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1.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes and parkinson's disease 有权用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US08163957B2
公开(公告)日：2012-04-24
申请号：US12837721
申请日：2010-07-16
申请人： Alan D Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T Weavers , Stephen Lorimer , David Larsen , David L Coffen , Charlotte Coffen, legal representative
发明人： Alan D Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T Weavers , Stephen Lorimer , David Larsen , David L Coffen
IPC分类号： C07C237/14 , C07C237/20 , A61K31/16
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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2.发明申请Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease 有权用于治疗淀粉样疾病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US20110172239A1
公开(公告)日：2011-07-14
申请号：US12837721
申请日：2010-07-16
申请人： Alan D. SNOW , Beth NGUYEN , Gerardo CASTILLO , Virginia SANDERS , Thomas LAKE , Lesley LARSEN , Rex T. WEAVERS , Stephen LORIMER , David LARSEN , David L. COFFEN , Charlotte COFFEN
发明人： Alan D. SNOW , Beth NGUYEN , Gerardo CASTILLO , Virginia SANDERS , Thomas LAKE , Lesley LARSEN , Rex T. WEAVERS , Stephen LORIMER , David LARSEN , David L. COFFEN , Charlotte COFFEN
IPC分类号： A61K31/495 , C07C49/83 , A61K31/12 , A61P25/28 , A61P25/00 , A61P25/16 , C07C39/16 , A61K31/05 , A61K31/4418 , C07D213/85 , C07D295/096 , C07C215/50 , A61K31/137 , C07D451/06 , A61K31/46 , C07C235/50 , A61K31/166
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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3.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease 失效用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US08586585B2
公开(公告)日：2013-11-19
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen
IPC分类号： A01N43/58 , A61K31/50 , A61K31/497 , A01N43/40 , A61K31/435
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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4.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES AND PARKINSON'S DISEASE 失效化合物，组合物和治疗淀粉样变性疾病和合并症的方法，如阿尔茨海默病，2型糖尿病和帕金森病公开(公告)号：US20120225890A1
公开(公告)日：2012-09-06
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
IPC分类号： A61K31/495 , C07D211/44 , A61K31/45 , C07D295/10 , C07D241/04 , A61P25/16 , A61K31/44 , C07D213/69 , A61P25/28 , A61P3/10 , A61P29/00 , A61P35/00 , C07D295/096 , C07D213/30
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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5.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease 有权用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US07514583B2
公开(公告)日：2009-04-07
申请号：US10452851
申请日：2003-05-30
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , Charlotte Coffen, legal representative
发明人： David L. Coffen
IPC分类号： C07C233/75 , A61K31/165
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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6.发明申请SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES 审中-公开取代的N-亚苄基苯甲酸和相关化合物用于治疗淀粉样变性疾病和综合征公开(公告)号：US20110104055A1
公开(公告)日：2011-05-05
申请号：US12940330
申请日：2010-11-05
申请人： Alan Snow , Manfred Weigele , Lesley Larsen , Beth Nguyen , Thomas Lake , Gerardo Castillo , Virginia Sanders , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
发明人： Alan Snow , Manfred Weigele , Lesley Larsen , Beth Nguyen , Thomas Lake , Gerardo Castillo , Virginia Sanders , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
IPC分类号： A61K31/167 , C07C233/75 , A61K51/00 , A61P43/00
CPC分类号： C07C235/56
摘要： Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.
摘要翻译： 化合物及其药学上可接受的盐，它们的合成和标记，含有它们的药物组合物及其在治疗淀粉样疾病中的用途，包括A＆bgr; 提供淀粉样变性，例如在阿尔茨海默病中观察到的，IAPP淀粉样变性，例如在2型糖尿病中观察到的，以及突触核蛋白病，例如在帕金森病中观察到的，并且制备用于这种治疗的药物。 还提供了所公开的化合物作为淀粉样蛋白和突触核蛋白的体内成像和检测的成像剂和方法的用途。
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7.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease 失效用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US07763747B2
公开(公告)日：2010-07-27
申请号：US12264858
申请日：2008-11-04
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen
IPC分类号： C07C69/035 , C07C69/21 , A61K31/222 , A61K31/225
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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8.发明授权Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis 有权用于治疗淀粉样变性疾病如全身性AA淀粉样变性的化合物，组合物和方法公开(公告)号：US07601876B2
公开(公告)日：2009-10-13
申请号：US11714894
申请日：2007-03-05
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen
IPC分类号： C07C33/00 , C07C49/00 , C07C209/00 , C07C211/00 , C07C233/00 , C07C239/00 , C07C275/00 , A61K31/00
CPC分类号： C07C39/15 , C07C39/16 , C07C39/17 , C07C69/017 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，AA / SAA淀粉样变性，例如在全身性AA淀粉样变性和突触核蛋白病中观察到的，例如在帕金森病中观察到的，以及制备用于这种治疗的药物。
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公开(公告)号：US20090197965A1
公开(公告)日：2009-08-06
申请号：US12269017
申请日：2008-11-11
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , David S. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen , Stephen D. Lorimer
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , David S. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen , Stephen D. Lorimer
IPC分类号： A61K31/17 , C07C233/56 , A61K31/167 , C07C275/34 , A61P25/28
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
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10.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 失效用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法公开(公告)号：US20090069432A1
公开(公告)日：2009-03-12
申请号：US12264858
申请日：2008-11-04
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen
IPC分类号： A61K31/167 , C07C233/75
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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