公开(公告)号：US20230265159A1

公开(公告)日：2023-08-24

申请号：US18192274

申请日：2023-03-29

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth GIFFORD ,  Brandon CARTER

IPC: C07K14/74 ,  G01N33/569 ,  G16B20/30 ,  G16B5/20 ,  G16B30/00 ,  G16B20/40 ,  G16B35/10 ,  G16B15/20 ,  A61K39/00 ,  G16B5/00

CPC classification number: C07K14/70539 ,  G01N33/56977 ,  G16B20/30 ,  G16B5/20 ,  G16B30/00 ,  G16B20/40 ,  G16B35/10 ,  G16B15/20 ,  A61K39/0011 ,  G16B5/00 ,  A61K38/00

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US11672850B2

公开(公告)日：2023-06-13

申请号：US17729290

申请日：2022-04-26

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61K38/10 ,  A61K38/08 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/06 ,  C07K7/08 ,  A61P35/00 ,  A61K48/00

CPC classification number: A61K39/00116 ,  A61K38/08 ,  A61K38/10 ,  A61K39/001152 ,  A61K39/001158 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K48/00 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/86

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.

公开(公告)号：US11421015B2

公开(公告)日：2022-08-23

申请号：US17389875

申请日：2021-07-30

Applicant: Think Therapeutics, Inc.

Inventor： David Gifford ,  Brandon Carter

IPC: C07K14/74 ,  G01N33/569 ,  G16B20/30 ,  G16B5/20 ,  G16B30/00 ,  G16B20/40 ,  G16B35/10 ,  G16B15/20 ,  A61K39/00 ,  G16B5/00 ,  A61K38/00

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US20240383963A1

公开(公告)日：2024-11-21

申请号：US18793638

申请日：2024-08-02

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth GIFFORD ,  Brandon CARTER

IPC: C07K14/74 ,  A61K38/00 ,  A61K39/00 ,  G01N33/569 ,  G16B5/00 ,  G16B5/20 ,  G16B15/20 ,  G16B20/30 ,  G16B20/40 ,  G16B30/00 ,  G16B35/10

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US12091443B2

公开(公告)日：2024-09-17

申请号：US18192274

申请日：2023-03-29

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61K38/17 ,  C07K14/435 ,  C07K14/74 ,  G01N33/569 ,  G16B5/00 ,  G16B5/20 ,  G16B15/20 ,  G16B20/30 ,  G16B20/40 ,  G16B30/00 ,  G16B35/10

CPC classification number: C07K14/70539 ,  A61K39/0011 ,  G01N33/56977 ,  G16B5/00 ,  G16B5/20 ,  G16B15/20 ,  G16B20/30 ,  G16B20/40 ,  G16B30/00 ,  G16B35/10 ,  A61K38/00

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US11464842B1

公开(公告)日：2022-10-11

申请号：US17243096

申请日：2021-04-28

Applicant: Think Therapeutics, Inc.

Inventor： David Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61P35/00 ,  A61K38/10 ,  A61K38/08 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/06 ,  C07K7/08 ,  A61K48/00

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.

公开(公告)号：US20220177543A1

公开(公告)日：2022-06-09

申请号：US17389875

申请日：2021-07-30

Applicant: Think Therapeutics, Inc.

Inventor： David GIFFORD ,  Brandon CARTER

IPC: C07K14/74 ,  G16B20/30 ,  A61K39/00 ,  G16B35/10 ,  G16B5/00 ,  G16B5/20 ,  G16B30/00 ,  G16B20/40 ,  G01N33/569 ,  G16B15/20

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US11161892B1

公开(公告)日：2021-11-02

申请号：US17114237

申请日：2020-12-07

Applicant: Think Therapeutics, Inc.

Inventor： David Gifford ,  Brandon Carter

IPC: C07K14/74 ,  G01N33/569 ,  A61K39/00 ,  G16B20/30 ,  G16B30/00 ,  G16B35/10 ,  G16B20/40 ,  G16B5/20 ,  G16B15/20 ,  G16B5/00 ,  A61K38/00

Abstract: A system for selecting an immunogenic peptide composition comprising a processor and a memory storing processor-executable instructions that, when executed by the processor, cause the processor to create a first peptide set by selecting a plurality of base peptides, wherein at least one peptide of the plurality of base peptides is associated with a disease, create a second peptide set by adding to the first peptide set a modified peptide, wherein the modified peptide comprises a substitution of at least one residue of a base peptide selected from the plurality of base peptides, and create a third peptide set by selecting a subset of the second peptide set, wherein the selected subset of the second peptide set has a predicted vaccine performance, wherein the predicted vaccine performance has a population coverage above a predetermined threshold, and wherein the subset comprises at least one peptide of the second peptide set.

公开(公告)号：US12064475B2

公开(公告)日：2024-08-20

申请号：US18170994

申请日：2023-02-17

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K38/10 ,  A61P35/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/00 ,  C07K17/00 ,  A61K48/00

CPC classification number: A61K39/00116 ,  A61K38/08 ,  A61K38/10 ,  A61K39/001152 ,  A61K39/001158 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/86 ,  A61K48/00

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.

公开(公告)号：US20240269250A1

公开(公告)日：2024-08-15

申请号：US18438740

申请日：2024-02-12

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth GIFFORD ,  Brandon CARTER

IPC: A61K39/00 ,  C12Q1/6886

CPC classification number: A61K39/001111 ,  C12Q1/6886 ,  C12Q2600/106

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 154 to 191 or selected from the group consisting of SEQ ID NOs: 203 to 213 for administration in a subject that has two or more HLA alleles selected from A0201, A0202, A0203, A0204, A0205, A0206, A0207, A0211, A0214, A02264, A0230, A0301, A0302, A0305, A1101, A1102, A3001, A3002, A3004, A3009, A3101, A3104, A3303, A3401, A3402, A3601, A6601, A6602, A6603, A6801, A6802, A6827, A6901, A74, A7401, A7402, A7403, A7404, A7405, A7406, A7407, A7408, A7409, A7410, A7411, A7413, B0702, B0705, B2705, B4201, B4202, B5401, B5501, B5502, B5601, B5604, B5610, B5703, C0102, C0103, C0144, C0202, C0210, C0214, C0229, C0302, C0303, C0304, C0305, C0317, C0403, C0404, C0501, C0509, C0602, C0702, C0704, C0705, C0801, C0802, C0803, C0804, C0812, C1202, C1203, C1502, C1504, C1505, C1509, C1601, C1602, C1604, C16112, C1646, C17, C1701, C1702, C1703, C1704, C1705, C1706, and C1707.