公开(公告)号：US20240325517A1

公开(公告)日：2024-10-03

申请号：US18245233

申请日：2021-09-15

Applicant: THE UNIVERSITY OF MONTANA ,  INIMMUNE CORPORATION

Inventor： Patrick Secor ,  Jay Evans ,  David Burkhart

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/04

CPC classification number: A61K39/12 ,  A61P31/04 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/627 ,  A61K2039/70 ,  C07K2319/55 ,  C12N2795/14234

Abstract: Multivalent conjugates and conjugate compositions of peptides derived from the CoaB coat protein of Pseudomonas aeruginosa filamentous (Pf) bacteriophage and conjugates adjuvanted with a TLR 4 and/or TLR 7/8 agonist induce and/or enhance an immune response toward Pseudomonas aeruginosa filamentous (Pf) bacteriophage. The conjugates, compositions, and vaccines have utility to reduce, prevent and/or ameliorate the adverse effect of Pseudomonas aeruginosa infection, such as biofilm formation.

公开(公告)号：US11572381B2

公开(公告)日：2023-02-07

申请号：US16970753

申请日：2019-03-01

Applicant: THE UNIVERSITY OF MONTANA

Inventor： David Burkhart ,  Jay Evans ,  Craig Johnson ,  Kendal T. Ryter ,  Alyson Smith ,  Walid Abdelwahab Marzouky Abdelwahab

IPC: C07H19/056 ,  A61K31/7056 ,  C07H7/06 ,  C07H15/04 ,  A61K39/39 ,  A61K39/00

Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

公开(公告)号：US20240024469A1

公开(公告)日：2024-01-25

申请号：US18446041

申请日：2023-08-08

Applicant: THE UNIVERSITY OF MONTANA

Inventor： Helene Bazin-Lee ,  David Burkhart ,  Jay Evans

IPC: A61K39/39 ,  C07F9/6561

CPC classification number: A61K39/39 ,  C07F9/65616 ,  A61K2039/55505

Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.

公开(公告)号：US20230310438A1

公开(公告)日：2023-10-05

申请号：US17769037

申请日：2020-10-16

Applicant: Children's Medical Center Corporation ,  The University of Montana ,  Regents of the University of Minnesota

Inventor： David J. Dowling ,  Ofer Levy ,  Dheeraj Soni ,  Sharon Levy ,  Jay Evans ,  Marco Pravetoni ,  David Burkhart ,  Shannon Miller

IPC: A61K31/522 ,  A61K31/4745 ,  A61K31/7028 ,  A61K31/4468 ,  A61K39/00 ,  A61P25/36

CPC classification number: A61K31/522 ,  A61K31/4745 ,  A61K31/7028 ,  A61K31/4468 ,  A61K2039/55511 ,  A61P25/36 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K39/0013

Abstract: Provided herein are TLR7/8 agonists to enhance immune responses or for use as adjuvants in fentanyl vaccines in opioid-using individuals.

公开(公告)号：US20210139521A1

公开(公告)日：2021-05-13

申请号：US16968075

申请日：2019-02-21

Applicant: THE UNIVERSITY OF MONTANA

Inventor： David Burkhart ,  George Ettenger ,  Jay Evans ,  Kendal T. Ryter ,  Alyson Smith

IPC: C07H13/08 ,  A61K39/39 ,  A61K39/04 ,  A61P37/04

Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

公开(公告)号：US20200369704A1

公开(公告)日：2020-11-26

申请号：US16970753

申请日：2019-03-01

Applicant: THE UNIVERSITY OF MONTANA

Inventor： David Burkhart ,  Jay Evans ,  Craig Johnson ,  Kendal T. Ryter ,  Alyson Smith ,  Walid Abdelwahab Marzouky Abdelwahab

IPC: C07H15/04 ,  A61K39/39

Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

公开(公告)号：US20240309037A1

公开(公告)日：2024-09-19

申请号：US18437424

申请日：2024-02-09

Applicant: THE UNIVERSITY OF MONTANA

Inventor： David Burkhart ,  George Ettenger ,  Jay Evans ,  Kendal T. Ryter ,  Alyson Smith

IPC: C07H13/08 ,  A61K39/04 ,  A61K39/39 ,  A61P37/04 ,  C07H15/04

CPC classification number: C07H13/08 ,  A61K39/04 ,  A61K39/39 ,  A61P37/04 ,  C07H15/04

Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

公开(公告)号：US11964014B2

公开(公告)日：2024-04-23

申请号：US18446041

申请日：2023-08-08

Applicant: THE UNIVERSITY OF MONTANA

Inventor： Helene Bazin-Lee ,  David Burkhart ,  Jay Evans

IPC: A61K39/39 ,  A61K39/00 ,  C07F9/6561

CPC classification number: A61K39/39 ,  C07F9/65616 ,  A61K2039/55505 ,  A61K2039/55511

Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.

公开(公告)号：US11912736B2

公开(公告)日：2024-02-27

申请号：US16968075

申请日：2019-02-21

Applicant: THE UNIVERSITY OF MONTANA

Inventor： David Burkhart ,  George Ettenger ,  Jay Evans ,  Kendal T. Ryter ,  Alyson Smith

IPC: C07H13/08 ,  A61P37/04 ,  A61K39/04 ,  A61K39/39 ,  C07H15/04

CPC classification number: C07H13/08 ,  A61K39/04 ,  A61K39/39 ,  A61P37/04 ,  C07H15/04

Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

公开(公告)号：US20220241410A1

公开(公告)日：2022-08-04

申请号：US17613414

申请日：2020-05-22

Applicant: THE UNIVERSITY OF MONTANA

Inventor： Helene Bazin-Lee ,  David Burkhart ,  Jay Evans

IPC: A61K39/39 ,  C07F9/6561

Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmnune disorders.