公开(公告)号：US20110169152A1

公开(公告)日：2011-07-14

申请号：US13053822

申请日：2011-03-22

申请人： Stephen St. Germain ,  Roger M. Arbuthnot ,  Frank Tim Jones

发明人： Stephen St. Germain ,  Roger M. Arbuthnot ,  Frank Tim Jones

IPC分类号： H01L23/495

CPC分类号： H01L23/49562 ,  H01L23/3107 ,  H01L23/49548 ,  H01L24/34 ,  H01L2224/26175 ,  H01L2224/32245 ,  H01L2224/73253 ,  H01L2224/83801 ,  H01L2224/8385 ,  H01L2224/84801 ,  H01L2224/8485 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/01087 ,  H01L2924/014 ,  H01L2924/1305 ,  H01L2924/1306 ,  H01L2924/13091 ,  H01L2924/14 ,  H01L2924/00 ,  H01L2224/37099

摘要： In one embodiment, a semiconductor package is formed to include a leadframe that includes a plurality of die attach areas for attaching a semiconductor die to the leadframe. The leadframe is positioned to overlie another leadframe that forms some of the external terminals or leads of the package.

摘要翻译： 在一个实施例中，半导体封装被形成为包括引线框架，该引线框架包括用于将半导体管芯附接到引线框架的多个管芯附着区域。 引线框定位成覆盖形成封装的一些外部端子或引线的另一引线框架。

公开(公告)号：US07456257B2

公开(公告)日：2008-11-25

申请号：US10546112

申请日：2004-02-18

申请人： Tim Jones ,  Matthew Baker ,  Marian Hanlon ,  Francis Joseph Carr

发明人： Tim Jones ,  Matthew Baker ,  Marian Hanlon ,  Francis Joseph Carr

IPC分类号： C07K14/00

CPC分类号： A61K38/212 ,  C07K14/56 ,  C07K2319/30

摘要： The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

摘要翻译： 本发明涉及人类干扰素α，特别涉及具有改进性质的干扰素α2的修饰形式。 改进的蛋白质在特定位置含有氨基酸取代，其在生物测定中赋予增加的相对活性。 本发明还提供修饰的干扰素α，其具有改善的生物活性，伴随蛋白质中的免疫原性潜力降低。 改进的蛋白质用于治疗人类疾病的治疗用途。

公开(公告)号：USD565145S1

公开(公告)日：2008-03-25

申请号：US29277295

申请日：2007-02-21

申请人： Bruce R. Studer ,  Tim Jones

设计人： Bruce R. Studer ,  Tim Jones

公开(公告)号：USD564061S1

公开(公告)日：2008-03-11

申请号：US29277279

申请日：2007-02-20

申请人： Bruce R. Studer ,  Tim Jones

设计人： Bruce R. Studer ,  Tim Jones

公开(公告)号：US07010548B2

公开(公告)日：2006-03-07

申请号：US10609289

申请日：2003-06-27

申请人： M. Tim Jones ,  Scott Smallwood

发明人： M. Tim Jones ,  Scott Smallwood

IPC分类号： G06F7/06

CPC分类号： H04L67/1097 ,  H04L1/1829 ,  H04L69/16 ,  H04L69/163 ,  H04L69/324 ,  Y10S707/99945 ,  Y10S707/99948

摘要： A method and system for tracking data packets that utilizes a tree data structure with a recursive pruning algorithm that collapses the branches of the tree that represent contiguous ranges or regions to maintain a minimally optimum memory size. Each contiguous region is identified by a node, which includes the start and end range of packets. Each node further includes left and right pointer elements, which point to adjacent lower and higher nodes, respectively. When a packet sequence number is not contiguous with any other sequence numbers previously received, a new node is created that contains only a single value range. When a new packet is received that has a contiguous sequence number (i.e., immediately preceding or succeeding sequence number), the original node is updated so as to reflect the new contiguous range. Additionally, if this new contiguous range is contiguous with another node's range, the two nodes are “collapsed” into a new single node containing the new expanded contiguous range. Furthermore, the algorithm can quickly and efficiently determine whether there are any missing packets by simply determining if there is only a single node remaining after a designated “last packet” has been received.

摘要翻译： 一种用于跟踪使用具有递归修剪算法的树数据结构的数据分组的方法和系统，该递归修剪算法折叠表示连续范围或区域的树的分支以维持最小最优的存储器大小。 每个连续区域由包括数据包的开始和结束范围的节点来标识。 每个节点还包括分别指向相邻的较低和较高节点的左和右指针元素。 当分组序列号与先前接收的任何其他序列号不连续时，将创建仅包含单个值范围的新节点。 当接收到具有连续序列号（即紧接在前面或后面的序列号）的新分组时，更新原始节点以便反映新的连续范围。 另外，如果这个新的连续范围与另一个节点的范围相邻，则两个节点被“折叠”到包含新的扩展的连续范围的新的单个节点中。 此外，通过简单地确定在接收到指定的“最后一个分组”之后是否只剩下一个节点，该算法可以快速有效地确定是否存在丢失的分组。

公开(公告)号：US06884623B1

公开(公告)日：2005-04-26

申请号：US09304967

申请日：1999-05-05

申请人： George P. Lomonossoff ,  John E. Johnson ,  Mary Bendig ,  Tim Jones ,  Marian Longstaff

发明人： George P. Lomonossoff ,  John E. Johnson ,  Mary Bendig ,  Tim Jones ,  Marian Longstaff

IPC分类号： A61K39/12 ,  A61K38/00 ,  A61K39/00 ,  A61P31/12 ,  A61P37/02 ,  C07K14/08 ,  C07K14/09 ,  C07K14/095 ,  C07K14/16 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12N15/09 ,  C12N15/62 ,  C12N15/82 ,  C12N15/83 ,  C12N5/04 ,  C12N15/63

CPC分类号： C12N15/8258 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/735 ,  C12N15/62 ,  C12N15/8203 ,  C12N15/8257 ,  C12N2740/16122 ,  C12N2770/18022 ,  C12N2770/32122 ,  C12N2770/32722 ,  Y02A50/464

摘要： The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is preferably free from direct sequence repeats flanking the insert. The invention relates to a method of production of the particles and their use, in particular in vaccines.

摘要翻译： 本发明涉及在病毒的外壳蛋白中含有外来肽插入物的植物病毒的组装颗粒。 插入物的位点优选不存在插入物侧翼的直接序列重复。 本发明涉及一种生产颗粒的方法及其用途，特别是在疫苗中。

公开(公告)号：US20050054052A1

公开(公告)日：2005-03-10

申请号：US10471894

申请日：2002-03-15

申请人： Francis Carr ,  Graham Carter ,  Tim Jones ,  John Watkins

发明人： Francis Carr ,  Graham Carter ,  Tim Jones ,  John Watkins

IPC分类号： C12N15/09 ,  A61K38/21 ,  A61K39/00 ,  A61P31/12 ,  A61P37/02 ,  C07K7/08 ,  C07K14/565 ,  C12N15/22 ,  C12P21/02 ,  C07H21/04 ,  C07K14/765 ,  C12P21/04

CPC分类号： C07K14/565

摘要： The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human interferon beta to result in proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

摘要翻译： 本发明涉及特别用于人，特别是用于治疗用途的多肽。 所述多肽是修饰的多肽，其中所述修饰导致多肽在施用于人受试者时引起免疫应答的倾向降低。 本发明特别涉及人类干扰素β的修饰，以产生当在体内使用时与任何未修饰的对应物基本上不具有免疫原性或较低免疫原性的蛋白质。

公开(公告)号：US5895229A

公开(公告)日：1999-04-20

申请号：US858756

申请日：1997-05-19

申请人： Francis J. Carney ,  George Amos Carson ,  Phillip C. Celaya ,  Harry Fuerhaupter ,  Frank Tim Jones ,  Donald H. Klosterman ,  Cynthia M. Melton ,  James Howard Knapp ,  Keith E. Nelson

发明人： Francis J. Carney ,  George Amos Carson ,  Phillip C. Celaya ,  Harry Fuerhaupter ,  Frank Tim Jones ,  Donald H. Klosterman ,  Cynthia M. Melton ,  James Howard Knapp ,  Keith E. Nelson

IPC分类号： H01L21/56 ,  H01L23/31 ,  H01L21/44 ,  H01L21/48

CPC分类号： H01L21/565 ,  H01L21/561 ,  H01L23/3121 ,  H01L24/97 ,  H01L2224/05568 ,  H01L2224/05573 ,  H01L2224/16 ,  H01L2224/16225 ,  H01L2224/16227 ,  H01L2224/16235 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/09701 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/15311

摘要： A microelectronic package (10) is formed and includes an integrated circuit die (12) attached to a substrate (14) by a plurality of solder bump interconnections (16) to form a preassembly (18). The integrated circuit die (12) has an active face (20) that faces the substrate (14) and is spaced apart therefrom by a gap (22). The integrated circuit die (12) also includes a back face (24) opposite the active face (20). The substrate (14) includes a die attach region (26) and a surrounding region (28) about the integrated circuit die (12). The solder bump interconnections (16) extend across the gap (22) and connect the integrated circuit die (12) and the substrate (14). A mold (30) is disposed about the preassembly (18) such that the mold (30) cooperates with the substrate (14) to define a mold cavity (32) that encloses the integrated circuit die (12). The mold (30) has a molding surface (34) that includes the surrounding region (28) and a mold surface (34) that faces the back face (24) and is spaced apart therefrom. A polymeric precursor (36) is dispensed into the mold cavity (32) and is formed against the molding surface (34) and the back face (24). The polymeric precursor (36) is then cured to form a polymeric encapsulant (38) that encapsulates the integrated circuit die (12).

摘要翻译： 形成微电子封装（10）并且包括通过多个焊料凸块互连（16）附接到衬底（14）以形成预组件（18）的集成电路管芯（12）。 集成电路管芯（12）具有面向衬底（14）并与间隔开的间隙（22）的有效面（20）。 集成电路管芯（12）还包括与有源面（20）相对的背面（24）。 衬底（14）包括管芯附接区域（26）和围绕集成电路管芯（12）的周围区域（28）。 焊料凸点互连（16）跨越间隙（22）延伸并连接集成电路管芯（12）和衬底（14）。 模具（30）围绕预组件（18）设置，使得模具（30）与衬底（14）配合以限定围绕集成电路管芯（12）的模腔（32）。 模具（30）具有包括周围区域（28）的模制表面（34）和面向背面（24）并与其间隔开的模具表面（34）。 聚合物前体（36）被分配到模腔（32）中并且抵靠模制表面（34）和背面（24）形成。 聚合物前体（36）然后被固化以形成封装集成电路管芯（12）的聚合密封剂（38）。

公开(公告)号：US5835700A

公开(公告)日：1998-11-10

申请号：US698951

申请日：1996-08-16

申请人： Guy A. Carbonneau ,  Bernie Wu ,  Tim Jones

发明人： Guy A. Carbonneau ,  Bernie Wu ,  Tim Jones

IPC分类号： G06F1/26 ,  G06F3/06 ,  G06F11/267 ,  G06F11/30 ,  G06F11/34 ,  G06F13/00 ,  G06F21/00

CPC分类号： G06F3/0614 ,  G06F11/3034 ,  G06F11/3048 ,  G06F11/3058 ,  G06F21/86 ,  G06F3/0607 ,  G06F3/0653 ,  G06F3/0689 ,  G06F11/221 ,  G06F11/3485 ,  G06F11/349

摘要： An intelligent status monitoring, reporting and control module is coupled to a SCSI bus that interconnects a cluster of SCSI-compatible data storage modules (e.g., magnetic disk drives). The status monitoring, reporting and control module is otherwise coupled to the cluster of SCSI-compatible data storage modules and to power maintenance and/or other maintenance subsystems of the cluster for monitoring and controlling states of the data storage modules and power maintenance and/or other maintenance subsystems that are not readily monitored or controlled directly by way of the SCSI bus. The status monitoring, reporting and control module sends status reports to a local or remote system supervisor and executes control commands supplied by the local or remote system supervisor. The status reports include reports about system temperature and power conditions. The executable commands include commands for regulating system temperature and power conditions.

公开(公告)号：US5586250A

公开(公告)日：1996-12-17

申请号：US151525

申请日：1993-11-12

申请人： Guy A. Carbonneau ,  Bernie Wu ,  Tim Jones

发明人： Guy A. Carbonneau ,  Bernie Wu ,  Tim Jones

IPC分类号： G06F1/26 ,  G06F3/06 ,  G06F11/267 ,  G06F11/30 ,  G06F11/34 ,  G06F13/00 ,  G06F21/00 ,  G06F11/00

CPC分类号： G06F3/0614 ,  G06F11/3034 ,  G06F11/3048 ,  G06F11/3058 ,  G06F21/86 ,  G06F3/0607 ,  G06F3/0653 ,  G06F3/0689 ,  G06F11/221 ,  G06F11/3485 ,  G06F11/349

摘要： An intelligent status monitoring, reporting and control module is coupled to a SCSI bus that interconnects a cluster of SCSI-compatible data storage modules (e.g., magnetic disk drives). The status monitoring, reporting and control module is otherwise coupled to the cluster of SCSI-compatible data storage modules and to power maintenance and/or other maintenance subsystems of the cluster for monitoring and controlling states of the data storage modules and power maintenance and/or other maintenance subsystems that are not readily monitored or controlled directly by way of the SCSI bus. The status monitoring, reporting and control module sends status reports to a local or remote system supervisor and executes control commands supplied by the local or remote system supervisor. The status reports include reports about system temperature and power conditions. The executable commands include commands for regulating system temperature and power conditions.