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公开(公告)号：USD665904S1
公开(公告)日：2012-08-21
申请号：US29378994
申请日：2010-11-12
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公开(公告)号：US09039664B2
公开(公告)日：2015-05-26
申请号：US14112092
申请日：2012-04-16
CPC分类号： A61M5/2466 , A61M5/2429 , A61M5/315 , A61M5/31511 , A61M5/31513 , A61M2207/00 , B01L3/50825
摘要： In a prefilled syringe including an elastic seal member to be pierced with a needle for use to eject a protein pharmaceutical preparation therefrom, the elastic seal member ensures smooth and reliable piercing thereof with the needle while reliably preventing an active substance of the protein pharmaceutical preparation from being adsorbed thereon. When a protective film (3) is laminated to a top surface of a seal body (2) of an elastic material, the protective film (3) is stretched to a greater extent by a recess (4) provided in the top surface. Further, the piercing portion to be pierced with the needle is provided in a bottom of the recess (4). Thus, the protective film (3) is formed as locally having a smaller thickness in the piercing portion.
摘要翻译： 在包括弹性密封构件的预充式注射器中，所述弹性密封构件用用于从其中排出蛋白质药物制剂的针刺穿，弹性密封构件确保使用针的平滑可靠的刺穿，同时可靠地防止蛋白质药物制剂的活性物质 被吸附在其上。 当将保护膜（3）层压到弹性材料的密封体（2）的顶表面上时，保护膜（3）通过设置在顶表面中的凹部（4）被更大程度地拉伸。 此外，在凹部（4）的底部设置有用刺针穿刺的部分。 因此，保护膜（3）在穿孔部分局部形成为较小的厚度。
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公开(公告)号：US20140066859A1
公开(公告)日：2014-03-06
申请号：US14112092
申请日：2012-04-16
IPC分类号： A61M5/24
CPC分类号： A61M5/2466 , A61M5/2429 , A61M5/315 , A61M5/31511 , A61M5/31513 , A61M2207/00 , B01L3/50825
摘要： In a prefilled syringe including an elastic seal member to be pierced with a needle for use to eject a protein pharmaceutical preparation therefrom, the elastic seal member ensures smooth and reliable piercing thereof with the needle while reliably preventing an active substance of the protein pharmaceutical preparation from being adsorbed thereon. When a protective film (3) is laminated to a top surface of a seal body (2) of an elastic material, the protective film (3) is stretched to a greater extent by a recess (4) provided in the top surface. Further, the piercing portion to be pierced with the needle is provided in a bottom of the recess (4). Thus, the protective film (3) is formed as locally having a smaller thickness in the piercing portion.
摘要翻译： 在包括弹性密封构件的预充式注射器中，所述弹性密封构件用用于从其中排出蛋白质药物制剂的针刺穿，弹性密封构件确保使用针的平滑可靠的刺穿，同时可靠地防止蛋白质药物制剂的活性物质 被吸附在其上。 当将保护膜（3）层压到弹性材料的密封体（2）的顶表面上时，保护膜（3）通过设置在顶表面中的凹部（4）被更大程度地拉伸。 此外，在凹部（4）的底部设置有用刺针穿刺的部分。 因此，保护膜（3）在穿孔部分局部形成为较小的厚度。
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公开(公告)号：US08529519B2
公开(公告)日：2013-09-10
申请号：US12935638
申请日：2009-03-30
申请人： Mitsuru Hasegawa , Taiji Horita
发明人： Mitsuru Hasegawa , Taiji Horita
IPC分类号： A61M5/32
CPC分类号： A61M5/28 , A61M5/347 , A61M2005/3104
摘要： Provided is a tight-sealing cap for the liquid drug-expelling part of a syringe that not only minimizes the space that creates reduced pressure, which is a cause of leakage, but is also easy to remove because it is easily twisted off, easily deformable and easily admits air for releasing the vacuum when removed, and that can prevent leaking of a liquid drug from a luer nozzle. The cap is made of an elastic material, and the following means are used in the cap, which is configured from a thick upper surface part, an outer tubular part that is formed below the periphery thereof, and an inner tubular part that is formed inside the same. First, the inner tubular part is formed so that the tip of the luer nozzle can be inserted tightly into the same, and the luer nozzle can be tightly sealed at the site of contact thereof. Second, the outer tubular part is formed so that it contacts the luer lock closely therein and can seal the luer lock tightly at the site of contact thereof. Third, the length of the site of contact between the outer tubular part and the luer lock is shorter than the length of the site of contact between the inner tubular part and the luer nozzle.
摘要翻译： 提供了一种用于注射器的液体药物排出部分的紧密封盖，其不仅使产生减压的空间最小化，这是造成泄漏的原因，而且容易被去除，容易变形 并且容易地承认在去除时释放真空的空气，并且可以防止液体药物从鲁尔喷嘴泄漏。 帽由弹性材料制成，并且在帽中使用以下装置，其由较厚的上表面部分，形成在其周边的外部管状部分和内部管状部分形成在内部 一样。 首先，内管状部分形成为能够将鲁尔喷嘴的尖端紧密地插入其中，并且可以在其接触部位紧密地密封鲁尔喷嘴。 第二，外管状部分形成为使得其紧密地接触鲁尔锁，并且可以在其接触部位处紧密地密封鲁尔锁。 第三，外部管状部件和鲁尔锁定件之间的接触部位的长度短于内部管状部件和鲁尔喷嘴之间的接触部位的长度。
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公开(公告)号：US20140025017A1
公开(公告)日：2014-01-23
申请号：US14009582
申请日：2011-04-20
申请人： Taiji Horita , Norihiko Asahi , Ippei Matsumoto , Kensuke Taniguchi , Takeshi Karasawa , Akemi Sasaki
发明人： Taiji Horita , Norihiko Asahi , Ippei Matsumoto , Kensuke Taniguchi , Takeshi Karasawa , Akemi Sasaki
IPC分类号： A61M5/34
CPC分类号： A61M5/344 , A61M5/347 , A61M2005/3104
摘要： The present invention provides a barrel with a cap, a pre-filled syringe, and a cap with a connector that are available for both connection-receiving bodies of the Luer lock type and connection-receiving bodies of the slip-in type. The present invention is characterized by including: a connector (3) that is detachably coupled to a cap (2) so as to be separated from the barrel (1) together with the cap (2) when the connector (3) is located at an initial position where the connector (3) is attached to a barrel (1) via the cap (2); and a connector-side engaging part 33 that engages a barrel-side engaging part (13) of the barrel (1) when the connector (3) is located at an attached position that is located closer to a proximal end in an axial direction of the barrel (1) than the initial position is, thereby allowing the connector (3) to remain attached to the barrel (1) by being detached from the cap (2) separated from a nozzle (11).
摘要翻译： 本发明提供一种具有盖，预填充注射器和具有连接器的盖，其可用于Luer锁式连接接收体和滑入式连接接收体两者。 本发明的特征在于包括：连接器（3），其可拆卸地联接到帽（2），以便当连接器（3）位于（1）处时，与盖（2）一起与盖 连接器（3）经由盖（2）附接到枪管（1）的初始位置; 以及连接器侧接合部33，其在所述连接器（3）位于所述连接器（3）位于更靠近基端的安装位置时与所述筒体（1）的筒体侧接合部（13）接合， 桶（1）比起初始位置为止，从而允许连接器（3）通过从与喷嘴（11）分离的盖（2）分离而保持附接到筒体（1）。
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公开(公告)号：US20110139830A1
公开(公告)日：2011-06-16
申请号：US12935638
申请日：2009-03-30
申请人： Mitsuru Hasegawa , Taiji Horita
发明人： Mitsuru Hasegawa , Taiji Horita
IPC分类号： B65D47/00
CPC分类号： A61M5/28 , A61M5/347 , A61M2005/3104
摘要： Provided is a tight-sealing cap for the liquid drug-expelling part of a syringe that not only minimizes the space that creates reduced pressure, which is a cause of leakage, but is also easy to remove because it is easily twisted off, easily deformable and easily admits air for releasing the vacuum when removed, and that can prevent leaking of a liquid drug from a luer nozzle. The cap is made of an elastic material, and the following means are used in the cap, which is configured from a thick upper surface part, an outer tubular part that is formed below the periphery thereof, and an inner tubular part that is formed inside the same. First, the inner tubular part is formed so that the tip of the luer nozzle can be inserted tightly into the same, and the luer nozzle can be tightly sealed at the site of contact thereof. Second, the outer tubular part is formed so that it contacts the luer lock closely therein and can seal the luer lock tightly at the site of contact thereof. Third, the length of the site of contact between the outer tubular part and the luer lock is shorter than the length of the site of contact between the inner tubular part and the luer nozzle.
摘要翻译： 提供了一种用于注射器的液体药物排出部分的紧密封盖，其不仅使产生减压的空间最小化，这是造成泄漏的原因，而且容易被去除，容易变形 并且容易地承认在去除时释放真空的空气，并且可以防止液体药物从鲁尔喷嘴泄漏。 帽由弹性材料制成，并且在帽中使用以下装置，其由较厚的上表面部分，形成在其周边的外部管状部分和内部管状部分形成在内部 一样。 首先，内管状部分形成为能够将鲁尔喷嘴的尖端紧密地插入其中，并且可以在其接触部位紧密地密封鲁尔喷嘴。 第二，外管状部分形成为使得其紧密地接触鲁尔锁，并且可以在其接触部位处紧密地密封鲁尔锁。 第三，外部管状部件和鲁尔锁定件之间的接触部位的长度短于内部管状部件和鲁尔喷嘴之间的接触部位的长度。
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公开(公告)号：US07935078B2
公开(公告)日：2011-05-03
申请号：US11666656
申请日：2006-01-27
申请人： Taiji Horita , Ippei Matsumoto
发明人： Taiji Horita , Ippei Matsumoto
摘要： A multi-chamber syringe 10 which can be manufactured at a low-cost and high-productivity is provided. The syringe 10 includes a generally cylindrical barrel 12, a push member 14 and a plug 16, both of which are disposed to fit the inner side surface 12a of the barrel 12 and slidably on the inner side surface 12a. The plug 16 has a main surface 16a provided with a projection 34 having a top 34a which is eccentric to the main surface 16a. When the push member 14 slides in the direction indicated by Arrow A, the plug 16 comes under pressure from the side on the open end 18. When the projection 34 of the projection 16 makes contact with the choked end 20, the pressure from the side on the open end 18 acts to turn the plug 16 in the direction indicated by Arrow B. This causes a bending deformation in a main body 30 and flanges 32a, 32b of the plug 16, to form a first gap 38 and a second gap 40 between the inner side surface 12a of the barrel 12 and the plug 16.
摘要翻译： 提供了可以以低成本和高生产率制造的多室注射器10。 注射器10包括大致圆柱形的筒体12，推动构件14和塞子16，两者都设置成配合筒体12的内侧表面12a并可滑动地位于内侧表面12a上。 插头16具有设置有突出部34的主表面16a，该突起34具有偏心于主表面16a的顶部34a。 当推动构件14沿着箭头A所示的方向滑动时，插头16从开口端18的一侧受到压力。当突起16的突起34与阻塞端20接触时，侧面的压力 在开口端18上作用是沿箭头B所示的方向转动插头16.这导致插头16的主体30和凸缘32a，32b的弯曲变形，形成第一间隙38和第二间隙40 在筒12的内侧表面12a和插头16之间。
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公开(公告)号：US20080215012A1
公开(公告)日：2008-09-04
申请号：US11666656
申请日：2006-01-27
申请人： Taiji Horita , Ippei Matsumoto
发明人： Taiji Horita , Ippei Matsumoto
IPC分类号： A61M5/19
摘要： A multi-chamber syringe 10 which can be manufactured at a low-cost and high-productivity is provided. The syringe 10 includes a generally cylindrical barrel 12, a push member 14 and a plug 16, both of which are disposed to fit the inner side surface 12a of the barrel 12 and slidably on the inner side surface 12a. The plug 16 has a main surface 16a provided with a projection 34 having a top 34a which is eccentric to the main surface 16a. When the push member 14 slides in the direction indicated by Arrow A, the plug 16 comes under pressure from the side on the open end 18. When the projection 34 of the projection 16 makes contact with the choked end 20, the pressure from the side on the open end 18 acts to turn the plug 16 in the direction indicated by Arrow B. This causes a bending deformation in a main body 30 and flanges 32a, 32b of the plug 16, to form a first gap 38 and a second gap 40 between the inner side surface 12a of the barrel 12 and the plug 16.
摘要翻译： 提供了可以以低成本和高生产率制造的多室注射器10。 注射器10包括大致圆柱形的镜筒12，推动构件14和插头16，两者都设置成配合到镜筒12的内侧表面12a并可滑动地位于内侧表面12a上。 插头16具有主表面16a，该主表面设置有具有顶部34a的突出部34，顶部34a偏离主表面16a。 当推动构件14沿箭头A所示的方向滑动时，插头16从开口端18的一侧受到压力。 当突起16的突起34与阻塞端20接触时，来自开口端18侧的压力用于沿着箭头B所示的方向转动插头16.这导致主体30中的弯曲变形 和插头16的凸缘32a，32b，以在筒12的内侧表面12a和插头16之间形成第一间隙38和第二间隙40。
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公开(公告)号：US6162200A
公开(公告)日：2000-12-19
申请号：US296345
申请日：1999-04-22
申请人： Teiichirou Sawa , Hirotaka Nishida , Taiji Horita
发明人： Teiichirou Sawa , Hirotaka Nishida , Taiji Horita
CPC分类号： A61M5/31513 , A61M2005/3104 , A61M2005/3131 , A61M2205/0222 , A61M2205/0238
摘要： The present invention provides a syringe including a tubular barrel. The tubular barrel has an open proximal end, a distal end with a fluid expelling passage defined therein, and a barrel chamber. A seal is disposed within the barrel chamber a predetermined distance away from the open proximal end in fluid-tight and axially-sliding engagement with the barrel chamber, so that fluid held in the barrel chamber between the fluid expelling passage and the seal can be expelled from the barrel chamber to the outside via the fluid expelling passage by sliding the seal towards the fluid expelling passage. The seal defines at least two diametrically enlarged portions at axially spaced apart portions of the seal so as to be respectively in abutment with the inner wall of the barrel chamber and a concave portion between adjacent diametrically enlarged portions of the at least two diametrically enlarged portions for defining a clearance relative to the inner wall of the barrel chamber, in which lubricant film exists at interfaces between the at least two diametrically enlarged portions of the seal and the inner wall of the barrel chamber, and lubricant is filled in the clearance. The present invention also provides a syringe assembly and an apparatus for manufacturing the syringe having the above arrangement.
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公开(公告)号：US09604012B2
公开(公告)日：2017-03-28
申请号：US14009582
申请日：2011-04-20
申请人： Taiji Horita , Norihiko Asahi , Ippei Matsumoto , Kensuke Taniguchi , Takeshi Karasawa , Akemi Sasaki
发明人： Taiji Horita , Norihiko Asahi , Ippei Matsumoto , Kensuke Taniguchi , Takeshi Karasawa , Akemi Sasaki
CPC分类号： A61M5/344 , A61M5/347 , A61M2005/3104
摘要： A barrel with a cap, a pre-filled syringe, and a cap with a connector that accommodate connection-receiving bodies of the Luer lock type and of the slip-in type, are provided. Some versions include: a connector (3) detachably coupled to a cap (2) so as to be separated from the barrel (1) together with the cap (2) when the connector (3) is located at an initial position where the connector (3) is attached to a barrel (1) via the cap (2); and a connector-side engaging part (33) that engages a barrel-side engaging part (13) of the barrel (1) when the connector (3) is located at an attached position that is closer to a proximal end in an axial direction of the barrel (1) than the initial position, allowing the connector (3) to remain attached to the barrel (1) by being detached from the cap (2) separated from a nozzle (11).
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