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公开(公告)号：US08809371B2
公开(公告)日：2014-08-19
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
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公开(公告)号：US20100092730A1
公开(公告)日：2010-04-15
申请号：US12519893
申请日：2007-12-21
CPC分类号： C09J7/22 , Y10T428/24521 , Y10T428/24562
摘要： An adhesive sheet which can be produced without using a release sheet having an uneven surface form and which can prevent or remove air bubbles and blisters and a process for producing the same are provided by an adhesive sheet prepared by laminating a non-permeable adhesive layer in which both surfaces are flat on an uneven surface of a base material having concave and convex parts in which adjacent concave parts are communicated with each other at least on one surface so that the adhesive layer is brought into contact with the convex part of the base material and a process comprising laminating a release sheet provided on a release treated surface with a non-permeable adhesive layer in which both surfaces are flat and a base material having concave and convex parts in which adjacent concave parts are communicated with each other at least on one surface so that the non-permeable adhesive layer is brought into contact with the convex part of the base material.
摘要翻译： 可以不使用具有不平坦表面形状并且可以防止或去除气泡和起泡的剥离片而制造的粘合片及其制造方法由通过将不透水性粘合剂层层压在 所述两个表面在具有凹凸部的基材的凹凸表面上是平坦的，其中相邻的凹部至少在一个表面上彼此连通，使得粘合剂层与基材的凸部接触 以及包括将设置在脱模处理表面上的剥离片层压到其两面平坦的不渗透性粘合剂层和具有凹凸部的基材的工序，相邻的凹部至少在一个上彼此连通 使得不渗透性粘合剂层与基材的凸部接触。
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公开(公告)号：US08895585B2
公开(公告)日：2014-11-25
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
CPC分类号： C07D401/12 , C07D213/82 , C07D215/40 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/107 , C07D498/04 , C07D513/04
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
摘要翻译： 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 本发明提供下述式（I）表示的烟酰胺衍生物（其中，R1表示卤素原子，R2表示C1-12烷基，C2-12烯基，C2-12炔基，C3-8 环烷基，芳基，芳基-C 1-6烷基或杂环基，各自任选具有至少一个取代基; R 3表示各自任选具有至少一个取代基的芳基或杂环基;以及R 4和R 5各自 独立地表示氢原子; R2和R4可以形成任选具有至少一个取代基的环状氨基以及与它们结合的氮原子）或其盐，以及用于治疗Syk- 其包含烟酰胺衍生物或其盐。
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公开(公告)号：US20130116430A1
公开(公告)日：2013-05-09
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu FUJIWARA , Kimihiko SATO , Shinsuke MIZUMOTO , Yuichiro SATO , Hideki KURIHARA , Yohei KUBO , Hiyoku NAKATA , Yasutaka BABA , Takashi TAMURA , Hidenobu KUNIYOSHI , Shinji HAGIWARA , Mari YAMAMOTO
发明人： Hideyasu FUJIWARA , Kimihiko SATO , Shinsuke MIZUMOTO , Yuichiro SATO , Hideki KURIHARA , Yohei KUBO , Hiyoku NAKATA , Yasutaka BABA , Takashi TAMURA , Hidenobu KUNIYOSHI , Shinji HAGIWARA , Mari YAMAMOTO
IPC分类号： C07D401/12 , C07D401/04 , C07D213/82 , C07D513/04 , C07D413/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D401/14 , C07D471/04
CPC分类号： C07D401/12 , C07D213/82 , C07D215/40 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/107 , C07D498/04 , C07D513/04
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
摘要翻译： 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 本发明提供下述式（I）表示的烟酰胺衍生物（其中，R1表示卤素原子，R2表示C1-12烷基，C2-12烯基，C2-12炔基，C3-8 环烷基，芳基，芳基-C 1-6烷基或杂环基，各自任选具有至少一个取代基; R 3表示各自任选具有至少一个取代基的芳基或杂环基;以及R 4和R 5各自 独立地表示氢原子; R2和R4可以形成任选具有至少一个取代基的环状氨基以及与它们结合的氮原子）或其盐，以及用于治疗Syk- 其包含烟酰胺衍生物或其盐。
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公开(公告)号：US08772320B2
公开(公告)日：2014-07-08
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
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公开(公告)号：US5490573A
公开(公告)日：1996-02-13
申请号：US310323
申请日：1994-09-22
CPC分类号： F02D9/1095 , B62J17/00 , F02M35/10013 , F02M35/162 , F02D2009/0254 , F02D2009/0279 , F02M35/10216 , F02M35/116
摘要： A pair of air inlet openings and a pair of air introduction paths are formed in a leftwardly and rightwardly symmetrical relationship on left and right side portions of a windshield. The air introduction paths are each formed as a smooth continuous curved face in a transverse direction, and a body center side curved face of the air introduction path is formed more moderate relative to an outer side curved face. When surface air flows along the surface of the front face flow on the air introduction paths since the body center side curved faces are moderate, exfoliation occurs less likely, and the external air admission efficiency of the air inlet openings is raised.
摘要翻译： 一对空气入口和一对空气引入通道在挡风玻璃的左侧和右侧部分上以左右对称的关系形成。 空气导入路径分别在横向上形成为平滑的连续曲面，并且空气导入路径的体心侧弯曲面相对于外侧曲面形成得更加适中。 当空气导入路径中的表面空气流经空气导入路径的表面空气流动时，由于体心侧弯曲面适中，所以不易发生剥离，进气口的外部空气进入效率提高。
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7.发明申请公开(公告)号：US20110014411A1
公开(公告)日：2011-01-20
申请号：US12922881
申请日：2009-03-17
申请人： Shinji Hagiwara , Toshimitsu Kanda
发明人： Shinji Hagiwara , Toshimitsu Kanda
CPC分类号： C09J7/38 , C09J2201/28 , Y10T428/1476 , Y10T428/2457 , Y10T428/24612
摘要： The present invention disclose a pressure-sensitive adhesive sheet having the adhesive layer on at least one surface of the substrate, characterized in that in particular the above adhesive layer has a number of trunk-like grooves which lead to the end of the above sheet, and a number of branch-like grooves with closed terminals which branch from the trunk-like grooves. This structure provides effects in that it can be applied easily and smoothly without retaining air when adhering to an adherend and additionally the appearance of the pressure-sensitive adhesive sheet is not damaged after adhering.
摘要翻译： 本发明公开了一种在基材的至少一个表面上具有粘合剂层的压敏粘合片，其特征在于，特别地，上述粘合剂层具有导致上述片材末端的多个躯干状凹槽， 以及多个具有从躯干状槽分支的封闭端子的分支状沟槽。 这种结构提供了这样的效果，即，当粘合到被粘物上时，可以容易且顺利地使用而不会留空，另外粘合后的粘合片的外观也不会受损。
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