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    SYSTEM AND METHOD FOR AUTO-RANGING IN OPTICAL COHERENCE TOMOGRAPHY
    2.
    发明申请
    SYSTEM AND METHOD FOR AUTO-RANGING IN OPTICAL COHERENCE TOMOGRAPHY 有权
    用于光学相干坐标自动调节的系统和方法

    公开(公告)号：US20130162948A1

    公开(公告)日：2013-06-27

    申请号：US13335211

    申请日：2011-12-22

    申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    IPC分类号： A61B3/15 ,  G01B9/02

    CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B3/12 ,  G01B9/02048 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02091

    摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

    摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS
    3.
    发明申请
    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS 审中-公开
    用于基于光源分布的细胞外分泌的系统

    公开(公告)号：US20130052725A1

    公开(公告)日：2013-02-28

    申请号：US13285976

    申请日：2011-10-31

    申请人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    IPC分类号： C12M1/42

    CPC分类号： C12M35/02

    摘要： A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

    摘要翻译： 用于递送外源分子的系统包括用于含有细胞和外源分子的载体; 红外（IR）光源，其产生平均功率密度至少大于105W / cm2的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对细胞进行成像; 处理器，其在视野中产生用于细胞定位的信号; 用于光束的时间聚焦的光图案整形器以在细胞上产生宽场照明以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。

    SYSTEM AND METHOD FOR CONTRAST ENHANCEMENT OF TIME-RESOLVED FLUORESCENCE IMAGES
    4.
    发明申请
    SYSTEM AND METHOD FOR CONTRAST ENHANCEMENT OF TIME-RESOLVED FLUORESCENCE IMAGES 失效
    用于对比度增强时间分辨率荧光图像的系统和方法

    公开(公告)号：US20100220903A1

    公开(公告)日：2010-09-02

    申请号：US12394381

    申请日：2009-02-27

    申请人： Andrzej May ,  Siavash Yazdanfar

    发明人： Andrzej May ,  Siavash Yazdanfar

    IPC分类号： G06K9/40 ,  G06K9/46 ,  G06K9/00

    CPC分类号： G06K9/2018 ,  G01N21/6408 ,  G01N21/6456 ,  G06K9/00134

    摘要： A method of fluorescence imaging is provided. The method provides for simultaneously acquiring image data at a plurality of phases and a plurality of frequencies from a region of interest, identifying at least one desired signal and at least one background signal in the acquired image data associated with the region of interest, constructing a digital filter based upon the at least one desired signal and the at least one background signal, wherein the digital filter is configured to enhance image contrast and applying the digital filter to the acquired image data associated with the region of interest to enhance image contrast in the acquired image data. Systems and computer programs that afford functionality of the type defined by this method are also provided.

    摘要翻译： 提供荧光成像的方法。 该方法提供从感兴趣区域的多个相位和多个频率同时获取图像数据，识别所获取的与感兴趣区域相关联的图像数据中的至少一个期望信号和至少一个背景信号，构建一个 数字滤波器，其基于所述至少一个期望信号和所述至少一个背景信号，其中所述数字滤波器被配置为增强图像对比度并将所述数字滤波器应用于所获取的与所述感兴趣区域相关联的图像数据，以增强所述图像对比度 获取的图像数据。 还提供了提供由该方法定义的类型的功能的系统和计算机程序。

    ENDOSCOPE OBJECTIVE LENS WITH LARGE ENTRANCE PUPIL DIAMETER AND HIGH NUMERICAL APERTURE
    6.
    发明申请
    ENDOSCOPE OBJECTIVE LENS WITH LARGE ENTRANCE PUPIL DIAMETER AND HIGH NUMERICAL APERTURE 有权
    内窥镜具有大的入口直径和高数值孔径的目镜

    公开(公告)号：US20090290236A1

    公开(公告)日：2009-11-26

    申请号：US12125512

    申请日：2008-05-22

    申请人： Xinghua Wang ,  Siavash Yazdanfar

    发明人： Xinghua Wang ,  Siavash Yazdanfar

    IPC分类号： G02B13/04

    CPC分类号： G02B23/243

    摘要： An endoscope objective lens for collecting combined bright field (white light) and fluorescence images includes a negative lens group, a stop, and a positive lens group. The lens has a combination of large entrance pupil diameter (≧0.4 mm) for efficiently collecting weak fluorescence light, large ratio between the entrance pupil diameter and the maximum outside diameter (Dentrance/Dmax larger than 0.2), large field of view (FFOV≧120°) and favorably corrected spherical, lateral chromatic and Petzval field curvature for both visible and near infrared wavelengths.

    摘要翻译： 用于收集组合亮场（白光）和荧光图像的内窥镜物镜包括负透镜组，光阑和正透镜组。 透镜具有大的入射光瞳直径（> = 0.4mm）的组合，用于有效地收集弱荧光，入射光瞳直径与最大外径之比大（Dentrance / Dmax大于0.2），大视野（FFOV > = 120°），并且对于可见光和近红外波长都有良好校正的球面，横向色度和Petzval场曲率。

    METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM
    8.
    发明申请
    METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 有权
    光学成像技术在散射介质中的目标检测方法与系统

    公开(公告)号：US20120128264A1

    公开(公告)日：2012-05-24

    申请号：US12952359

    申请日：2010-11-23

    申请人： Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

    发明人： Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

    IPC分类号： G06K9/40 ,  G01J1/58

    CPC分类号： A61B5/0059 ,  A61B5/0064

    摘要： A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

    摘要翻译： 提供了一种增强荧光成像对比度的方法。 该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除 来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

    OBJECTIVE FOR OPTICAL IMAGING SYSTEMS
    9.
    发明申请
    OBJECTIVE FOR OPTICAL IMAGING SYSTEMS 有权
    光学成像系统的目标

    公开(公告)号：US20110043916A1

    公开(公告)日：2011-02-24

    申请号：US12543785

    申请日：2009-08-19

    申请人： Xinghua Wang ,  Mark Marshall Meyers ,  Siavash Yazdanfar

    发明人： Xinghua Wang ,  Mark Marshall Meyers ,  Siavash Yazdanfar

    IPC分类号： G02B23/24 ,  G02B27/42

    CPC分类号： G02B23/243

    摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.

    摘要翻译： 提供广角混合折射衍射内窥镜目的。 该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距： 约0.8mm至约1.6mm。

    Iris imaging system and method for the same
    10.
    发明授权
    Iris imaging system and method for the same 有权
    虹膜成像系统和方法相同

    公开(公告)号：US07824034B2

    公开(公告)日：2010-11-02

    申请号：US11857581

    申请日：2007-09-19

    申请人： Frederick Wilson Wheeler ,  Siavash Yazdanfar

    发明人： Frederick Wilson Wheeler ,  Siavash Yazdanfar

    IPC分类号： A61B3/14 ,  A61B3/00 ,  A61B3/10

    CPC分类号： A61B3/1216 ,  A61B3/14

    摘要： An iris imaging system is provided. The iris imaging system includes at least one light source configured to illuminate an iris at a spectrum of light. The iris imaging system also includes at least one image capturing device including at least one of an indium-gallium-arsenide, lead sulphide, and lead selenide based detector and configured to capture an image of the iris via light reflected from the iris at the spectrum. The device is further configured to provide a signal representing one or more features of the iris in response to the light reflected from the iris.

    摘要翻译： 提供虹膜成像系统。 虹膜成像系统包括至少一个被配置为以光谱照射虹膜的光源。 虹膜成像系统还包括至少一个图像捕获装置，其包括砷化铟镓，硫化铅和基于硒化铅的检测器中的至少一种，并被配置为通过光谱从光谱反射的光线捕获虹膜的图像 。 该装置还被配置为响应于从虹膜反射的光来提供表示虹膜的一个或多个特征的信号。