公开(公告)号：US20120302567A1

公开(公告)日：2012-11-29

申请号：US13575799

申请日：2011-01-28

Applicant: Seung Hyun Jung ,  Young Hee Jung ,  Wha Il Choi ,  Jung Beom Son ,  Eun Ju Jeon ,  In Ho Yang ,  Tae Hun Song ,  Mi Kyoung Lee ,  Myoung Sil Ko ,  Young Gil Ahn ,  Maeng Sup Kim ,  Young Jin Ham ,  Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Han ,  Dong-sik Park ,  Hwan Kim

Inventor： Seung Hyun Jung ,  Young Hee Jung ,  Wha Il Choi ,  Jung Beom Son ,  Eun Ju Jeon ,  In Ho Yang ,  Tae Hun Song ,  Mi Kyoung Lee ,  Myoung Sil Ko ,  Young Gil Ahn ,  Maeng Sup Kim ,  Young Jin Ham ,  Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Han ,  Dong-sik Park ,  Hwan Kim

IPC: A61K31/519 ,  A61P35/00 ,  C07D487/04 ,  C07D495/04 ,  A61K31/5377

CPC classification number: C07D495/04

Abstract: The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.

Abstract translation: 本发明涉及对蛋白激酶具有改善的抑制活性的新型双环杂芳基衍生物，其药学上可接受的盐，其水合物及其溶剂合物，以及用于预防或治疗异常细胞生长障碍的药物组合物， 活性成分。

公开(公告)号：US07112664B2

公开(公告)日：2006-09-26

申请号：US10726554

申请日：2003-12-04

Applicant: Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

Inventor： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

IPC: C07H21/02 ,  C07H21/00 ,  A61K39/42

CPC classification number: C07K16/082 ,  C07K2317/565

Abstract: The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatis B virus and a gene encoding the same, a recombinant vector containing the said gene, and a transformant obtained from the said recombinant vector.

公开(公告)号：US08476230B2

公开(公告)日：2013-07-02

申请号：US12523050

申请日：2008-01-04

Applicant: Dae Hae Song ,  Chang Ki Lim ,  Tae Hun Song ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Sung Youb Jung ,  In Young Choi

Inventor： Dae Hae Song ,  Chang Ki Lim ,  Tae Hun Song ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Sung Youb Jung ,  In Young Choi

IPC: A61K38/00 ,  A61K39/395 ,  A61P5/50

CPC classification number: C07K14/57563 ,  A61K38/00 ,  A61K47/6835 ,  C07K14/605

Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.

Abstract translation: 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和免疫球蛋白Fc区，并且使用它们 。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。

公开(公告)号：US20100105877A1

公开(公告)日：2010-04-29

申请号：US12523050

申请日：2008-01-04

Applicant: Dae Hae Song ,  Chang Ki Lim ,  Tae Hun Song ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Sung Youb Jung ,  In Young Choi

Inventor： Dae Hae Song ,  Chang Ki Lim ,  Tae Hun Song ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee ,  Sung Youb Jung ,  In Young Choi

IPC: C07K16/00

CPC classification number: C07K14/57563 ,  A61K38/00 ,  A61K47/6835 ,  C07K14/605

Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.

Abstract translation: 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和免疫球蛋白Fc区，并且使用它们 。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。

公开(公告)号：US06924368B2

公开(公告)日：2005-08-02

申请号：US10726555

申请日：2003-12-04

Applicant: Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

Inventor： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

IPC: C12N15/09 ,  C07K16/08 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04

CPC classification number: C07K16/082 ,  C07K2317/565

Abstract: The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatis B virus and a gene encoding the same, a recombinant vector containing the said gene, and a transformant obtained from the said recombinant vector.

Abstract translation: 本发明涉及针对乙型肝炎病毒的S表面抗原的单克隆抗体的可变区和编码该单克隆抗体的基因，含有该基因的重组载体和从所述重组载体获得的转化体。

公开(公告)号：US10112954B2

公开(公告)日：2018-10-30

申请号：US13575799

申请日：2011-01-28

Applicant: Seung Hyun Jung ,  Young Hee Jung ,  Wha Il Choi ,  Jung Beom Son ,  Eun Ju Jeon ,  In Ho Yang ,  Tae Hun Song ,  Mi Kyoung Lee ,  Myoung Sil Ko ,  Young Gil Ahn ,  Maeng Sup Kim ,  Young Jin Ham ,  Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Dong-sik Park ,  Hwan Kim

Inventor： Seung Hyun Jung ,  Young Hee Jung ,  Wha Il Choi ,  Jung Beom Son ,  Eun Ju Jeon ,  In Ho Yang ,  Tae Hun Song ,  Mi Kyoung Lee ,  Myoung Sil Ko ,  Young Gil Ahn ,  Maeng Sup Kim ,  Young Jin Ham ,  Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Dong-sik Park ,  Hwan Kim

IPC: C07D495/04 ,  A61K31/519 ,  A61P35/00 ,  A61P25/28 ,  A61P29/00 ,  A61P19/02

Abstract: The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.

公开(公告)号：US06680053B2

公开(公告)日：2004-01-20

申请号：US09865483

申请日：2001-05-29

Applicant: Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

Inventor： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Jung Hyun Nam ,  Moo Young Song ,  Hyung Jin Moon ,  Tae Hun Song

IPC: A61K3942

CPC classification number: C07K16/082 ,  C07K2317/565

Abstract: The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatis B virus and a gene encoding the same, a recombinant vector containing the said gene, and a transformant obtained from the said recombinant vector.

Abstract translation: 本发明涉及针对乙型肝炎病毒的S表面抗原的单克隆抗体的可变区和编码该抗体的基因，含有所述基因的重组载体和从所述重组载体获得的转化体。

公开(公告)号：US20090318375A1

公开(公告)日：2009-12-24

申请号：US11915929

申请日：2003-06-06

Applicant: Bo Sung Kwon ,  Eun Sook Kim ,  Hee Cheol Kim ,  Sangmin Yun ,  Myoung-sil Ko ,  Tae Hun Song ,  Han Kyong Kim ,  Kwee Hyun Suh ,  Gwansun Lee

Inventor： Bo Sung Kwon ,  Eun Sook Kim ,  Hee Cheol Kim ,  Sangmin Yun ,  Myoung-sil Ko ,  Tae Hun Song ,  Han Kyong Kim ,  Kwee Hyun Suh ,  Gwansun Lee

IPC: A61K31/7048 ,  C07H17/08 ,  A61P31/00

CPC classification number: C07H17/08

Abstract: This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Abstract translation: 本发明提供了一种用于治疗各种微生物感染的结晶阿奇霉素L-苹果酸盐一水合物，其具有高的热稳定性，溶解性和非吸湿性，其制备方法和含有它们的药物组合物。

公开(公告)号：US06939956B2

公开(公告)日：2005-09-06

申请号：US10146305

申请日：2002-05-15

Applicant: Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Moo Young Song ,  Tae Hun Song ,  Chang Seok Kim

Inventor： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Moo Young Song ,  Tae Hun Song ,  Chang Seok Kim

IPC: C12N15/09 ,  C07K16/08 ,  C12N1/21 ,  C12N15/33 ,  C12N15/36 ,  C12N15/51 ,  C12P21/08 ,  C12R1/19 ,  C07H21/04 ,  C12N15/00

CPC classification number: C07K16/082 ,  C07K2317/56 ,  C07K2317/92 ,  C12N2730/10122

Abstract: The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatitis B virus and a gene encoding the same, a recombinant vector containing the gene, and a transformant obtained from the recombinant vector.

Abstract translation: 本发明涉及针对乙型肝炎病毒的S表面抗原的单克隆抗体的可变区和编码该抗体的基因，含有该基因的重组载体和从重组载体获得的转化体。