公开(公告)号：US20230364212A1

公开(公告)日：2023-11-16

申请号：US18170994

申请日：2023-02-17

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth GIFFORD ,  Brandon CARTER

IPC: A61K39/00 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  A61P35/00

CPC classification number: A61K39/00116 ,  A61K38/08 ,  A61K38/10 ,  A61K39/001152 ,  A61K39/001158 ,  C07K7/06 ,  C07K7/08 ,  A61P35/00 ,  A61K2039/86 ,  A61K48/00

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.

公开(公告)号：US20230190902A1

公开(公告)日：2023-06-22

申请号：US17926188

申请日：2021-05-28

Applicant: Children's National Medical Center

Inventor： Catherine Mary Bollard ,  Patrick Hanley ,  Conrad Russell Y. Cruz ,  Maja Stanojevic ,  Amy Hont

IPC: A61K39/00 ,  A61K39/39 ,  A61P35/00

CPC classification number: A61K39/001189 ,  A61K39/39 ,  A61K39/001186 ,  A61K39/001188 ,  A61K39/001182 ,  A61K39/00116 ,  A61K39/001151 ,  A61K39/001194 ,  A61K39/001152 ,  A61K39/001192 ,  A61K39/001184 ,  A61K39/001164 ,  A61P35/00 ,  A61K2039/5158 ,  A61K2039/55561 ,  A61K2039/55516 ,  A61K2039/55533 ,  A61K2039/55538 ,  A61K2039/55527

Abstract: The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.

公开(公告)号：US11672850B2

公开(公告)日：2023-06-13

申请号：US17729290

申请日：2022-04-26

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61K38/10 ,  A61K38/08 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/06 ,  C07K7/08 ,  A61P35/00 ,  A61K48/00

CPC classification number: A61K39/00116 ,  A61K38/08 ,  A61K38/10 ,  A61K39/001152 ,  A61K39/001158 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K48/00 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/86

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.

公开(公告)号：US20240075116A1

公开(公告)日：2024-03-07

申请号：US18183082

申请日：2023-03-13

Applicant: CureVac SE

Inventor： Mariola FOTIN-MLECZEK ,  Ingmar HOERR

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K39/001103 ,  A61K39/001104 ,  A61K39/001106 ,  A61K39/001107 ,  A61K39/001109 ,  A61K39/001119 ,  A61K39/001122 ,  A61K39/001139 ,  A61K39/00114 ,  A61K39/00115 ,  A61K39/001151 ,  A61K39/001156 ,  A61K39/001157 ,  A61K39/001158 ,  A61K39/00116 ,  A61K39/001162 ,  A61K39/001166 ,  A61K39/001168 ,  A61K39/001182 ,  A61K39/001184 ,  A61K39/001186 ,  A61K39/001188 ,  A61K39/00119 ,  A61K39/001191 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/001195 ,  A61P35/00 ,  A61K2039/53

Abstract: The present invention relates to an RNA encoding a tumor antigen. In particular, the present invention relates to RNA suitable for treatment and/or prophylaxis of cancer and related diseases. The present invention concerns such RNA as well as compositions, vaccines and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions, vaccines or kits as disclosed herein for use in the treatment and/or prophylaxis of cancer and related diseases.

公开(公告)号：US12064475B2

公开(公告)日：2024-08-20

申请号：US18170994

申请日：2023-02-17

Applicant: Think Therapeutics, Inc.

Inventor： David Kenneth Gifford ,  Brandon Carter

IPC: A61K39/00 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K38/10 ,  A61P35/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/00 ,  C07K17/00 ,  A61K48/00

CPC classification number: A61K39/00116 ,  A61K38/08 ,  A61K38/10 ,  A61K39/001152 ,  A61K39/001158 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/86 ,  A61K48/00

Abstract: Described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 19 to 50. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 141 to 272. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 273 to 322. Also described herein is an immunogenic composition comprising nucleic acid sequences encoding two or more amino acid sequences selected from the group consisting of SEQ ID NOs: 354 to 458.