公开(公告)号：US08933122B2

公开(公告)日：2015-01-13

申请号：US13000383

申请日：2009-06-30

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

IPC: A61L101/36 ,  A61L2/16 ,  A01N37/44 ,  A01N37/46 ,  A01P1/00 ,  A01P3/00 ,  A01N47/44 ,  A01N43/50 ,  A23L3/3463 ,  A23L3/3499 ,  A23L3/3517 ,  A23L3/3526 ,  C11D1/10 ,  C11D3/48 ,  A61L2/18

CPC classification number: A01N47/44 ,  A01N37/46 ,  A01N43/50 ,  A23L3/3463 ,  A23L3/3499 ,  A23L3/3517 ,  A23L3/3526 ,  A61L2/18 ,  C11D1/10 ,  C11D3/48

Abstract: Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the treatment of objects which are infected with spores. The spores may originate from bacteria or fungi.

Abstract translation: 衍生自脂肪酸和酯化二元氨基酸（例如月桂酸和精氨酸）的缩合的阳离子表面活性剂，特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯可用于治疗被感染的物体 与孢子。 孢子可能来源于细菌或真菌。

公开(公告)号：US20110275714A1

公开(公告)日：2011-11-10

申请号：US13144975

申请日：2010-01-12

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca

IPC: A01N37/44 ,  A01P7/02

CPC classification number: A01N43/50 ,  A01N37/30 ,  A01N47/44 ,  A23B4/20 ,  A23L3/3463 ,  A23L3/3526 ,  A61K31/216 ,  A61K31/4164

Abstract: This invention relates to a use of a composition for protecting against mites and ticks containing cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCl (LAE). It has been found that cationic surfactants such as ethyl-Nα-lauroyl-L-arginate HCl (LAE) and its salts are effective acaricidal agents.

Abstract translation: 本发明涉及用于防止含有阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）的螨虫和蜱的组合物的用途。 已经发现，阳离子表面活性剂如乙基-Nα-月桂酰-L-精氨酸盐酸盐（LAE）及其盐是有效的杀螨剂。

公开(公告)号：US20090326031A1

公开(公告)日：2009-12-31

申请号：US12375774

申请日：2006-08-03

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons

IPC: A61K31/221 ,  A61K31/4164 ,  A61P31/12

CPC classification number: A61K31/155 ,  A23L3/3463 ,  A23L3/3526 ,  A61K31/223 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/18 ,  A61L2/23 ,  C02F1/50 ,  C02F2305/04 ,  C11D1/50 ,  C11D1/58 ,  C11D3/48

Abstract: Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the protection against the growth of the microorganisms. The cationic surfactants of this type are also effective against virus infections. Addition of LAE to cultures of Herpes virus type 1 Vaccinia virus and bovine parainfluenzae 3 virus leads to nearly complete reduction of the virus organisms in these cultures, such effects being observed after 5 and 60 minutes.

Abstract translation: 衍生自脂肪酸和酯化的二元氨基酸（例如月桂酸和精氨酸），特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯的缩合产生的阳离子表面活性剂可用于防止生长 微生物。 这种阳离子表面活性剂对于病毒感染也是有效的。 在1型疱疹病毒和牛副流感病毒3病毒的培养物中添加LAE导致这些培养物中病毒生物体的几乎完全减少，在5和60分钟后观察到这种效应。

公开(公告)号：US20100305055A1

公开(公告)日：2010-12-02

申请号：US12675823

申请日：2007-10-05

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

IPC: A01N43/24 ,  A01P3/00 ,  A61P31/10 ,  A61K31/7048

CPC classification number: A23B4/22 ,  A01N43/90 ,  A23B4/20 ,  A23C19/11 ,  A23L3/3463 ,  A23L3/34635 ,  A01N2300/00

Abstract: A solid composition comprising a cationic surfactant, such as the ethyl ester of the lauramide of the arginine mono-hydrochloride (LAE) and a polyene fungicide such as natamycin is provided. The solid composition is the basis for providing solutions of natamycin of increased concentration. The solid composition may be used for providing a dispersion of natamycin in a suitable liquid, such as tap water or an organic solvent. The dispersion may be further diluted with water. This leads to a solution of natamycin in water. The combination of the cationic surfactant and the polyene fungicide displays a biological effect which is stronger than the effect of each of the two components alone.

Abstract translation: 提供了包含阳离子表面活性剂，例如精氨酸单盐酸盐（LAE）的月桂酰胺的乙酯和多奈杀真菌剂如游霉素的固体组合物。 固体组合物是提供增加浓度的那他霉素溶液的基础。 固体组合物可用于提供游霉素在合适的液体如自来水或有机溶剂中的分散体。 分散体可以进一步用水稀释。 这导致游霉素在水中的溶液。 阳离子表面活性剂和多烯杀真菌剂的组合显示比单独的两种组分中的每一种的效果更强的生物效应。

公开(公告)号：US10130830B2

公开(公告)日：2018-11-20

申请号：US11997160

申请日：2005-08-01

Applicant: Jordi Miret Carceller ,  Sergi Figueras Roca ,  Roger Segret Pons

Inventor： Jordi Miret Carceller ,  Sergi Figueras Roca ,  Roger Segret Pons

IPC: A61Q19/10 ,  A23B4/20 ,  A23B4/24 ,  A23B7/154 ,  A23B7/157 ,  A23L3/3508 ,  A23L3/3517 ,  A23L3/3526 ,  A23L3/3544 ,  A23L3/358 ,  A61K8/44 ,  A61K8/49 ,  A61Q19/00

Abstract: Preservative systems on the basis of cationic surfactants are known i n the art, a typical example of such cationic surfactants is the ethyl ester of the lauramide of arginine monohydrochloride (LAE) (2). Besides the chloride form the corresponding bromide and sulphate salts are known. It was found that other salts of the cationic surfactants display excellent properties, such as the salts of lactic acid, glutamic acid and acetic acid. It was further found that the combination of the cationic surfactants with at least one salt of an organic or inorganic acid displayed an excellent preservative action. A further preservative system with favourable properties was the combination of the cationic surfactants with at least one ester compound, amide or enzyme inhibitor. Also the combination of the cationic surfactant with a further cationic molecule such as ethyl arginate, glucosamine or chitosan led to an effective preservative system. A further effective preservative system turned out to be the cationic surfactant in encapsulated form.

公开(公告)号：US20110144203A1

公开(公告)日：2011-06-16

申请号：US13000383

申请日：2009-06-30

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

IPC: A01N37/44 ,  A01P1/00 ,  A01P3/00

CPC classification number: A01N47/44 ,  A01N37/46 ,  A01N43/50 ,  A23L3/3463 ,  A23L3/3499 ,  A23L3/3517 ,  A23L3/3526 ,  A61L2/18 ,  C11D1/10 ,  C11D3/48

Abstract: Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the treatment of objects which are infected with spores. The spores may originate from bacteria or fungi.

Abstract translation: 衍生自脂肪酸和酯化二元氨基酸（例如月桂酸和精氨酸）的缩合的阳离子表面活性剂，特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯可用于治疗被感染的物体 与孢子。 孢子可能来源于细菌或真菌。

公开(公告)号：US07074447B2

公开(公告)日：2006-07-11

申请号：US10475544

申请日：2001-04-28

Applicant: Joan Seguer Bonaventura ,  Sergi Figueras Roca ,  Joan Bta. Urgell Beltran

Inventor： Joan Seguer Bonaventura ,  Sergi Figueras Roca ,  Joan Bta. Urgell Beltran

IPC: A23L3/34 ,  A23L3/3409

CPC classification number: A01N47/44 ,  A01N37/04 ,  A01N2300/00

Abstract: The invention relates to a novel composition with antimicrobial activity. It is in the food industry a well-known method to use the product L-arginine, Na-lauroyl-ethylester monohydrochloride (LAE). This product is well tolerated and suitable for use in the preservation of all perishable food products. The action of LAE can be further improved by combining the product with a second component selected from the group consisting of potassium sorbate, sodium sorbate and sorbic acid. The weight ratio of LAE to the second component is preferably in the range of 1:50 to 50:1. The combination of the two products leads to a synergistic combined activity against such microorganisms as Bacillus subtilis, Staphylococcus aureus, Bacillus megaterium, Citrobacter intermedium, Enterobacter aerogenes, Escherichia coli, Candida albicans, Penicillium camemberti and Cladosporium cladosporioides.

Abstract translation: 本发明涉及具有抗菌活性的新型组合物。 在食品工业中使用L-精氨酸，月桂酰 - 乙酯单盐酸盐（LAE）的公知方法。 该产品耐受性好，适用于保存所有易腐食品。 通过将产物与选自山梨酸钾，山梨酸钾和山梨酸的第二组分组合，可进一步提高LAE的作用。 LAE与第二组分的重量比优选在1:50至50:1的范围内。 两种产品的组合导致与枯草芽孢杆菌，金黄色葡萄球菌，巨大芽孢杆菌，柠檬酸杆菌介质，产气肠杆菌，大肠杆菌，白色念珠菌，青霉菌和枝孢杆菌等微生物的协同组合活性。

公开(公告)号：US20100028325A1

公开(公告)日：2010-02-04

申请号：US12525718

申请日：2007-02-07

Applicant: Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

Inventor： Xavier Rocabayera Bonvila ,  Sergi Figueras Roca ,  Roger Segret Pons ,  Eva Piera Eroles

IPC: A01N63/00 ,  A01N37/12 ,  A01P1/00

CPC classification number: A61K8/44 ,  A23L2/44 ,  A23L2/56 ,  A23L2/60 ,  A23L3/3526 ,  A23L3/3544 ,  A23L27/20 ,  A23L27/30 ,  A23L27/84 ,  A23L27/86 ,  A23V2002/00 ,  A61K2800/524 ,  A61Q11/00 ,  A23V2200/16 ,  A23V2250/264 ,  A23V2200/10 ,  A23V2250/06 ,  A23V2250/24

Abstract: Use of cationic surfactants, derived from the condensation of fatty acids and esterified dibasic amino acids, of the formula (1): occasionally leads to a bitter taste, when the compound is present in a large concentration. The bitter taste can be masked by combination with a second component selected from the list consisting of sucralose, neohespiridin (NHDC), β-cyclodextrin, mono ammonium glycyrrhizinate (MAG), banana, mentholyptus, sodium dodecyl sulphate (SDS), anetol, menthol, thaumatin, adenosine monophosphate (AMP), aloten, arginine, sodium acetate, arilic acids (ferulic acid, caffeic acid), sclareolide, maltol, anane, phosphatidic acid, eucalyptol, lactisole, lysozyme, lactoglobulin, timol, borneol, acetol, phosphothreonine, phosphotyrosine, phosphoserine, Masking flavour 501521T, Masking flavour 501522, saccharine, aspartame, MK22 N&A FL for masking #25682, MM24 Prosweet N&A FL Enhancer, neodiosmin, xylitol, stevia and Natural and Functional Flavour (NAF®).

Abstract translation: 使用衍生自式（1）的脂肪酸和酯化的二元氨基酸缩合的阳离子表面活性剂：当化合物以大的浓度存在时，偶尔会导致苦味。 可以通过与选自三氯半乳蔗糖，新氯皮质素（NHDC），β-环糊精，甘草酸单铵（MAG），香蕉，薄荷醇，十二烷基硫酸钠（SDS），茴香醚，薄荷醇的列表组合的第二组分的组合掩蔽苦味 ，马齿苋，阿魏酸，磷脂酸，桉油醇，乳清蛋白，溶菌酶，乳球蛋白，酪醇，冰片，丙酮醇，磷酸苏氨酸，阿托品酸，阿魏酸，阿魏酸， ，磷酸丝氨酸，掩蔽调味剂501521T，掩蔽香料501522，糖精，阿斯巴甜，MK22 N＆A FL掩蔽＃25682，MM24 Prosweet N＆A FL Enhancer，neodiosmin，木糖醇，甜菊和天然和功能性香料（NAF）。

公开(公告)号：US20100092420A1

公开(公告)日：2010-04-15

申请号：US11997160

申请日：2005-08-01

Applicant: Jordi Miret Carceller ,  Sergi Figueras Roca ,  Roger Segret Pons

Inventor： Jordi Miret Carceller ,  Sergi Figueras Roca ,  Roger Segret Pons

IPC: A23L3/3463 ,  C07C229/04 ,  A01N37/12 ,  A01N37/18 ,  A01N43/04 ,  A01P1/00 ,  A61K8/18 ,  A61K8/81 ,  A61K8/73

CPC classification number: A61Q19/10 ,  A23B4/20 ,  A23B4/24 ,  A23B7/154 ,  A23B7/157 ,  A23L3/3508 ,  A23L3/3517 ,  A23L3/3526 ,  A23L3/3544 ,  A23L3/358 ,  A61K8/44 ,  A61K8/442 ,  A61K8/4946 ,  A61K2800/524 ,  A61Q19/00 ,  Y02A40/944

Abstract: Preservative systems on the basis of cationic surfactants are known i n the art, a typical example of such cationic surfactants is the ethyl ester of the lauramide of arginine monohydrochloride (LAE) (2). Besides the chloride form the corresponding bromide and sulphate salts are known. It was found that other salts of the cationic surfactants display excellent properties, such as the salts of lactic acid, glutamic acid and acetic acid. It was further found that the combination of the cationic surfactants with at least one salt of an organic or inorganic acid displayed an excellent preservative action. A further preservative system with favourable properties was the combination of the cationic surfactants with at least one ester compound, amide or enzyme inhibitor. Also the combination of the cationic surfactant with a further cationic molecule such as ethyl arginate, glucosamine or chitosan led to an effective preservative system. A further effective preservative system turned out to be the cationic surfactant in encapsulated form.

Abstract translation: 基于阳离子表面活性剂的防腐剂体系是本领域已知的，这种阳离子表面活性剂的典型实例是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯（2）。 除了氯化物形式之外，已知相应的溴化物和硫酸盐。 发现阳离子表面活性剂的其它盐显示出优异的性质，例如乳酸，谷氨酸和乙酸的盐。 进一步发现阳离子表面活性剂与有机或无机酸的至少一种盐的组合显示出优异的防腐作用。 阳离子表面活性剂与至少一种酯化合物，酰胺或酶抑制剂的组合具有良好性能的另外的防腐剂体系。 此外，阳离子表面活性剂与另外的阳离子分子如精氨酸乙酯，葡糖胺或壳聚糖的组合导致有效的防腐剂体系。 另一种有效的防腐剂体系证明是封装形式的阳离子表面活性剂。