基磺酰基，羧基，烷氧基羰基，苄氧基羰基，苯甲酰基乙烯基，苯基乙烯基羰基，羧基乙烯基和二苯基甲氧基草酰乙烯基，A表示氧或硫原子， n表示0〜3的整数，条件是当n为0的整数时，R不能为氢原子，或其药学上可接受的盐可有效用于抑制补体反应，由过敏反应引起的炎症 ，和血小板聚集。

公开(公告)号：US4216357A

公开(公告)日：1980-08-05

申请号：US743661

申请日：1976-11-22

申请人： Norio Iwasaki ,  Toshio Satoh ,  Hiroyuki Ito ,  Ikuya Koike

发明人： Norio Iwasaki ,  Toshio Satoh ,  Hiroyuki Ito ,  Ikuya Koike

IPC分类号： G11B3/095 ,  G10H1/18 ,  G10H5/00 ,  G11B7/00 ,  G11B7/003 ,  G11B7/005 ,  G11B7/09 ,  H04N5/76 ,  H04N5/85 ,  G11B11/00 ,  G11B7/12

CPC分类号： G11B7/0925 ,  G10H1/34 ,  G10H3/06 ,  G11B7/09

摘要： This invention relates to a system for optically playing back recorded signals from a recorded medium on which signals of images or sounds are continuously recorded so as to constitute a signal recorded line or signal track. In play-back the images or sounds are optically recognized by the width-change of the signal recorded line. A narrow light beam for the play-back is deflected at a predetermined frequency in the direction perpendicular to the signal recorded line, i.e. in the direction of the width of the signal recorded line, in order to perform the optical scanning. The narrow light beam which is reflected or transmitted on the recorded medium surface reaches photo-sensitive elements such as photo-diodes. Electrical outputs obtained from the photo-sensitive elements are relatively compared with electric signals (standard pulses) obtained from fundamental electric signals for deflecting the said narrow light beam at a predetermined frequency, so that the amplitude of the recorded signal at each differential point of the signal recorded line is continuously detected as length-amount, and a modulated wave is continuously obtained from the length-amount. The modulated wave is further decoded, compensated, and amplified so as to obtain the play-back signals corresponding to the continuous width-change of the signal recorded line. The play-back system is provided with a tracking mechanism by which the play-back mechanism can follow the signal recorded line, and an interval adjusting mechanism for maintaining the vertical interval between the play-back mechanism and the signal recorded line uniform.

摘要翻译： 本发明涉及一种用于光学地从记录介质上重放记录的信号的系统，其上连续地记录有图像或声音的信号，以构成信号记录的行或信号轨道。 在播放时，图像或声音由信号记录行的宽度变化而被光学识别。 用于播放的窄光束在垂直于信号记录线的方向上，即在信号记录行的宽度方向上以预定频率偏转，以执行光学扫描。 在记录介质表面上被反射或透射的窄光束到达光敏元件如光电二极管。 从光敏元件获得的电输出与从基本电信号获得的电信号（标准脉冲）相比较，用于以预定频率偏转所述窄光束，使得在每个差分点处的记录信号的幅度 信号记录线被连续检测为长度量，并且从长度量连续地获得调制波。 调制波被进一步解码，补偿和放大，以获得与信号记录行的连续宽度变化相对应的重放信号。 回放系统设置有跟踪机构，通过该跟踪机构，回放机构可以跟随信号记录线，以及间隔调整机构，用于保持回放机构和信号记录线之间的垂直间隔均匀。

公开(公告)号：US06190694B1

公开(公告)日：2001-02-20

申请号：US09416183

申请日：1999-10-11

申请人： Yutaka Mizushima ,  Yasuo Kosaka ,  Toshio Satoh

发明人： Yutaka Mizushima ,  Yasuo Kosaka ,  Toshio Satoh

IPC分类号： A61K948

CPC分类号： A61K9/4858

摘要： The present invention relates to a process for producing a chitosan-containing soft capsule. The process includes the steps of rendering chitosan a powder; adding the chitosan powder, powder comprising an organic acid and a salt thereof, and an emulsifier to an oil or fat; stirring the resultant mixture so as to suspend the powders, to thereby obtain a gel-like stock; and feeding the gel-like stock and a gelatin solution for coating into an automated encapsulation machine, to effect encapsulation of the stock with gelatin.

摘要翻译： 本发明涉及含有壳聚糖的软胶囊的制造方法。 该方法包括使壳聚糖成粉末的步骤; 将壳聚糖粉末，包含有机酸及其盐的粉末和乳化剂加入到油或脂肪中; 搅拌所得混合物以使粉末悬浮，从而获得凝胶状原料; 并将凝胶状原料和明胶溶液加入到自动封装机中，以明胶包封原料。

公开(公告)号：US5351225A

公开(公告)日：1994-09-27

申请号：US877429

申请日：1992-05-01

申请人： Takashi Ishida ,  Shunji O'Hara ,  Kenzo Ishibashi ,  Toshio Satoh

发明人： Takashi Ishida ,  Shunji O'Hara ,  Kenzo Ishibashi ,  Toshio Satoh

IPC分类号： G11B7/09

CPC分类号： G11B7/0946

摘要： In an optical recording and reproducing apparatus which forms at least first and second light spots on a track of an optical recording medium to record, reproduce or erase information, a movable range of the second light spot is limited to less than one half of a track pitch, normal to the track, from the track to prevent tracks other than a target track from being miserased, misrecorded or misreproduced. When a deviation of the second light spot from the target track exceeds a predetermined amount, light emission of the second light spot is stopped to prevent a track other than the target track from being miserased, misrecorded or misreproduced. When the deviation of the second light spot from the target track exceeds the predetermined amount, the second light spot is returned to a neutral position to prevent a track other than the target track from being miserased, misrecorded or misreproduced.

摘要翻译： 在光学记录和再现装置中，其至少在光学记录介质的轨道上形成第一和第二光斑以记录，再现或擦除信息，第二光斑的可移动范围被限制在小于轨道的一半 从轨道正常的轨道，以防止目标轨道以外的轨迹被歪曲，误记或错误地产生。 当第二光点与目标轨迹的偏差超过预定量时，停止第二光点的发光，以防止除了目标轨迹以外的轨迹被误导，误记或错误地产生。 当第二光点与目标轨道的偏差超过预定量时，第二光点返回到中立位置，以防止目标轨道以外的轨迹被误导，误记或错误地产生。