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公开(公告)号：US20110210255A1
公开(公告)日：2011-09-01
申请号：US12714529
申请日：2010-02-28
IPC分类号： G01T1/20
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method for producing a PET image of a tissue using a PET scanner, the scanner comprising a plurality of scintillation crystals (70X/75X) and a plurality of detectors (71X/76X). The method comprises forming a first crystal group (160X) including a first subset of the plurality of crystals; forming a second crystal group (164X) including a second subset of the plurality of crystals, wherein crystals comprising the first crystal group (160X) are different from crystals comprising the second crystal group (164X); converting a first beam (120) striking one or more crystals of the first crystal group (70X/160X) to a first electrical signal (94); converting a second beam striking one or more crystals of the second crystal group (75X/164X) to a second electrical signal (98), wherein the second beam is scattered from the first beam; determining one or both of a first and a second timing relationship, wherein the first timing relationship (Δt2) is a time interval between a value of the first electrical signal (94) and a time reference (t1), and the second timing relationship (Δt3) is a time interval between a value of the second electrical signal (98) and the time reference (t1); correcting the second electrical signal (98) to produce a corrected second electrical signal using a correction factor derived from at least one of the first and the second timing relationships to compensate for energy in the second signal scattered from the first signal; and creating an image of the tissue (12) using the corrected second electrical signal.
摘要翻译： 一种使用PET扫描仪生产组织的PET图像的方法，所述扫描器包括多个闪烁晶体（70X / 75X）和多个检测器（71X / 76X）。 该方法包括形成包括多个晶体的第一子集的第一晶体组（160X） 形成包含多个晶体的第二子集的第二晶体组（164X），其中包含第一晶体组（160X）的晶体与包含第二晶体组（164X）的晶体不同; 将第一晶体组（70X / 160X）的一个或多个晶体的第一光束（120）转换成第一电信号（94）; 将第二晶体组（75X / 164X）的一个或多个晶体的第二光束转换成第二电信号（98），其中所述第二光束从所述第一光束散射; 确定第一和第二定时关系中的一个或两个，其中所述第一定时关系（＆Dgr; t2）是所述第一电信号（94）的值与时间基准（t1）之间的时间间隔和所述第二定时 关系（＆Dgr; t3）是第二电信号（98）的值与时间基准（t1）之间的时间间隔; 使用从第一和第二定时关系中的至少一个导出的校正因子校正第二电信号（98）以产生校正的第二电信号，以补偿从第一信号散射的第二信号中的能量; 以及使用校正的第二电信号创建组织（12）的图像。
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公开(公告)号：US20090022278A1
公开(公告)日：2009-01-22
申请号：US11778290
申请日：2007-07-16
IPC分类号： G21K1/02
摘要： Embodiments relate to an imaging system that includes a collimator assembly having one or more pinhole apertures therein. The imaging system is configured so that one or more of the pinhole apertures has an adjustable focal length. The imaging system further includes a detector assembly configured to generate one or more signals in response to gamma rays that pass through the one or more pinhole apertures. Embodiments also relate to methods of changing collimator performance and methods of imaging a volume.
摘要翻译： 实施例涉及一种成像系统，其包括其中具有一个或多个针孔的准直器组件。 成像系统被配置为使得一个或多个针孔具有可调整的焦距。 成像系统还包括检测器组件，其被配置为响应于穿过所述一个或多个针孔的伽马射线产生一个或多个信号。 实施例还涉及改变准直器性能的方法和对体积进行成像的方法。
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公开(公告)号：US20110220783A1
公开(公告)日：2011-09-15
申请号：US12720451
申请日：2010-03-09
CPC分类号： G01T1/1647 , G01T7/005
摘要： Methods and systems for calibrating a nuclear medicine imaging are provided. One method includes acquiring spatially determined non-uniform radiation flux information from a calibration scan of a calibration source using a gamma camera having an attached non-parallel-hole collimator. The method further includes determining a measured non-uniform count density profile from the acquired non-uniform radiation flux information. The method also includes creating a gamma camera uniformity correction map derived from (i) the measured non-uniform count density profile and (ii) a modeled or calculated non-uniform count density profile for calibrating the NM imaging system.
摘要翻译： 提供了用于校准核医学成像的方法和系统。 一种方法包括使用具有附接的非平行孔准直器的伽马照相机从校准源的校准扫描获取空间上确定的不均匀辐射通量信息。 该方法还包括从所获取的非均匀辐射通量信息确定测量的不均匀计数密度分布。 该方法还包括创建从（i）测量的非均匀计数密度分布和（ii）用于校准NM成像系统的建模或计算的不均匀计数密度分布导出的伽马相机均匀性校正图。
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公开(公告)号：US20080237476A1
公开(公告)日：2008-10-02
申请号：US11731883
申请日：2007-03-30
CPC分类号： G01T1/1648 , G01T1/1611 , G21K1/04
摘要： Embodiments relate to pinhole collimator assemblies having one or more adjustable size pinhole apertures therein. The pinhole collimator assembly is configured so that gamma rays can pass through the collimator assembly, but the remainder of the collimator assembly is substantially gamma ray absorbent. Embodiments also relate to imaging systems and methods of adjusting pinhole collimator performance.
摘要翻译： 实施例涉及其中具有一个或多个可调节尺寸的针孔的针孔准直器组件。 针孔准直器组件被配置成使γ射线可以通过准直器组件，但准直器组件的其余部分基本上是γ射线吸收剂。 实施例还涉及成像系统和调整针孔准直器性能的方法。
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公开(公告)号：US20080142719A1
公开(公告)日：2008-06-19
申请号：US11639786
申请日：2006-12-15
IPC分类号： G01T1/166
摘要： Collimator assemblies that include an outer slit collimator having one or more slits therein, and an inner slit collimator having one or more slits therein are provided. Imaging systems that include a collimator assembly and a detector array are also provided. The collimator assembly includes an outer slit collimator having one or more slits therein. The collimator assembly further includes an inner slit collimator having one or more slits therein. The imaging system also includes a detector array configured to detect gamma rays emanating from a field of view that pass through one or more apertures defined by the collimator assembly. The detector array is further configured to generate one or more signals in response to the detected gamma rays. Methods of imaging a field of view using the imaging system are also provided.
摘要翻译： 包括其中具有一个或多个狭缝的外部狭缝准直器和其中具有一个或多个狭缝的内部狭缝准直器的准直器组件。 还提供了包括准直器组件和检测器阵列的成像系统。 准直器组件包括其中具有一个或多个狭缝的外部狭缝准直器。 准直器组件还包括其中具有一个或多个狭缝的内部狭缝准直器。 成像系统还包括检测器阵列，其被配置为检测从通过由准直器组件限定的一个或多个孔的视场发出的伽马射线。 检测器阵列还被配置为响应于检测到的伽马射线产生一个或多个信号。 还提供了使用成像系统对视场进行成像的方法。
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公开(公告)号：US09129426B2
公开(公告)日：2015-09-08
申请号：US12873039
申请日：2010-08-31
申请人： Girishankar Gopalakrishnan , Alexander Ganin , Ravindra Mohan Majeshwar , Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Floribertus P.M. Heukensfeldt Jansen , Arunabha Shasanka Roy
发明人： Girishankar Gopalakrishnan , Alexander Ganin , Ravindra Mohan Majeshwar , Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Floribertus P.M. Heukensfeldt Jansen , Arunabha Shasanka Roy
CPC分类号： G06T7/38 , G06T5/002 , G06T5/40 , G06T5/50 , G06T7/20 , G06T7/269 , G06T7/30 , G06T11/005 , G06T2207/10016 , G06T2207/10104 , G06T2207/10108 , G06T2207/20221 , G06T2207/30004 , G06T2211/412
摘要： Methods and systems for processing a set of images are described. In accordance with this disclosure, images are registered and an analysis is performed in view of one or more constraints (such as constraints based upon anatomical or physiological considerations). Weighting factors are determined based on the analysis. The weighting factors are used in subsequent processing of the registered (and/or unregistered) images and/or to formulate a visualization that conveys the degree of confidence in the motion estimation used in the registration process.
摘要翻译： 描述用于处理一组图像的方法和系统。 根据本公开，记录图像，并且根据一个或多个约束（诸如基于解剖学或生理考虑的约束）来执行分析。 加权因子根据分析确定。 加权因子用于后续的注册（和/或未注册）图像的处理和/或制定传达在注册过程中使用的运动估计中的置信度的可视化。
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公开(公告)号：US20130161520A1
公开(公告)日：2013-06-27
申请号：US13333542
申请日：2011-12-21
CPC分类号： A61B6/037 , A61B6/4291 , A61B6/584 , A61B6/585 , G01T1/1648 , G21K1/02 , Y10T29/49016
摘要： A system and method for collimation in imaging systems are provided. One system includes a collimator a collimator body and at least one set of pinholes within the collimator body defining a cluster of pinholes, wherein bores defining the pinholes within the cluster are aligned to a point in substantially the same direction. Additionally, a spacing between bores is less than four times a diameter of a largest bore.
摘要翻译： 提供了一种用于成像系统中准直的系统和方法。 一个系统包括准直器准直器主体和准直器主体内的至少一组针孔，其限定一组针孔，其中限定该群集内的针孔的孔与基本上相同方向的点对齐。 此外，孔之间的间距小于最大孔的直径的四倍。
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公开(公告)号：US20120305781A1
公开(公告)日：2012-12-06
申请号：US13149417
申请日：2011-05-31
CPC分类号： G21K1/02 , G02B27/30 , G21K1/025 , Y10T29/49826
摘要： A system and method for collimation in diagnostic imaging systems is provided. One collimator includes a plurality of parallel hole segments and a plurality of collimator bores within each of the plurality of parallel hole segments. Additionally, all of the plurality of collimator bores in at least one of the plurality of parallel hole segments have a first pointing direction and all of the plurality of collimator bores in at least one other of the plurality of parallel hole segments have a second pointing direction, wherein the plurality of parallel hole segments are arranged in a fanbeam collimation configuration. Further, the first pointing direction is different than the second pointing direction.
摘要翻译： 提供了诊断成像系统中准直的系统和方法。 一个准直器包括在多个平行孔段的每一个内的多个平行孔段和多个准直器孔。 此外，多个平行孔段中的至少一个中的所有多个准直器孔具有第一指向方向，并且多个平行孔段中的至少另一个中的所述多个准直器孔中的所有多个准直器孔具有第二指向方向 ，其中所述多个平行孔段以风扇光束准直配置布置。 此外，第一指向方向与第二指示方向不同。
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9.发明申请METHOD AND SYSTEM OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM 失效光学成像技术在散射介质中的目标检测方法与系统公开(公告)号：US20080296482A1
公开(公告)日：2008-12-04
申请号：US11756135
申请日：2007-05-31
申请人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
发明人： Deborah Stutz Lee , Kajoli Banerjee Krishnan , Siavash Yazdanfar , Stephen Johnson Lomnes , Floribertus P.M. Heukensfeldt Jansen , Stephen Andrew Latham
IPC分类号： H01J40/14
CPC分类号： A61B5/0059
摘要： A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.
摘要翻译： 提供了一种用于包括散射介质的受试者中的靶的荧光成像的方法和系统。 该方法包括使用照明源照射散射介质的表面上的一个或多个点，其中多个点限定照明区域，收集来自照明区域的发射光和远离照明区域的区域，以及生成图像 的散射介质。
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公开(公告)号：US20130126744A1
公开(公告)日：2013-05-23
申请号：US13304248
申请日：2011-11-23
CPC分类号： H01L31/085 , A61B6/037 , A61B6/06 , A61B6/42
摘要： Imaging detectors and methods of manufacturing are provided. One imaging detector includes a first detector layer within a detector module and a second detector layer within the detector module and spaced apart from the first detector layer, wherein the second detector layer has an opening therethrough. The imaging detector also includes a collimator mounted to the detector module, wherein the collimator is one of a single pinhole collimator or a multi-pinhole collimator. Additionally, the second detector layer is mounted within the detector module closer to an opening of the collimator than the first detector layer.
摘要翻译： 提供成像探测器和制造方法。 一个成像检测器包括检测器模块内的第一检测器层和检测器模块内的第二检测器层并且与第一检测器层间隔开，其中第二检测器层具有穿过其中的开口。 成像检测器还包括安装到检测器模块的准直器，其中准直器是单个针孔准直仪或多针孔准直仪之一。 此外，第二检测器层安装在检测器模块内比第一检测器层更靠近准直仪的开口。
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