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公开(公告)号：US09606245B1
公开(公告)日：2017-03-28
申请号：US15080073
申请日：2016-03-24
申请人： The Research Foundation for The State University of New York , The Research Foundation for The State University of New York , Memorial Sloan Kettering Cancer Center , Cornell University , University of South Carolina
发明人： Steve Czarnecki , Andrzej Krol , Krishna Mandal , Mark D. Poliks , C. Ross Schmidtlein , Michael Thompson , James Turner
IPC分类号： G01T1/20
CPC分类号： G01T1/208 , A61B6/037 , A61B6/501 , G01T1/1642 , G01T1/2006 , G01T1/2018 , G01T1/245
摘要： A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.
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公开(公告)号：US09835737B1
公开(公告)日：2017-12-05
申请号：US15468968
申请日：2017-03-24
申请人： The Research Foundation for The State University of New York , The Research Foundation for The State University of New York , Memorial Sloan Kettering Cancer Center , Cornell University , University of South Carolina
发明人： Steve Czarnecki , Andrzej Krol , Krishna Mandal , Mark D. Poliks , C. Ross Schmidtlein , Michael Thompson , James Turner
CPC分类号： G01T1/208 , A61B6/037 , A61B6/501 , G01T1/1642 , G01T1/2006 , G01T1/2018 , G01T1/245
摘要： A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.
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公开(公告)号：US20240339593A1
公开(公告)日：2024-10-10
申请号：US18627394
申请日：2024-04-04
CPC分类号： H01M4/364 , C25B11/091 , H01G11/36 , H01M4/5815 , H01M4/587 , H01M4/8652 , H01M4/90 , H01M2004/027 , H01M2004/8684
摘要： Nanohybrid composites, methods of making nanohybrid composites, and uses of nanohybrid composites. A nanohybrid composite may be a binary nanohybrid composite comprising MXene and dual-phase MoS2. A nanohybrid composite may be a ternary nanohybrid composite comprising MXene, dual-phase MoS2, and a plurality of carbon nanotubes. A nanohybrid composite may be made by a method comprising contacting a liquid or liquid(s), a MXene or MXenes, a sulfur precursor or sulfur precursors, a molybdenum precursor or molybdenum precursors, optionally, an ammonium precursor or ammonium precursors, and, optionally, carbon nanotubes to form a reaction mixture; heating the reaction mixture, where the nanohybrid composite is formed. Anodes may comprise one or more nanohybrid composite(s). Devices, such as, for example, batteries or the like, may comprise one or more anode(s) comprising one or more nanohybrid composite(s) and/or one or more nanohybrid composite(s).
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公开(公告)号：US20240316501A1
公开(公告)日：2024-09-26
申请号：US18680523
申请日：2024-05-31
发明人： Matthew EISAMAN
IPC分类号： B01D61/44 , B01D61/46 , C02F1/44 , C02F1/461 , C02F1/469 , C02F1/66 , C02F103/06 , C02F103/10
CPC分类号： B01D61/445 , B01D61/46 , C02F1/4618 , C02F1/4693 , C02F1/66 , B01D2311/18 , B01D2313/143 , B01D2313/146 , B01D2317/02 , C02F1/441 , C02F2001/4619 , C02F2103/06 , C02F2103/10 , C02F2201/46115 , C02F2201/46145 , C02F2301/08
摘要： The disclosure relates to enhancing alkalinity of brine, e.g. seawater, using bipolar membrane electrodialysis (BPMED) without removing divalent cations that otherwise cause scaling. In one embodiment, a BPMED is employed wherein the brine volumetric flow rate through a basification compartment is greater at a given current density than that through a brine compartment which increases the pH of the brine output while keeping it below the precipitation pH. In one embodiment, the spacer located in the basification compartment is thicker than spacers elsewhere in the BPMED so as resist membrane distortion due to the increased hydrostatic pressure in the basification compartment given the greater volumetric flow. The brine output having increased alkalinity can be returned to the ocean to mitigate acidification and enable capture of atmospheric carbon dioxide.
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公开(公告)号：US20240310321A1
公开(公告)日：2024-09-19
申请号：US18575877
申请日：2022-07-01
IPC分类号： G01N27/414 , G01N27/416
CPC分类号： G01N27/4148 , G01N27/4167
摘要： A pHI sensor system, Integrated Circuit (IC) chip, and a method are provided. Embodiments of the pH sensor may a first p-channel ion-sensitive transistor (IST)-operational-transconductance-amplifier (PIOTA) and a second PIOTA. Each PIOTA may further include a p-channel IST, an n-channel load transistor having a source and drain, wherein each PIOTA may have a drain-to-source resistance different from each other. Each PIOTA may further include an operational-transconductance-amplifier (OTA). A differential sensor may be connected to the outputs of both PIOTAs, and an output from the differential sensor may indicate a change in pH. Each PIOTA may further have an n-type substrate, a potential of which may be varied to control sensitivity of pH change detection. The NMOS load transistors of one or both of the PIOTAs may be selected from a plurality of NMOS load transistors to enhance sensitivity.
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6.发明公开公开(公告)号：US20240296961A1
公开(公告)日：2024-09-05
申请号：US18569431
申请日：2022-06-13
发明人： Janet L Paluh , Rounak Chatterjee , Soham Mondal , Souradeep Chowdhury , Arnab Raha , Amitava Mukherjee
摘要： A system and method for modeling neuronal synaptic functionality at least partially instantiated on an optimized computation core of one or more high-speed processors. The synaptic model is preferably created as a neural net and includes, at least, a presynaptic component with a presynaptic target having, at least, a plasticity parameter and activity spike strength. The model also includes a retrograde signaling component with a retrograde messenger that selectively generates a molecular uptake signal, and a postsynaptic receptor component. The retrograde messenger acts on a presynaptic target to modulate the plasticity parameter and activity spike strength of the presynaptic component based upon a calculated molecular uptake at the postsynaptic receptor component to generate the molecular uptake signal which is then transmitted to the presynaptic component.
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公开(公告)号：US12077795B2
公开(公告)日：2024-09-03
申请号：US16989843
申请日：2020-08-10
发明人： Brian Callahan , Timothy Owen
CPC分类号： C12P21/00 , A61K47/55 , A61K47/554 , C07K1/1077 , C12N9/1029 , C12Y201/01041
摘要： A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.
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8.发明授权公开(公告)号：US12060002B2
公开(公告)日：2024-08-13
申请号：US17605068
申请日：2020-04-24
发明人： Shan Lin
摘要： A system and method for monitoring and analyzing activities of a person operating a machine, particularly driving a vehicle, is provided. A first magnet is attached to a hand of the person and a second magnet is attached to the head of the person. A smart watch having a magnetometer is attached to the other hand of the person. The magnetometer is in magnetic communication with both the first magnet and the second magnet to generate a first magnetic signal and a second magnetic signal. Both signals can be received by a processor and applied to mathematical models by the processor to generate indicators representative of positions and motions of the hands and the head. An alarm can be generated based on the indicators.
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公开(公告)号：US12059413B2
公开(公告)日：2024-08-13
申请号：US16342695
申请日：2017-10-30
申请人： The Research Foundation for the State University of New York , THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
发明人： Carol Carter , Lorna Erlich , Nico Tjandra , Madeleine Davison
IPC分类号： A61K31/4439 , G01N33/569
CPC分类号： A61K31/4439 , G01N33/56988
摘要： The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.
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公开(公告)号：US12055392B2
公开(公告)日：2024-08-06
申请号：US17321154
申请日：2021-05-14
发明人： Alex Nikulin , Timothy S. De Smet
IPC分类号： G01C15/00 , B64C39/02 , B64U101/30 , G01S19/40 , G05D1/00
CPC分类号： G01C15/00 , B64C39/024 , G01S19/40 , G05D1/106 , B64U2101/30
摘要： There are approximately 35,000 abandoned and unplugged oil and gas wells in New York with no known location. Unplugged wells emit methane, a strong greenhouse gas, which has the potential to significantly contribute to global climate change and act as a pollutant chemical. A long-range UAV equipped with methane sensors, MagPike (atomic magnetometer), and LiDAR sensors successfully detected unmarked well sites using characteristic magnetic signals generated by vertical metal piping preserved in the ground. The optimal flight altitude and transect spacing was determined for detection driven by the total field strength of the Earth's magnetic field and the height of tree canopies determined by LiDAR. Traditional methods of identifying oil and gas wells are costly and less powerful in acquisition of data such as using large magnetometers attached to helicopters.
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