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公开(公告)号：US20240091358A1
公开(公告)日：2024-03-21
申请号：US18352079
申请日：2023-07-13
CPC分类号： A61K39/4635 , C07K14/5428 , C07K14/5434 , C12N15/86 , C07K2319/02 , C07K2319/03 , C07K2319/50 , C07K2319/95 , C12N2750/14143
摘要： Described herein are chimeric proteins including membrane-cleavable chimeric proteins and degron-fusion chimeric proteins. Also described herein are nucleic acids, pharmaceutical compositions, methods, and methods of treatment directed to the same.
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公开(公告)号：US20240058384A1
公开(公告)日：2024-02-22
申请号：US18501604
申请日：2023-11-03
发明人： Marcela Guzman Ayala
CPC分类号： A61K35/17 , C07K16/303 , A61P35/00 , A61K39/4611 , A61K39/4644 , A61K39/4613 , A61K2239/21 , A61K2239/22 , A61K2239/53 , A61K2239/13
摘要： The present disclosure provides compositions and methods related to chimeric antigen receptors (CARs). In particular, the present disclosure provides CAR-based immunotherapeutic compositions that target tumor cells expressing glypican-3 (GPC3) for the treatment and prevention of cancer.
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公开(公告)号：US20230272037A1
公开(公告)日：2023-08-31
申请号：US17820804
申请日：2022-08-18
IPC分类号： C07K14/725 , C07K14/705 , C07K14/47 , C12N15/63
CPC分类号： C07K14/7051 , C07K14/70596 , C07K14/4703 , C07K14/70521 , C12N15/63 , C07K2319/03 , C07K2319/02 , C07K2317/622 , C07K2317/55
摘要： Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
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公开(公告)号：US20230270789A1
公开(公告)日：2023-08-31
申请号：US17872827
申请日：2022-07-25
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang
IPC分类号： A61K35/28 , A61P35/00 , A61K39/395
CPC分类号： A61K35/28 , A61P35/00 , A61K39/3955 , A61K2039/5156
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US20210228640A1
公开(公告)日：2021-07-29
申请号：US17219569
申请日：2021-03-31
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , A61P35/00 , C07K14/715 , C12N5/0775 , C12N15/63
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US10993967B2
公开(公告)日：2021-05-04
申请号：US16656452
申请日：2019-10-17
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , A61P35/00 , C07K14/715 , C12N5/0775 , C12N15/63 , C07K16/28 , C07K16/30
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US20190233844A1
公开(公告)日：2019-08-01
申请号：US16319791
申请日：2017-07-26
发明人： Timothy Kuan-Ta LU , Remus WONG
IPC分类号： C12N15/86 , C12N15/62 , C12N15/113
CPC分类号： C12N15/85 , C12N5/0606 , C12N5/0607 , C12N5/0637 , C12N15/113 , C12N15/62 , C12N15/63 , C12N15/86 , C12N2310/122 , C12N2310/141 , C12N2310/20 , C12N2800/24 , C12N2800/30 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12Y301/21
摘要： Provided herein, in some embodiments, are methods, compositions, systems and kits that enable spatiotemporal regulation of nucleic acid expression in engineered cells.
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公开(公告)号：US20240277766A1
公开(公告)日：2024-08-22
申请号：US18541684
申请日：2023-12-15
发明人： Marcela GUZMAN AYALA , Russell Morrison GORDLEY , Michelle Elizabeth HUNG , Gary LEE , Timothy Kuan-Ta LU
CPC分类号： A61K35/17 , A61K9/0019 , A61K39/4613 , A61K39/4631 , A61K39/464402 , A61P35/00 , C07K14/5434 , C07K14/5443 , C07K16/303 , C12N5/0646 , A61K2239/13 , A61K2239/21 , C07K2317/622 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C12N2510/00
摘要： Described herein are immunoresponsive cells engineered to express cytokines, chimeric receptors, and synthetic transcription factor systems. Also described herein are nucleic acids, cells, and methods directed to the same.
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公开(公告)号：US20240277765A1
公开(公告)日：2024-08-22
申请号：US18501925
申请日：2023-11-03
发明人： Brian Scott Garrison , Jennifer Chien , Kathryn Armstrong Loving , Russell Morrison Gordley , Michelle Elizabeth Hung
IPC分类号： A61K35/17 , A61K38/00 , C07K14/725 , C07K16/28
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2803 , C07K16/2863 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2319/03
摘要： Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
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公开(公告)号：US20240226296A9
公开(公告)日：2024-07-11
申请号：US18377191
申请日：2023-10-05
发明人： Michelle Elizabeth Hung , Rebecca Tayler Cottman , Russell Morrison Gordley , Gary Lee , Timothy Kuan-Ta Lu , Srinivasaraghavan Kannan , Chandra Shekhar Verma
IPC分类号： A61K39/00
CPC分类号： A61K39/4635 , A61K39/4613 , A61K39/463
摘要： Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
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