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    Method of oxidation using nitric acid
    4.
    发明授权
    Method of oxidation using nitric acid 有权
    使用硝酸的氧化方法

    公开(公告)号：US09162959B2

    公开(公告)日：2015-10-20

    申请号：US14150633

    申请日：2014-01-08

    Applicant: The University of Montana

    Inventor： Donald E. Kiely ,  Kirk R. Hash, Sr.

    IPC: C07C51/00 ,  C07C51/27

    CPC classification number: C07C51/27 ,  C07C51/00 ,  C07C59/285

    Abstract: A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

    Abstract translation: 使用使用氧和硝酸作为辅助氧化剂的受控硝酸方法将经受硝酸氧化的有机化合物氧化成其相应的羧酸。 通过该方法氧化一些碳水化合物可以产生一种或多种相应的酸形式。 该方法在中等温度下进行，通常在封闭反应器中在20℃至45℃的范围内，根据需要将氧气引入反应室，以维持反应。 计算机控制的反应器允许仔细和可重复地控制反应参数。 硝酸可以通过蒸馏/蒸发过程或通过扩散透析回收，水溶液用无机氢氧化物制成碱性，并且使用过滤（纳滤）装置除去残留的无机硝酸盐。 该方法消除了氧化的热控制，氮气释放到大气中的问题，以及去除硝酸和无机硝酸盐的后反应困难。

    Novel Aspartylamide Inhibitors of Excitatory Amino Acid Transporters
    5.
    发明申请
    Novel Aspartylamide Inhibitors of Excitatory Amino Acid Transporters 审中-公开
    兴奋性氨基酸转运蛋白的新型天冬氨酰胺抑制剂

    公开(公告)号：US20150023878A1

    公开(公告)日：2015-01-22

    申请号：US14382508

    申请日：2013-03-05

    Applicant: THE UNIVERSITY OF MONTANA

    Inventor： John M. Gerdes ,  Richard J. Bridges ,  Syed K. Ahmed ,  Sarjubhai Patel

    IPC: C07C69/635 ,  C07C67/317 ,  C07F7/22 ,  A61K51/04 ,  C07B59/00

    CPC classification number: C07C69/635 ,  A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C67/317 ,  C07C237/04 ,  C07C2603/18 ,  C07F7/2208

    Abstract: The compounds of the invention are inhibitors of excitatory amino acid transporters (EAAT) that penetrate the blood-brain barrier to access the central nervous system. The compounds of the invention follow the structural formula: or a salt, ester or prodrug thereof, wherein X is a halogen, such as fluorine, or a radionuclide, such as fluorine-18. The compounds and methods described herein can be used for the treatment of, e.g., neurodegenerative disorders (e.g., amyotrophic lateral sclerosis), ischemia, spinal cord injury, and traumatic brain injury in a patient (e.g., a human). The invention further provides compounds and methods for the synthesis and use of radiographic tracers to diagnose and follow the progression of such disorders.

    Abstract translation: 本发明的化合物是穿透血脑屏障进入中枢神经系统的兴奋性氨基酸转运蛋白（EAAT）的抑制剂。 本发明的化合物遵循以下结构式：或其盐，酯或前药，其中X为卤素，如氟，或放射性核素如氟-18。 本文所述的化合物和方法可用于治疗例如患者（例如人）中的神经变性疾病（例如肌萎缩性侧索硬化），缺血，脊髓损伤和创伤性脑损伤。 本发明还提供了用于合成和使用放射照相示踪剂以诊断和跟踪这些疾病进展的化合物和方法。

    APPARATUSES AND METHODS FOR TESTING ELECTROCHEMICAL CELLS BY MEASURING FREQUENCY RESPONSE
    6.
    发明申请
    APPARATUSES AND METHODS FOR TESTING ELECTROCHEMICAL CELLS BY MEASURING FREQUENCY RESPONSE 审中-公开
    通过测量频率响应测试电化学电池的方法和方法

    公开(公告)号：US20140358462A1

    公开(公告)日：2014-12-04

    申请号：US14296321

    申请日：2014-06-04

    Applicant: Battelle Energy Alliance, LLC ,  Montana Tech of the University of Montana ,  Qualtech Systems, Inc.

    Inventor： Jon P. Christophersen ,  John L. Morrison ,  William H. Morrison ,  Patrick A. Bald

    IPC: G01R31/36

    CPC classification number: G01R31/392 ,  G01R31/389

    Abstract: Real-time battery impedance spectra are acquired by stimulating a battery or battery system with a signal generated as a sum of sine signals at related frequencies. An impedance measurement device can be used to interface between the battery system and a host computer for generating the signals. The impedance measurement device may be calibrated to adapt the response signal to more closely match other impedance measurement techniques. The impedance measurement device may be adapted to operate at mid-range voltages of about 50 volts and high-range voltages up to about 300 volts.

    Abstract translation: 通过以相关频率的正弦信号的和产生的信号来刺激电池或电池系统来获取实时电池阻抗谱。 阻抗测量装置可用于在电池系统和主计算机之间进行接口以产生信号。 可以校准阻抗测量装置以使响应信号更适应其他阻抗测量技术。 阻抗测量装置可以适于在约50伏的中等范围电压和高达约300伏的高范围电压下工作。

    Water soluble lipidated arabinogalactan
    8.
    发明申请
    Water soluble lipidated arabinogalactan 审中-公开

    公开(公告)号：US20010036933A1

    公开(公告)日：2001-11-01

    申请号：US09845915

    申请日：2001-04-30

    Applicant: The University of Montana

    Inventor： Geoffrey N. Richards

    IPC: C08B037/00 ,  A61K031/715

    CPC classification number: C08B37/006 ,  A61K47/61

    Abstract: Arabinogalactan compositions are provided which are useful in a wide variety of different biomedical applications. In one embodiment, water soluble lipidated arabinogalactans are provided which include arabinogalactan with a limited proportion of lipophilic groups, such as long-chain hydrocarbon groups, covalently attached to free hydroxyl groups on the arabinogalactan. The lipidated arabinogalactans are water soluble and biocompatible and are useful for a wide variety of different biomedical applications. The lipidated arabinogalactans can be used, for example, to inhibit cell adhesion, and to inhibit infection or inflammation. The lipidated arabinogalactans further may be used as adjuvants, to inhibit metastasis, and in other therapeutic applications.

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