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公开(公告)号:US20110300129A1
公开(公告)日:2011-12-08
申请号:US13139220
申请日:2009-12-14
IPC分类号: A61K39/395 , A61P39/00 , C12N5/078 , A61P31/04 , A61K39/02 , A61P37/04 , A61P31/12 , A61P33/00 , A61K45/06 , A61K39/12
CPC分类号: A61K31/195 , A61K31/20 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/5258 , A61K2039/55561 , C12N5/0635 , C12N2501/056 , C12N2501/385 , C12N2710/20023 , C12N2710/20034
摘要: Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed are methods of inducing B cell differentiation and promoting an immune response against an antigen.
摘要翻译: 本发明的药物组合物包括编码抗原的抗原或核酸分子; 一个或两个PPAR配体和RxR配体; 和药学上合适的载体。 药物组合物可任选地包括丝裂原或其它添加剂。 还公开了诱导B细胞分化并促进针对抗原的免疫应答的方法。