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公开(公告)号：US08895585B2
公开(公告)日：2014-11-25
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
CPC分类号： C07D401/12 , C07D213/82 , C07D215/40 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/107 , C07D498/04 , C07D513/04
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
摘要翻译： 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 本发明提供下述式（I）表示的烟酰胺衍生物（其中，R1表示卤素原子，R2表示C1-12烷基，C2-12烯基，C2-12炔基，C3-8 环烷基，芳基，芳基-C 1-6烷基或杂环基，各自任选具有至少一个取代基; R 3表示各自任选具有至少一个取代基的芳基或杂环基;以及R 4和R 5各自 独立地表示氢原子; R2和R4可以形成任选具有至少一个取代基的环状氨基以及与它们结合的氮原子）或其盐，以及用于治疗Syk- 其包含烟酰胺衍生物或其盐。
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公开(公告)号：US20130116430A1
公开(公告)日：2013-05-09
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu FUJIWARA , Kimihiko SATO , Shinsuke MIZUMOTO , Yuichiro SATO , Hideki KURIHARA , Yohei KUBO , Hiyoku NAKATA , Yasutaka BABA , Takashi TAMURA , Hidenobu KUNIYOSHI , Shinji HAGIWARA , Mari YAMAMOTO
发明人： Hideyasu FUJIWARA , Kimihiko SATO , Shinsuke MIZUMOTO , Yuichiro SATO , Hideki KURIHARA , Yohei KUBO , Hiyoku NAKATA , Yasutaka BABA , Takashi TAMURA , Hidenobu KUNIYOSHI , Shinji HAGIWARA , Mari YAMAMOTO
IPC分类号： C07D401/12 , C07D401/04 , C07D213/82 , C07D513/04 , C07D413/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D401/14 , C07D471/04
CPC分类号： C07D401/12 , C07D213/82 , C07D215/40 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/107 , C07D498/04 , C07D513/04
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
摘要翻译： 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 本发明提供下述式（I）表示的烟酰胺衍生物（其中，R1表示卤素原子，R2表示C1-12烷基，C2-12烯基，C2-12炔基，C3-8 环烷基，芳基，芳基-C 1-6烷基或杂环基，各自任选具有至少一个取代基; R 3表示各自任选具有至少一个取代基的芳基或杂环基;以及R 4和R 5各自 独立地表示氢原子; R2和R4可以形成任选具有至少一个取代基的环状氨基以及与它们结合的氮原子）或其盐，以及用于治疗Syk- 其包含烟酰胺衍生物或其盐。
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公开(公告)号：US08809371B2
公开(公告)日：2014-08-19
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
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公开(公告)号：US08772320B2
公开(公告)日：2014-07-08
申请号：US13730000
申请日：2012-12-28
申请人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
发明人： Hideyasu Fujiwara , Kimihiko Sato , Shinsuke Mizumoto , Yuichiro Sato , Hideki Kurihara , Yohei Kubo , Hiyoku Nakata , Yasutaka Baba , Takashi Tamura , Hidenobu Kuniyoshi , Shinji Hagiwara , Mari Yamamoto
IPC分类号： C07D213/82
摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
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公开(公告)号：US20090081377A1
公开(公告)日：2009-03-26
申请号：US12237453
申请日：2008-09-25
申请人： Yohei KUBO
发明人： Yohei KUBO
CPC分类号： C08F2/48 , C08G2261/312 , C08K5/0025 , C08L65/00
摘要： A film-forming composition, includes: a photoacid generator; and a crosslinked or crosslinkable polyphenylene that is a product of a Diels-Alder reaction between at least one kind of a compound having two or more diene functional groups and at least one kind of a compound having two or more dienophile functional groups, in which at least one of the compounds has three functional groups as the functional group, and a method for producing a film, includes: applying the film-forming composition to a substrate; and irradiating the applied composition with an electron beam or an electromagnetic wave at a wavelength larger than 200 nm.
摘要翻译： 成膜组合物包括：光致酸产生剂; 以及交联或交联的聚亚苯，其是至少一种具有两个或更多个二烯官能团的化合物和至少一种具有两个或更多个亲二烯体官能团的化合物之间的Diels-Alder反应的产物，其中在 至少一种化合物具有三个官能团作为官能团，以及膜的制造方法，包括：将成膜组合物涂布在基材上; 并用大于200nm的波长的电子束或电磁波照射施加的组合物。
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