发明授权
- 专利标题： TGR5 agonists
- 专利标题（中）： TGR5激动剂
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申请号： US13515132申请日： 2010-08-11
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公开(公告)号： US08846739B2公开(公告)日： 2014-09-30
- 发明人: Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt
- 申请人： Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt
- 申请人地址： US CA South San Francisco
- 专利权人： Exelixis Patent Company LLC
- 当前专利权人： Exelixis Patent Company LLC
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Heidi Berven; Jonathan P. O'Brien
- 国际申请： PCT/US2010/045195 WO 20100811
- 国际公布： WO2011/071565 WO 20110616
- 主分类号： C07D249/10
- IPC分类号： C07D249/10 ; C07D249/08 ; C07D233/54 ; C07D401/12 ; A61K31/454 ; A61K31/496 ; A61K31/4995 ; C07D295/15 ; C07D249/12 ; A61K31/4164 ; A61K31/4178 ; A61K31/5377 ; A61K31/4196 ; C07D403/12 ; C07D233/64 ; C07D233/84 ; A61K31/4439 ; C07D487/08
摘要：
TGR5 agonists of structural formula VIII(Q), wherein X, R1, R2, and R5 are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.
公开/授权文献
- US20130303505A1 TGR5 AGONISTS 公开/授权日：2013-11-14
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