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    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
    4.
    发明申请
    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
    2-PHENYL-INDOLES作为PROSTAGLANDIN D2受体拮抗剂

    公开(公告)号：US20070265278A1

    公开(公告)日：2007-11-15

    申请号：US11782890

    申请日：2007-07-25

    Applicant: Keith HARRIS ,  Hans-Jochen Lang ,  Rose Mathew ,  Stephen Shimshock ,  Thaddeus Nieduzak ,  Sharon Jackson ,  Zhaoxia Yang ,  Kenneth Bordeau

    Inventor： Keith HARRIS ,  Hans-Jochen Lang ,  Rose Mathew ,  Stephen Shimshock ,  Thaddeus Nieduzak ,  Sharon Jackson ,  Zhaoxia Yang ,  Kenneth Bordeau

    IPC: A61K31/404 ,  A61K31/4245 ,  A61K31/435 ,  A61K31/4453 ,  A61K31/47 ,  A61K31/495 ,  A61P1/04 ,  A61P37/08 ,  A61P9/00 ,  C07D209/04 ,  C07D271/113 ,  C07D401/12

    CPC classification number: C07D209/12 ,  C07D209/18 ,  C07D209/22 ,  C07D209/24 ,  C07D405/12 ,  C07D413/06

    Abstract: The present invention is directed to a compound of Formula (XVI): (please replace Formula (I) with Formula (XVI) as shown below) wherein R, R2, R3, R4, R5, R6, R7 and n are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmaceutically acceptable salt, hydrate or solvate of the prodrug, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (XVI) in admixture with a pharmaceutically acceptable carrier, a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (XVI).

    Abstract translation: 本发明涉及式（ⅩⅥ）化合物：（如下所示，用式（ⅩⅥ）表示的式（I）表示）其中R，R 2，R 3， R 4，R 4，R 5，R 6，R 7和n如本文所定义，或 其药学上可接受的盐，水合物或溶剂化物，其药学上可接受的前药，或药学上可接受的盐，水合物或溶剂化物，药物组合物，其包含药学上有效量的根据式（XVI）的一种或多种化合物 与药学上可接受的载体混合，治疗患有PGD2介导的病症的患者的方法，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），全身肥大细胞增多症 ，伴有系统性肥大细胞活化，过敏性休克，支气管收缩，支气管炎，荨麻疹， 湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），伴随瘙痒的行为（如刮伤和殴打）而产生的疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍） ，炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（XVI）的化合物。

    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
    6.
    发明申请
    2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
    2-PHENYL-INDOLES作为PROSTAGLANDIN D2受体拮抗剂

    公开(公告)号：US20090176804A1

    公开(公告)日：2009-07-09

    申请号：US12357725

    申请日：2009-01-22

    Applicant: Zhaoxia YANG ,  Stephan REILING ,  Thaddeus NIEDUZAK ,  Rose M. MATHEW ,  Sharon JACKSON ,  Keith John HARRIS

    Inventor： Zhaoxia YANG ,  Stephan REILING ,  Thaddeus NIEDUZAK ,  Rose M. MATHEW ,  Sharon JACKSON ,  Keith John HARRIS

    IPC: A61K31/404 ,  C07D209/18 ,  C07D209/20 ,  C07D257/06 ,  A61K31/41 ,  A61P17/00 ,  A61P37/08 ,  A61K31/496 ,  A61K31/435

    CPC classification number: C07D209/18

    Abstract: The present invention is directed to 2-phenyl-indole compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, eczema, urticaria diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

    Abstract translation: 本发明涉及2-苯基 - 吲哚化合物，其制备方法，含有这些化合物的药物组合物及其在治疗患有PGD2介导的病症的患者中的药物用途，包括但不限于过敏性疾病（如过敏性疾病 鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），全身肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏性休克，支气管收缩，支气管炎，湿疹，伴有瘙痒的荨麻疹（如特应性皮炎和荨麻疹） （如白内障，视网膜脱离，炎症，感染和睡眠障碍），其由于伴随瘙痒的行为（例如划伤和打浆），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性 类风湿性关节炎，胸膜炎，溃疡性结肠炎等。

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