公开(公告)号：US20250051459A1

公开(公告)日：2025-02-13

申请号：US18719798

申请日：2022-12-16

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI ,  Huy Tuan NGUYEN ,  Yorick POST ,  Wen-Chen YEH

IPC: C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61P27/02 ,  C07K14/475

Abstract: Methods and compositions for treatment of dry-eye disorders are provided. In particular, the present disclosure provides methods and compositions for modulating WNT (Wingless and lnt-1) signaling in a subject to modulate regeneration of tear-producing acinar cells to treat aqueous-deficient type dry-eye diseases. Further disclosed are WNT signaling modulators used in the methods.

公开(公告)号：US20240368287A1

公开(公告)日：2024-11-07

申请号：US18652070

申请日：2024-05-01

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI ,  Tom Zhiye YUAN ,  Aaron Ken SATO ,  Wen-Chen YEH ,  Chenggang LU ,  Parthasarathy SAMPATHKUMAR ,  Claudia Yvonne JANDA

IPC: C07K16/28

Abstract: The present invention provides anti-Fzd monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

公开(公告)号：US20230138045A1

公开(公告)日：2023-05-04

申请号：US17801624

申请日：2021-02-24

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI

IPC: C07K16/28 ,  A61P43/00

Abstract: The present invention provides multispecific multivalent antigen binding molecules that can function as WNT agonist, WNT enhancer, and WNT super agonist molecules by binding and activating at least one or two WNT receptors and a WNT enhancer.

公开(公告)号：US20240150458A1

公开(公告)日：2024-05-09

申请号：US18350589

申请日：2023-07-11

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI ,  Tom Zhiye YUAN ,  Aaron Ken SATO ,  Wen-Chen YEH ,  Parthasarathy SAMPATHKUMAR

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present invention provides anti-LRP5/6 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for treating diseases and disorders associated with Wnt pathway signaling.

公开(公告)号：US20230295347A1

公开(公告)日：2023-09-21

申请号：US18148448

申请日：2022-12-30

Applicant: Surrozen Operating, Inc.

Inventor： Hui CHEN ,  Sungjin LEE ,  Yang LI ,  Wen-Chen YEH

IPC: C07K16/46 ,  C12N15/63 ,  A61P27/02

CPC classification number: C07K16/468 ,  C12N15/63 ,  A61P27/02 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/52

Abstract: The present invention provides compounds which specifically bind to one or more Wnt receptors and methods relating thereto. In some aspects, compositions and methods for treating ocular disorders with modulators of the Wnt signaling pathway are provided. In particular, the ocular disorders are retinopathies. Also provided are methods of dosing and pharmaceutical compositions.

公开(公告)号：US11746150B2

公开(公告)日：2023-09-05

申请号：US16954483

申请日：2018-12-19

Applicant: Surrozen Operating, Inc.

Inventor： Yang Li ,  Tom Zhiye Yuan ,  Aaron Ken Sato ,  Wen-Chen Yeh ,  Parthasarathy Sampathkumar

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present invention provides anti-LRP5/6 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for treating diseases and disorders associated with Wnt pathway signaling.

公开(公告)号：US20240141049A1

公开(公告)日：2024-05-02

申请号：US18361782

申请日：2023-07-28

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI ,  Tom Zhiye YUAN ,  Aaron Ken SATO ,  Wen-Chen YEH ,  Claudia Yvonne JANDA ,  Tristan William FOWLER ,  Helene BARIBAULT ,  Kuo-Pao LAI ,  Liqin XIE ,  Randall J. BREZSKI ,  Chenggang LU

IPC: C07K16/28 ,  C07K16/46

CPC classification number: C07K16/2863 ,  C07K16/468 ,  A61K2039/505

Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

公开(公告)号：US20230374090A1

公开(公告)日：2023-11-23

申请号：US18311082

申请日：2023-05-02

Applicant: Surrozen Operating, Inc.

Inventor： Yang LI ,  Zhengjian ZHANG ,  Randall J. BREZSKI ,  Leonard PRESTA ,  Thomas LOPEZ ,  Hui CHEN ,  Helene BARIBAULT ,  Wen-Chen YEH ,  Shengjiang TU

IPC: C07K14/47 ,  C07K16/24 ,  A61P1/16

CPC classification number: C07K14/4705 ,  C07K16/24 ,  A61P1/16 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2319/03 ,  A61K38/00

Abstract: The present disclosure provides liver-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues and treat liver diseases and disorders.

公开(公告)号：US20220195053A1

公开(公告)日：2022-06-23

申请号：US17438303

申请日：2020-03-11

Applicant: Surrozen Operating Inc.

Inventor： Yang LI ,  Chenggang LU ,  Hélène BARIBAULT ,  Wen-Chen YEH ,  Liqin XIE ,  I-Chieh WANG ,  Weixu MENG

IPC: C07K16/28 ,  A61P1/00

Abstract: The present invention provides methods of treating gastrointestinal disorders with modulators of the WNT signaling pathway. Also provided are methods of dosing and pharmaceutical compositions.

公开(公告)号：US20240279303A1

公开(公告)日：2024-08-22

申请号：US18597679

申请日：2024-03-06

Applicant: Surrozen Operating, Inc.

Inventor： Zhengjian ZHANG ,  Jennifer Jean BRADY ,  Aaron Ken SATO ,  Wen-Chen YEH ,  Yang LI ,  Teppei YAMAGUCHI

IPC: C07K14/705 ,  A61K47/65 ,  C07K14/47 ,  C07K16/28 ,  C07K16/40 ,  C12N15/62

CPC classification number: C07K14/705 ,  A61K47/65 ,  C07K14/47 ,  C07K16/2851 ,  C07K16/2881 ,  C07K16/40 ,  C12N15/62 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2319/30

Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.