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公开(公告)号：US20120022296A1
公开(公告)日：2012-01-26
申请号：US13200691
申请日：2011-09-27
IPC分类号： C07C43/12
CPC分类号： C07C41/22 , C07C43/123
摘要： A method for the preparation of (CF3)2CHOCH2F (Sevoflurane) is presented, which comprises providing a mixture of (CF3)2CHOCH2Cl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF3)2CHOCH2F.
摘要翻译： 提供了制备（CF 3）2 CHOCH 2 F（七氟烷）的方法，其包括提供（CF 3）2 CHOCH 2 Cl，氟化钾，水和相转移催化剂的混合物，并使混合物反应形成（CF 3）2 CHOCH 2 F。
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2.发明授权Enamine quaternary compounds, methods of making and their use as muscle relaxants 失效将季铵化合物，制备方法及其作为肌肉松弛剂使用
公开(公告)号：US4863918A
公开(公告)日：1989-09-05
申请号：US221141
申请日：1988-07-19
申请人： Kanti J. Gala , Ross C. Terrell
发明人： Kanti J. Gala , Ross C. Terrell
IPC分类号： C07C251/20 , C07D209/54 , C07D211/14 , C07D211/18 , C07D211/44 , C07D211/58 , C07D211/60 , C07D211/70 , C07D211/74 , C07D217/10 , C07D217/16 , C07D223/04 , C07D223/16 , C07D295/096 , C07D307/52 , C07D317/28 , C07D333/22 , C07D409/12 , C07D491/10 , C07D491/22
CPC分类号： C07D295/096 , C07C251/20 , C07D209/54 , C07D211/14 , C07D211/18 , C07D211/44 , C07D211/58 , C07D211/60 , C07D211/70 , C07D211/74 , C07D217/10 , C07D217/16 , C07D223/04 , C07D223/16 , C07D307/52 , C07D317/28 , C07D333/22 , C07D409/12 , C07D491/10 , C07C2101/02 , C07C2101/14 , C07C2101/16
摘要： Disclosed are novel enamine quaternary compounds of the formula ##STR1## wherein m=1, 2 or 3 and n=1, 2 or 3 with the proviso that m+n=3, 4 or 5; R.sup.1 and R.sup.2 are independently lower alkyl or hydrogen, and R.sup.3 and R.sup.4 are independently selected from the group consisting of lower alkyl, lower cycloalkyl lower alkyl, lower alkenyl, phenyl lower alkyl, thienyl lower alkyl, furyl lower alkyl, lower alkoxy lower alkyl, halogenated lower alkyl, lower alkyloyloxo or lower alkyloyloxy lower alkyl or wherein NR.sup.3 R.sup.4 together comprise a heterocycle ring; and wherein X.sup.- represents a pharmaceutically acceptable anion. Pharmaceutical compositions containing the same when administered to warm-blooded animals exhibit a muscle relaxant effect characterized by excellent onset and recovery times. Also disclosed are methods of making the enamine quaternary compounds.
摘要翻译： 公开了下式的新型烯胺季化合物：其中m = 1,2或3，n = 1,2或3，条件是m + n = 3,4或5; R 1和R 2独立地为低级烷基或氢，R 3和R 4独立地选自低级烷基，低级环烷基低级烷基，低级烯基，苯基低级烷基，噻吩基低级烷基，呋喃基低级烷基，低级烷氧基低级烷基， 卤代低级烷基，低级烷氧基或低级烷氧基低级烷基，或其中NR 3 R 4一起构成杂环; 并且其中X代表药学上可接受的阴离子。 当对温血动物施用时，含有它们的药物组合物表现出以优异的起始和恢复时间为特征的肌肉松弛作用。 还公开了制备烯胺季铵化合物的方法。
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3.发明授权N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds 失效N-芳基-N-（4-哌啶基）酰胺和使用这些化合物的药物组合物和方法
公开(公告)号：US4584303A
公开(公告)日：1986-04-22
申请号：US707433
申请日：1985-04-17
IPC分类号： C07D211/58 , C07D211/66 , C07D401/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , A61K31/445 , C07D401/12 , C07D417/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/66 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04
摘要： Compounds are disclosed of the formula ##STR1## optically active isomeric forms thereof, and/or pharmaceutically acceptable acid addition salts thereof, in which formula: R is defined in the disclosure.
摘要翻译： 公开了具有式（I）的旋光异构体形式的化合物和/或其药学上可接受的酸加成盐，其中式R定义于本公开内容中。
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公开(公告)号：US3987111A
公开(公告)日：1976-10-19
申请号：US633763
申请日：1975-11-20
申请人： Ross C. Terrell
发明人： Ross C. Terrell
IPC分类号： C07C43/12
CPC分类号： C07C43/123
摘要： This disclosure is directed to novel ethers of the formula:CF.sub.3 CH.sub.a X.sub.b --O--CF.sub.2 CH.sub.c F.sub.d Cl.sub.ewherein X is fluorine, chlorine or bromine, preferably fluorine, a is 1 or 2, b is 0 or 1, a plus b are 2, preferably both a and b being 1, c is 0 or 1, d is 0 to 2, e is 0 to 2, c plus d plus e are 3, preferably each of c, d, and e is 1, and a plus c are 1 or 2, preferably 2, with the proviso that when e is 1 or 2, X is fluorine or bromine, preferably fluorine. The compounds having less than 8 fluorine atoms per molecule are useful as anesthetics, and all of the compounds are useful as solvents and dispersants for fluorinated materials. A highly preferred compound useful as an anesthetic is 1,2,2,2-tetrafluoroethyl 1',1',2'-trifluoro-2'-chloroethyl ether.
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公开(公告)号：US07202386B2
公开(公告)日：2007-04-10
申请号：US10644500
申请日：2003-08-20
申请人： Ross C. Terrell
发明人： Ross C. Terrell
IPC分类号： C07C41/22
CPC分类号： C07C41/22 , C07C43/123
摘要： A method for the preparation of sevoflurane which comprises (a) providing a liquid mixture of (CF3)2CHOCH2Cl, hydrogen fluoride, and an amine and (b) reacting the mixture, to form (CF3)2CHOCH2F.
摘要翻译： 一种用于制备七氟烷的方法，其包括（a）提供（CF 3 3）2 CH 2 CH 2 Cl的液体混合物，氟化氢， 和胺，和（b）使混合物反应，形成（CF 3）2 CHOCH 2 F。
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公开(公告)号：US4017519A
公开(公告)日：1977-04-12
申请号：US616351
申请日：1975-09-24
申请人： George L. Moore , Ross C. Terrell
发明人： George L. Moore , Ross C. Terrell
IPC分类号： C07D317/42 , C07D317/10
CPC分类号： C07D317/42
摘要： Cyclic ether compounds of the formula ##STR1## wherein n is zero or one, and each X is F when n is zero and is H when n is one, are useful as inhalation anesthetics.
摘要翻译： 式为“IMAGE”的环醚化合物，其中n为0或1，当n为0时，X为F，当n为1时为H，可用作吸入麻醉剂。
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公开(公告)号：US08393321B2
公开(公告)日：2013-03-12
申请号：US10272794
申请日：2002-10-17
IPC分类号： A61M16/00
CPC分类号： A61M16/01 , A61K31/06 , A61M16/009 , A61M16/101 , A61M16/1015 , A61M16/109 , A61M16/18 , A61M2016/0027 , A61M2016/0039 , A61M2016/1035 , A61M2202/0208 , A61M2230/04 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432
摘要： Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties. The instant invention focuses on the dosage level where analgesia occurs but amnesia or lack of consciousness does not. In addition to identifying the dosage level where pain is sharply reduced or eliminated but awareness remains, a delivery system for safe and effective delivery of the agent is described.
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公开(公告)号：US08058482B2
公开(公告)日：2011-11-15
申请号：US11281293
申请日：2005-11-17
IPC分类号： C07C43/13
CPC分类号： C07C41/22 , C07C43/123
摘要： A method for the preparation of (CF3)2CHOCH2F (Sevoflurane) is presented, which comprises providing a mixture of (CF3)2CHOCH2Cl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF3)2CHOCH2F.
摘要翻译： 提供了制备（CF 3）2 CHOCH 2 F（七氟烷）的方法，其包括提供（CF 3）2 CHOCH 2 Cl，氟化钾，水和相转移催化剂的混合物，并使混合物反应形成（CF 3）2 CHOCH 2 F。
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公开(公告)号：US4762856A
公开(公告)日：1988-08-09
申请号：US10106
申请日：1987-02-02
申请人： Ross C. Terrell
发明人： Ross C. Terrell
IPC分类号： A61K31/075 , A61K31/08 , A61P23/00 , C07C43/12
CPC分类号： A61K31/08
摘要： The present invention is directed to an anestesia inducing composition comprising a mixture of oxygen gas and an anesthesia inducing effective amount of a compound 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane having the formula ##STR1## The present invention is also directed to methods of inducing and/or maintaining anesthesia by administering the composition in sufficient amounts to warm blooded animals.
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公开(公告)号：US4365097A
公开(公告)日：1982-12-21
申请号：US244384
申请日：1981-03-16
申请人： Ross C. Terrell , Kirsten Hansen
发明人： Ross C. Terrell , Kirsten Hansen
摘要： Processes for the preparation of certain halogenated aliphatic ethers are described, and in particular the preparation of 1,1,2-trifluoro-2-chloroethyl methyl ether, i.e., CH.sub.3 OCF.sub.2 CHFCl. This particular ether has many uses, and is a valuable material for use in the production of the inhalant anesthetic enflurane, 1,1,2-trifluoro-2-chloroethyl difluoromethyl ether, i.e., CF.sub.2 HOCF.sub.2 CHFCl, made and sold under the trademark ETHRANE by Airco, Inc., Montvale, New Jersey 07645.
摘要翻译： 描述了制备某些卤代脂族醚的方法，特别是制备1,1,2-三氟-2-氯乙基甲基醚，即CH 3 OCF 2 CHFCl。 这种特殊的醚具有许多用途，并且是用于生产吸入性麻醉剂安氟氟烷，1,1,2-三氟-2-氯乙基二氟甲基醚，即CF 2 HOCF 2 CHFCl的有价值的材料，即由Airco以商标ETHRANE制造和销售的CF 2 HOCF 2 CHFCl ，Inc.，Montvale，New Jersey 07645。
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