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    Isolation, purification and synthesis of procyanidin B2 and uses thereof
    1.
    发明授权
    Isolation, purification and synthesis of procyanidin B2 and uses thereof 有权
    原花青素B2的分离，纯化和合成及其用途

    公开(公告)号：US09133176B2

    公开(公告)日：2015-09-15

    申请号：US12119212

    申请日：2008-05-12

    申请人： Gerardo Castillo ,  Beth Nguyen ,  Paula Choi ,  Lesley Larsen ,  Stephen Lorimer ,  Alan Snow

    发明人： Gerardo Castillo ,  Beth Nguyen ,  Paula Choi ,  Lesley Larsen ,  Stephen Lorimer ,  Alan Snow

    IPC分类号： C07D323/00 ,  C07D321/00 ,  C07D311/00 ,  C07D407/04 ,  C07D321/10 ,  C07D311/62

    CPC分类号： C07D407/04 ,  C07D311/62 ,  C07D321/10 ,  C07D323/00

    摘要： Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

    摘要翻译： 公开了原花青素B2的合成，分离和纯化方法。 合成方法利用表儿茶素作为原料，以高产率生产原花青素B2。 分离方法从Uncaria属植物物质的树皮粉样品中提取原花青素B2。 分离和/或合成的原花青素B2用于治疗淀粉样变性疾病，如阿尔茨海默病和帕金森病，以及提高阿尔茨海默病患者的认知能力和增加学习和记忆能力。 还公开了含有合成和/或分离的原花青素B2的药物组合物。

    Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof
    4.
    发明申请
    Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof 审中-公开
    原花青素B2的分离，纯化和合成及其用途

    公开(公告)号：US20080306286A1

    公开(公告)日：2008-12-11

    申请号：US12124929

    申请日：2008-05-21

    申请人： Alan Snow ,  Gerardo Castillo ,  Paula Choi ,  Beth Nguyen ,  Stephen Lorimer ,  Lesley Larsen

    发明人： Alan Snow ,  Gerardo Castillo ,  Paula Choi ,  Beth Nguyen ,  Stephen Lorimer ,  Lesley Larsen

    IPC分类号： C07D407/02

    CPC分类号： C07D407/04 ,  C07D311/62 ,  C07D321/10 ,  C07D323/00

    摘要： Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

    摘要翻译： 公开了原花青素B2的合成，分离和纯化方法。 合成方法利用表儿茶素作为原料，以高产率生产原花青素B2。 分离方法从Uncaria属植物物质的树皮粉样品中提取原花青素B2。 分离和/或合成的原花青素B2用于治疗淀粉样变性疾病，如阿尔茨海默病和帕金森病，以及提高阿尔茨海默病患者的认知能力和增加学习和记忆能力。 还公开了含有合成和/或分离的原花青素B2的药物组合物。

    Isolation, purification and synthesis of procyanidin B2 and uses thereof
    7.
    发明申请
    Isolation, purification and synthesis of procyanidin B2 and uses thereof 有权
    原花青素B2的分离，纯化和合成及其用途

    公开(公告)号：US20080306142A1

    公开(公告)日：2008-12-11

    申请号：US12119212

    申请日：2008-05-12

    申请人： Gerardo Castillo ,  Beth Nguyen ,  Paula Choi ,  Lesley Larsen ,  Stephen Lorimer ,  Alan Snow

    发明人： Gerardo Castillo ,  Beth Nguyen ,  Paula Choi ,  Lesley Larsen ,  Stephen Lorimer ,  Alan Snow

    IPC分类号： A61K31/353 ,  A61P25/28

    CPC分类号： C07D407/04 ,  C07D311/62 ,  C07D321/10 ,  C07D323/00

    摘要： Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

    摘要翻译： 公开了原花青素B2的合成，分离和纯化方法。 合成方法利用表儿茶素作为原料，以高产率生产原花青素B2。 分离方法从Uncaria属植物物质的树皮粉样品中提取原花青素B2。 分离和/或合成的原花青素B2用于治疗淀粉样变性疾病，如阿尔茨海默病和帕金森病，以及提高阿尔茨海默病患者的认知能力和增加学习和记忆能力。 还公开了含有合成和/或分离的原花青素B2的药物组合物。