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    Monoamine re-uptake inhibitors and methods relating thereto
    2.
    发明申请
    Monoamine re-uptake inhibitors and methods relating thereto 审中-公开
    单胺再吸收抑制剂及其相关方法

    公开(公告)号：US20060252818A1

    公开(公告)日：2006-11-09

    申请号：US11429018

    申请日：2006-05-05

    申请人： Mehrak Kiankarimi ,  Sarah Hudson ,  Wesley Dwight ,  Warren Wade

    发明人： Mehrak Kiankarimi ,  Sarah Hudson ,  Wesley Dwight ,  Warren Wade

    IPC分类号： A61K31/382 ,  A61K31/353 ,  C07D335/06

    CPC分类号： C07D335/06 ,  C07D307/83 ,  C07D311/22 ,  C07D311/76 ,  C07D407/12 ,  C07D409/12

    摘要： Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3, R4, R5, R6, m, n, W, X, and Y are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.

    摘要翻译： 公开了单胺再摄取抑制剂，更具体地说可用于治疗男性和女性中枢或周围神经系统疾病的5-羟色胺和去甲肾上腺素再摄取抑制剂。 本发明的化合物具有以下结构：其中R 1，R 2，R 3，R 4， R 5，R 6，m，n，W，X​​和Y如本文所定义，包括立体异构体，前药及其药学上可接受的盐，酯和溶剂化物。 还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中抑制单胺再摄取的方法。