公开(公告)号：US20240091358A1

公开(公告)日：2024-03-21

申请号：US18352079

申请日：2023-07-13

申请人： Senti Biosciences, Inc.

发明人： Michelle Elizabeth HUNG ,  Russell Morrison GORDLEY

IPC分类号： A61K39/00 ,  C07K14/54 ,  C12N15/86

CPC分类号： A61K39/4635 ,  C07K14/5428 ,  C07K14/5434 ,  C12N15/86 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/50 ,  C07K2319/95 ,  C12N2750/14143

摘要： Described herein are chimeric proteins including membrane-cleavable chimeric proteins and degron-fusion chimeric proteins. Also described herein are nucleic acids, pharmaceutical compositions, methods, and methods of treatment directed to the same.

公开(公告)号：US20240277766A1

公开(公告)日：2024-08-22

申请号：US18541684

申请日：2023-12-15

申请人： Senti Biosciences, Inc.

发明人： Marcela GUZMAN AYALA ,  Russell Morrison GORDLEY ,  Michelle Elizabeth HUNG ,  Gary LEE ,  Timothy Kuan-Ta LU

IPC分类号： A61K35/17 ,  A61K9/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/54 ,  C07K16/30 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K9/0019 ,  A61K39/4613 ,  A61K39/4631 ,  A61K39/464402 ,  A61P35/00 ,  C07K14/5434 ,  C07K14/5443 ,  C07K16/303 ,  C12N5/0646 ,  A61K2239/13 ,  A61K2239/21 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/50 ,  C12N2510/00

摘要： Described herein are immunoresponsive cells engineered to express cytokines, chimeric receptors, and synthetic transcription factor systems. Also described herein are nucleic acids, cells, and methods directed to the same.

公开(公告)号：US20240082303A1

公开(公告)日：2024-03-14

申请号：US18143338

申请日：2023-05-04

申请人： SENTI BIOSCIENCES, INC.

发明人： Michelle Elizabeth HUNG ,  Russell Morrison GORDLEY ,  Gary LEE

IPC分类号： A61K35/17 ,  A61K39/00 ,  C07K14/54

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4631 ,  A61K39/46444 ,  C07K14/5434 ,  C07K14/5443 ,  A61K2239/21 ,  A61K2239/22 ,  C07K2319/50

摘要： Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.

公开(公告)号：US20230405144A1

公开(公告)日：2023-12-21

申请号：US18199154

申请日：2023-05-18

申请人： Senti Biosciences, Inc.

发明人： Rocky CHEUNG ,  Russell Morrison GORDLEY ,  Timothy Kuan-Ta LU ,  Michelle Elizabeth HUNG ,  Rebecca Tayler COTTMAN

IPC分类号： A61K47/68 ,  A61K47/64 ,  A61K47/66

CPC分类号： A61K47/6897 ,  A61K47/64 ,  A61K47/6425 ,  A61K47/67 ,  A61K47/6815 ,  A61K47/6813 ,  A61K47/6829

摘要： Provided herein are compositions and methods for inducing cell death in a regulated manner, for example in a safety switch system. Inducible cell death can be triggered by ligand binding to a one or more ligand binding domains. Cell death can include induction of apoptosis.

公开(公告)号：US20230372486A1

公开(公告)日：2023-11-23

申请号：US18300981

申请日：2023-04-14

申请人： SENTI BIOSCIENCES, INC.

发明人： Brian Scott GARRISON ,  Michelle Elizabeth HUNG ,  Nicholas FRANKEL

IPC分类号： A61K39/00 ,  C07K16/30 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725

CPC分类号： A61K39/46447 ,  C07K16/3092 ,  A61P35/02 ,  A61K39/4613 ,  A61K39/4611 ,  A61K39/464416 ,  C07K14/70503 ,  C07K14/70521 ,  C07K14/7051 ,  A61K39/4621 ,  A61K39/4631 ,  C07K2317/622 ,  C07K2319/33 ,  A61K2239/28 ,  C07K2319/03 ,  A61K2239/48

摘要： Provided herein are EMCN-specific antigen-binding domains, and chimeric proteins including the EMCN-specific antigen-binding. Also provided herein are cells, nucleic acids, vectors, compositions, and methods directed to proteins including the EMCN-specific antigen-binding domains.